DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14205 and CG12990

DIOPT Version :9

Sequence 1:	NP_608323.1	Gene:	CG14205 / 32952	FlyBaseID:	FBgn0031034	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_573233.1	Gene:	CG12990 / 32747	FlyBaseID:	FBgn0030859	Length:	663	Species:	Drosophila melanogaster

Alignment Length:	767	Identity:	162/767 - (21%)
Similarity:	294/767 - (38%)	Gaps:	192/767 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLVMSLALTSASIRVEHPKNSTLNVGNPEWQSQSYHTISRLRRLAVEFFAQYQNITISDLYRDKE 76
            |||:.|....|::.         :|.|.|.:|        |.:..:|...|.:|.|:|
  Fly     2 LLVLLLLQIIAALG---------DVDNCEPKS--------LAKDLIEMVPQRENTTLS------- 42

  Fly    77 IRLPTTDDLRCLADLQTLAKDVSDRKLWALRMIDSWGTFPSGILYGNVIDLGNFDECLGIDHAVT 141
                     :|...|..|.:...|.:.|||:.||:.|...:..:.|....|||...|..::..:.
  Fly    43 ---------KCEEQLLELRRAWQDHQSWALKAIDASGEGYANFMMGQRAWLGNRFTCRAVNEPML 98

  Fly   142 STHNVQGKYCLSKL------------------QLASSIPTFLALKTAVCFPASCSADHMDTMLRR 188
            ....::.:..|.::                  ||..:|.....|...:|.||||....::.::|:
  Fly    99 QDMTIKNQRLLREMSPIQFHYLVAYIESNSPWQLEVTIKANPLLHIGLCLPASCDVPEVEQLIRK 163

  Fly   189 LLQNLLSI---ELNPDVPLVSEGTCKTADREPYD--ALTIFTIVVLSILCVLMVLATVCDYLVCQ 248
            .:....|.   :::..:....:...||   ..:|  |:.|| .|||.:..:|.:.||
  Fly   164 SMAKEESFHCWDMDAKLAYAKKPELKT---NFFDSGAVQIF-FVVLGVTLLLTLAAT-------- 216

  Fly   249 DDQPLNKW---IKAFSARANCRILFRLVAPRSNPNVIDCLHGIRVLSFIWVVYGHIYLVSFFG-- 308
              ..|.|:   :..|....|.|:.::.|.|......:   :|:|||:...::..|:....:|.
  Fly   217 --SGLGKYSRILACFDFADNWRLAWKPVNPSQENRPV---NGLRVLTAFSLIGVHVIWYKYFSVD 276

  Fly   309 PNMNLV-KLDTWRRSPYSMLVQHAAY--SVDTFFFLSGLLMVVIALRAMERTKGKLNVSLM---- 366
            |::.:: ||.       ||.::|..:  .|:.||.:||.|.|:..:|..:..|...:..::
  Fly   277 PSVEMLGKLS-------SMTMRHTYWPTMVEIFFVVSGYLTVLNFIRDEQLQKDIASDGILGNMR 334

  Fly   367 -----YLHRYLRLTP------VLALAIIVYMSILPRMGDGPLYGKVNFDDYSKCKDTWYWTLLYV 420
                 ::|||.||.|      ::.:.:|.|...:..|       ::.......|:......:.::
  Fly   335 RYLREFIHRYCRLAPLQFVIVLMGVVVIEYQRQVSVM-------QITDPQDELCRLNAVRNVFFI 392

  Fly   421 QN-YATDEICLGHSWYLAVDMQLYIIAPILLIC------LYKWGKKAAAGILVAMLLLAACLFSI 478
            || :....:|...:|.|..||||::.|.:||..      :.||        :|.:|::.:.||||
  Fly   393 QNLFPIQFMCGSWTWSLGCDMQLHMTAMLLLFMHTKHPNMVKW--------IVRLLVVISALFSI 449

  Fly   479 MVIGDVSLIAISEGAM----EKIYFSTHTRASPYLIGILFGYFLHVNRGKSFKLSPITVVLGWLT 539
             |..:|:.:..:...|    |..|.|...|...|:||..:.:|.....|..|.|    |:..|..
  Fly   450 -VFMEVNEVGANFEEMYHTNEWSYMSPLIRMLAYIIGGSYAFFQVKGTGTPFDL----VMPNWWI 509

  Fly   540 SLALLFSCLFAVYGYAADAEIPPIVEEAFYLTFTRI-----AWPLGLC--------------WVV 585
            .|..: :|:..:.......::|.|.....::...||     |..|.:|              |::
  Fly   510 RLGAI-ACIGWLARQVTMDQLPAISIILSFMVVLRILVSTAASHLIICGTKPDNSDSYAPTRWLL 573

  Fly   586 FACMHGYGGLANSFLSSPLWQPLSKLSYS---------AYIFHMFMESLNAGITRTNTYFSD--Y 639
                        :.|.|...|.:||.:|:         .|::|.|          :|..:.|  .
  Fly   574 ------------ALLQSEQVQRISKFTYAIYLLNPIVIMYVYHSF----------SNEVYPDNTM 616

  Fly   640 QVMLRFWCDFGFTVLLAFAVYILIEAPFGNLEGLLLPDKRPCPPRPAVEESK 691
            .:||...|.. ...|.|..:.:|.|.||..|..:::..:    ..||.::|:
  Fly   617 MIMLAISCSV-VCYLWAIVMTVLFEIPFNRLTSVMINSR----SSPAKKKSQ 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14205	NP_608323.1	NRF	102..212	CDD:214781	23/130 (18%)
		OafA	269..667	CDD:224748	97/458 (21%)
		Acyl_transf_3	282..660	CDD:280013	93/438 (21%)
CG12990	NP_573233.1	NRF	61..162	CDD:214781	21/100 (21%)
		Acyl_transf_3	251..637	CDD:280013	93/439 (21%)
		OafA	295..660	CDD:224748	88/412 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453351
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3700
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850