DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14205 and CG3106

DIOPT Version :9

Sequence 1:	NP_608323.1	Gene:	CG14205 / 32952	FlyBaseID:	FBgn0031034	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	NP_001285060.1	Gene:	CG3106 / 31909	FlyBaseID:	FBgn0030148	Length:	742	Species:	Drosophila melanogaster

Alignment Length:	763	Identity:	262/763 - (34%)
Similarity:	410/763 - (53%)	Gaps:	81/763 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVKHSTGPIVSLLVMSLALTSASIRVEHPKNSTLNVGNPEWQSQSY-HTISRLRRLAVEFFAQYQ 64
            |::|.....|.||:      :.::..:...::.|..|:....:.|: |....|...:.| .|...
  Fly     1 MMEHFGVLAVVLLI------ATAVGAQDTSSNYLLTGHSTPLASSFAHQFFTLASQSAE-LANRT 58

  Fly    65 NITISDLYRDKEIRLPTTDDLRCLADLQTLAKDVSDRKLWALRMIDSWGTFPSGILYGNVIDLGN 129
            |..:...|.|:..     ||..|..|:..:...:::.:.|||...|:||..|.|:.:|:.|.:|.
  Fly    59 NTQVIQTYEDRNY-----DDELCDRDINLIRDSINNLEEWALEFPDTWGRLPMGLFWGHTISMGQ 118

  Fly   130 FDECLGIDHAVTSTH--NVQGKYCLSKLQLASSIPTFL---------------------ALKTAV 171
            ::||:    |.:|||  .::|:|||:.|    :|.||.                     ..:..:
  Fly   119 YEECV----AASSTHTTEIRGQYCLASL----NITTFYQSVKKRGEEFSRISYKQTDPEVFELGI 175

  Fly   172 CFPASCSADHMDTMLRRLLQNLLSIE-LNPDVPLVSEGTCKTADREPYDA------LTIFTIVVL 229
            |.|.:|||...:.:|:..:.:....: :..:..:|:|..||      |||      :.||.|:..
  Fly   176 CVPKTCSAAKTEKLLKYAITHFYGQDVMESNYTMVTEARCK------YDAPIELRGIDIFAIIFF 234

  Fly   230 SILCVLMVLATVCDYLVCQDDQPLNKWIKAFSARANCRILFRLVAPRSNPNVIDCLHGIRVLSFI 294
            |::...||.::|.||:..:...|....:.|||...|...:| .|...:|||||.||:|:|..|.:
  Fly   235 SLIIFFMVASSVYDYIQTRKGAPKKPLLIAFSVLTNAPKIF-TVKKVNNPNVIHCLNGLRCFSMM 298

  Fly   295 WVVYGHIYLVSFFGPNMNLVKLDTWRRSPYSMLVQHAAYSVDTFFFLSGLLMVVIALRAMERTKG 359
            |||:||.|:..:..|::|..|..||.::|||||||:.:..||||||:|||||...|.|.||||||
  Fly   299 WVVFGHGYMTFYDLPHINKNKFYTWVQTPYSMLVQNGSLCVDTFFFMSGLLMCWGAFREMERTKG 363

  Fly   360 KLNVSLMYLHRYLRLTPVLALAIIVYMSILPRMGDGPLYGKVNFDDYSKCKDTWYWTLLYVQNYA 424
            |||:.:||.|||:|||||:|:.::..||:....|.||::.|:...| .:|.|||:.||:||||||
  Fly   364 KLNIPMMYFHRYIRLTPVVAVVVLYIMSLYKYSGAGPMWFKLGTQD-KRCADTWWATLIYVQNYA 427

  Fly   425 TD-EICLGHSWYLAVDMQLYIIAPILLICLYKWGKKAAAGILVAMLLLAACLFSIMVIGDVSLIA 488
            .. .||:..|||||||.|||.::|:.||.|:||||||...|::.::|.....|:..::.|.:|..
  Fly   428 FPYSICISQSWYLAVDTQLYFLSPLFLIPLWKWGKKALVPIVIVLILCLGGTFATFMLNDFTLFR 492

  Fly   489 ISEGAME----KIYFSTHTRASPYLIGILFGYFLHV-NRGKSFKLSPITVVLGWLTSLALLFSCL 548
            :.:..::    ..|:.||||...:|||::|||||.. |||:...:|...|:.||..:...:.:|:
  Fly   493 VQDDQVDLRQRLTYYPTHTRIPTWLIGVIFGYFLFTRNRGRQIPMSKPLVLTGWFVAFGTMLACM 557

  Fly   549 FAVY-GYAADAEIPPIVEEAFYLTFTRIAWPLGLCWVVFACMHGYGGLANSFLSSPLWQPLSKLS 612
            :..| ....|....|::|.||:...:|.:|.|.:.|:|:||.:|:|||.|.|||...:...|:|.
  Fly   558 WGPYWRILPDTPDSPLIEGAFFEPLSRTSWALSIGWIVWACYNGHGGLVNDFLSWGFFTGFSRLC 622

  Fly   613 YSAYIFHMFMESLNAGITRTNTYFSDYQVMLRFWCDFGFTVLLAFAVYILIEAPFGNLEGLLLPD 677
            |..|:.|..::.:||...:|:|:||:|..:||:|.|||.|:..:....:..|||...:|..:.
  Fly   623 YCMYVIHRIVQLVNAARLQTDTHFSNYDAILRWWHDFGITLTASIFATLAFEAPILGIEKAIF-- 685

  Fly   678 KRPCPPRPAVEE-SKEAPVGGCSASA---------PTLENKT---PLP 712
            .:|.|.:|:..| :|.|||...||||         ..:|.||   |:|
  Fly   686 GKPAPKKPSPGELAKAAPVAATSASAEPEPEAKPESVVETKTEIAPVP 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14205	NP_608323.1	NRF	102..212	CDD:214781	34/133 (26%)
		OafA	269..667	CDD:224748	172/404 (43%)
		Acyl_transf_3	282..660	CDD:280013	164/384 (43%)
CG3106	NP_001285060.1	NRF	91..217	CDD:214781	35/139 (25%)
		Acyl_transf_3	286..635	CDD:280013	150/349 (43%)
		OafA	289..702	CDD:224748	171/415 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458085
Domainoid	1	1.000	50	1.000	Domainoid score	I11639
eggNOG	1	0.900	-	-		E1_KOG3700
Homologene	1	1.000	-	-		H129774
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4016
Isobase	1	0.950	-	0	Normalized mean entropy	S7984
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm25504
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
	13	12.750