DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14205 and oacyl

DIOPT Version :9

Sequence 1:	NP_608323.1	Gene:	CG14205 / 32952	FlyBaseID:	FBgn0031034	Length:	713	Species:	Drosophila melanogaster
Sequence 2:	XP_021324686.1	Gene:	oacyl / 100002566	ZFINID:	ZDB-GENE-090710-2	Length:	676	Species:	Danio rerio

Alignment Length:	693	Identity:	172/693 - (24%)
Similarity:	278/693 - (40%)	Gaps:	159/693 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LRCLAD----LQTLAKDVSDRKLWALRMIDSWGTFPSGILYGNVIDLGNFDECLGIDHAVTSTHN 145
            |:|:.|    |..|.|:...:  :|:.|.|::|...|.:..|||...|:..|||.::..     .
Zfish    27 LKCVDDTMGFLMELQKETPSK--FAVIMYDAFGKIGSDVEGGNVNRPGSLRECLSVEGP-----G 84

  Fly   146 VQGKYCLSKLQLASSIPTFLALKTAVCFPASCSADHMDTMLRRLLQNLLSIELNPDVP--LVSEG 208
            .:|:||...|: ...:..|:    .||.|.||:...:.|::.........:.|.|.||  |:.:.
Zfish    85 FRGQYCQVFLK-QDKVEYFV----GVCVPDSCTDSEVQTLVIHEAFQKQQMSLLPSVPSILIPDS 144

  Fly   209 TC---KTADREPYDALTIFTIVVLSILCVLMVLATVCDYLV------------------------ 246
            |.   .|........:.:..||.||:.|.|:.|..:....|
Zfish   145 TLGIFMTQCHSDSPNIDLSAIVCLSVCCALLALPLIASIFVALIKRKQMREVAPVVGLAQTSNSK 209

  Fly   247 ----------------CQDD---------------QPLNK----WIKAFSARANCRILFRLVAPR 276
                            |..|               |.|:|    |::.||.: ||.  ..|:...
Zfish   210 QYGTVLTNGSANQNKECSPDLDTTQTKTQNAESKQQSLSKTVVSWLQGFSVQ-NCS--QGLLDTE 271

  Fly   277 SNPNVIDCLHGIRVLSFIWVVYGH------------------------IYLVSFFGPNMNLVKLD 317
            .:......|:|||:||..|::.||                        :|:::|.||
Zfish   272 GSGRSYSSLNGIRILSLFWIISGHTVHFSAWSHLDNEKRWKEMVENNPLYVLTFSGP-------- 328

  Fly   318 TWRRSPYSMLVQHAAYSVDTFFFLSGLLMVVIALRAMERTKGKLNVSLM--YL-HRYLRLTPV-- 377
                         ...:||:|..|.|||.....|..:.|:...|:|.|:  || .|:.|:.|:
Zfish   329 -------------VYLAVDSFLVLGGLLSAKSLLGTIRRSDNTLSVGLVVNYLFKRFKRIQPLHL 380

  Fly   378 -LALAIIVYMSILPRMGDGPLYGKVNF---DDYSKCKDTWYWTLLYVQNYAT-DEICLGHSWYLA 437
             :...:|...|::||       |...|   |....||..|:..||.:.|..| .:||...:|||:
Zfish   381 FIVCLVISLFSVVPR-------GVFWFFAEDQVLSCKKYWWSNLLLINNLLTITDICAPWTWYLS 438

  Fly   438 VDMQLYIIAPILLICLYKWGKKAAAGILVAMLLLAACL------FSIMVIGDVSLIAISEGAMEK 496
            :|.|.|...| |||.||:..|.|...:.|.:|:|::..      |..:.:...:.:|. |...:.
Zfish   439 IDFQFYATTP-LLIFLYRMNKCALVVVSVVLLMLSSVTGALITSFLHLPVHQPTTLAY-ESYFQY 501

  Fly   497 IYFSTHTRASPYLIGILFGYFLHVNRGKSFKLSPITVVLGWLTSLALLFSCLFAVYGYAADAEIP 561
            .|...:||..|||:|:|.|.::...:....| .....|:|||.||:::  .|.....|.. .::|
Zfish   502 YYNKPYTRYGPYLLGVLAGIYMTTKKEALIK-HQWQAVIGWLCSLSVM--ALLVGLAYVL-RDVP 562

  Fly   562 P--IVEEAFYLTFTRIAWPLGLCWVVFACMHGYGGLANSFLSSPLWQPLSKLSYSAYIFHMFMES 624
            |  .:..|.|....|..|.|.|.|::.||..||||..::|||..||.|||.:|::.|:.|..:..
Zfish   563 PHLSIPHAIYQGIHRSLWALALIWIILACEEGYGGFVDTFLSLSLWAPLSNISFACYLIHPIIII 627

  Fly   625 LNAGITRTNTYFSDYQVMLRFWCDFGFTVLLAFAVYILIEAPF 667
            |..|......:::|:.....|......::.:.:.:.:|||..:
Zfish   628 LYNGKQEITMHYTDFNFFYLFLGHLVLSIFIGYVLTVLIEKTY 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14205	NP_608323.1	NRF	102..212	CDD:214781	29/114 (25%)
		OafA	269..667	CDD:224748	118/439 (27%)
		Acyl_transf_3	282..660	CDD:280013	114/419 (27%)
oacyl	XP_021324686.1	NRF	48..120	CDD:214781	23/81 (28%)
oacyl	XP_021324686.1	OafA	273..668	CDD:224748	116/428 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588174
Domainoid	1	1.000	50	1.000	Domainoid score	I11639
eggNOG	1	0.900	-	-		E1_KOG3700
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H129774
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4016
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm25504
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4398
SonicParanoid	1	1.000	-	-		X299
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.690