DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14221 and PDIA5

DIOPT Version :9

Sequence 1:	NP_001259713.1	Gene:	CG14221 / 32961	FlyBaseID:	FBgn0031042	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_006801.1	Gene:	PDIA5 / 10954	HGNCID:	24811	Length:	519	Species:	Homo sapiens

Alignment Length:	148	Identity:	30/148 - (20%)
Similarity:	56/148 - (37%)	Gaps:	37/148 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GGVQQLQADLASDEEFEKFLQRSGLLVLDIYSEWCGPCLGMVGSLRKIKLELGGD---------- 59
            |.|..|     :||:|::|::....:::..::.|||.|..|.....|....|.|:
Human   276 GSVYHL-----TDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAV 335

  Fly    60 ----NLQLA----ICKAGSISYLKRFNKKSEPTWMFVTSGKAINIMFGTDVP------------K 104
                |..||    |.:..::.|.|...|.:.|  :..|..|.:..|...:.|            .
Human   336 DATVNKALAERFHISEFPTLKYFKNGEKYAVP--VLRTKKKFLEWMQNPEAPPPPEPTWEEQQTS 398

  Fly   105 LVAMITRMLQSTMAKETH 122
            ::.::....:.|:.|:.|
Human   399 VLHLVGDNFRETLKKKKH 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14221	NP_001259713.1	Thioredoxin_like	11..111	CDD:294274	24/129 (19%)
CG14221	NP_001259713.1	DUF4746	233..508	CDD:292550
PDIA5	NP_006801.1	PDI_b_PDIR_N	28..139	CDD:239365
		PDI_a_PDIR	152..256	CDD:239295
		PTZ00102	168..512	CDD:240266	30/148 (20%)
		PDI_a_PDIR	277..379	CDD:239295	24/108 (22%)
		PDI_a_PDIR	398..501	CDD:239295	3/19 (16%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	516..519
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910