DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14204 and CG16723

DIOPT Version :9

Sequence 1:	NP_001259710.1	Gene:	CG14204 / 32950	FlyBaseID:	FBgn0031032	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_651159.3	Gene:	CG16723 / 42781	FlyBaseID:	FBgn0039092	Length:	695	Species:	Drosophila melanogaster

Alignment Length:	720	Identity:	344/720 - (47%)
Similarity:	472/720 - (65%)	Gaps:	46/720 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIKLLAILLAMGMAMVQGALPTQLSNNQWTQHDVSSMADYERLLDLRSLAMEFYREFRNISTADV 65
            |:.::.:||..|: :...||       :.|..|||.  .||.:..||.|.:||...|:|::...:
  Fly     1 MVNVVGVLLFYGL-VATCAL-------ELTDPDVSK--TYEYISQLRPLGLEFAEFFKNVTLESL 55

  Fly    66 HLLGERIGS-QDLQCLADMAQFMSALSAPKAWALKMLDAWGTIPSGYLIGNRVDMGNYRECLS-- 127
            .:...::.| :|..|..::|..|:.:|..:.|||||:||||:||:|.|.||..|:||:.||||
  Fly    56 GVSDSKLASAEDELCSVELAAVMNGISLRETWALKMIDAWGSIPNGLLTGNLFDLGNFDECLSIE 120

  Fly   128 --EGGMLTSSQDIQGKYCFMELPVAKWLGFTSELLAVTNIRTAVCLPSSCSAGTMELFLKQLLKR 190
              .||     :.|:||:||               |...:.|.|.|.|:|||:..||.|::||: .
  Fly   121 KVVGG-----KRIRGKFCF---------------LLANSARIATCFPASCSSTQMETFVEQLM-A 164

  Fly   191 LLGVSDPTNLFSISETSCRIKEKAPWDGLTIFTVVLLSVFGVTVILCTLYDYFLCPEQEKLPRPI 255
            |:.::..:....||..||:..|..||:||||||:|:||:..|.||..|::|||||.:...:|..:
  Fly   165 LINLNSSSLKMRISGASCQTSEIEPWNGLTIFTIVILSLMCVIVISVTIFDYFLCDDPRSIPAVV 229

  Fly   256 GAFSARATSRSLFTIVENTANPNVIHCLNGMRCMSLIWVILSHEYIINMKGPAINPADNLRWATQ 320
            ..|||||.||:||.||.|.:|||||.|.:|:|||:|.|||..||:|..:..|.:|..|...|..:
  Fly   230 KTFSARANSRALFRIVPNKSNPNVIECFHGIRCMTLFWVIYCHEFIFFLTSPNLNRLDLYTWTVK 294

  Fly   321 LFSSFILYGTLSVDTFFFISGLLLVSIGLRSIEKNKGKLNVPLMYLHRYLRLTPIVAVAILAFYK 385
            .||||:|:|..:||:||.:.|||:..|.|||:||:.|:||..||||||.||:.|:||:|||.:..
  Fly   295 PFSSFVLHGYFAVDSFFVLGGLLVSMISLRSMEKSGGRLNPVLMYLHRILRILPVVAIAILIYMT 359

  Fly   386 MIPLIADGPMYDDIGFFDYSGCKMTWYWTLLYVQNYATSDVCVPHTWYLAVDMQLYILSPILLIA 450
            |:.:::.|||..: |:.....|...|:||||::||||..::|:.|||||||||||:|:|||||:|
  Fly   360 MMTVVSGGPMLKN-GYHGMEYCLNGWFWTLLFIQNYAVQNICLDHTWYLAVDMQLFIISPILLMA 423

  Fly   451 LYKWGKKAAGGILVVTLLLSACLFATIMVNDFPVMFK-NGIQAQVVQRKIYTATHTHAAPWLVGT 514
            ||.||||||.||.|:.:|||.|||||.|||.:.::.| |.....|..:|:|.||||||||||:|.
  Fly   424 LYNWGKKAASGIAVLVVLLSGCLFATQMVNHYTLLIKINDGDDGVPNKKLYLATHTHAAPWLIGF 488

  Fly   515 MFGYLLHLMRGRRFKLSLLATWAGWLLCLAPLFTSIFALYPYSKLLGKSPSVLQGALYYTLVRIA 579
            :|||.||:.||::|:||....|.||:|.||.||||||||||.|:|.....|.|:.:|||||.|:|
  Fly   489 LFGYFLHINRGKKFQLSRPIVWLGWILSLAMLFTSIFALYPASQLTAPPLSTLEESLYYTLTRLA 553

  Fly   580 WPLGLCWVVFACMQGYGSLANSFLSSPLWQPLSKLSYGAYIWHIFVVEVANRSVQTNTYFSNYQV 644
            |||.:||::||||||||.|||||||:|||||||:|||..||||:||.||.:|:|:|||||:||..
  Fly   554 WPLAICWIIFACMQGYGGLANSFLSTPLWQPLSRLSYSMYIWHMFVQEVNSRNVRTNTYFTNYIA 618

  Fly   645 MLNFWSTFGFTLLMSYVLYVLIEAPLEALERIMFPNRRSPPAAKDQLHIESRTEVVDQMDQMDHM 709
            |..|....|||:||||:||::|||||...:.|: ..|:.|||       .::..::.....|::.
  Fly   619 MERFCYDLGFTVLMSYILYLIIEAPLCGFDSIL-RGRKDPPA-------PNKANIISNERGMENR 675

  Fly   710 DGMDQ 714
            |..||
  Fly   676 DPEDQ 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14204	NP_001259710.1	NRF	94..209	CDD:214781	46/118 (39%)
		Acyl_transf_3	280..664	CDD:280013	219/384 (57%)
		OafA	283..687	CDD:224748	227/404 (56%)
CG16723	NP_651159.3	NRF	87..184	CDD:214781	47/117 (40%)
		Acyl_transf_3	254..599	CDD:280013	196/345 (57%)
		OafA	291..644	CDD:224748	207/353 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458056
Domainoid	1	1.000	50	1.000	Domainoid score	I11639
eggNOG	1	0.900	-	-		E1_KOG3700
Homologene	1	1.000	-	-		H129774
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4016
Isobase	1	0.950	-	0	Normalized mean entropy	S7984
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm25504
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
	13	12.750