DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14204 and CG5892

DIOPT Version :9

Sequence 1:	NP_001259710.1	Gene:	CG14204 / 32950	FlyBaseID:	FBgn0031032	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_650959.2	Gene:	CG5892 / 42522	FlyBaseID:	FBgn0038873	Length:	738	Species:	Drosophila melanogaster

Alignment Length:	705	Identity:	346/705 - (49%)
Similarity:	463/705 - (65%)	Gaps:	9/705 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIKLLAILLAMGMAMVQGALPTQLSNNQWTQHDVSSMADYERLLDLRSLAMEFYREFRNISTADV 65
            |.|:..::|.:|:| |..||......|:..:.|..   ||:||..:|.|:.:|:..::|::..|:
  Fly     1 MAKVSVVVLILGLA-VTSALDFGPEINEGNELDAQ---DYQRLNKVRHLSEQFFSYYKNVTLDDL 61

  Fly    66 HLLGERIGSQDLQCLADMAQFMSALSAPKAWALKMLDAWGTIPSGYLIGNRVDMGNYRECLSEGG 130
            ...|......||||.||.||..:.|::...||.:|:|:||:||||.|.|:..|:|:|.||::...
  Fly    62 VPEGRLPTVSDLQCYADFAQLTAGLASGSLWAYRMIDSWGSIPSGILKGHLKDLGHYDECIAIEQ 126

  Fly   131 MLTSSQDIQGKYCFMELPVAKWLGFTSELLAVTNIRTAVCLPSSCSAGTMELFLKQLLKRLLGVS 195
            ...|...:.||||...||:.:.||....::   |::||||.|:||||..|:..|:::||:|:|:.
  Fly   127 SAASGSTLLGKYCLASLPLQQLLGNVGRMM---NVQTAVCFPASCSATNMDTLLRRVLKQLVGLE 188

  Fly   196 DPTNLFSISETSCRIKEKAPWDGLTIFTVVLLSVFGVTVILCTLYDYFLCPEQEKLPRPIGAFSA 260
            ..:|...:||.||:..|:..:||..|..:|:|||||..||:.|.||||||.:|.|||..:..|||
  Fly   189 LNSNQNLVSENSCKTSERDAYDGGAIAAIVILSVFGGAVIISTFYDYFLCADQNKLPAILKVFSA 253

  Fly   261 RATSRSLFTIVENTANPNVIHCLNGMRCMSLIWVILSHEYIINMKGPAINPADNLRWATQLFSSF 325
            ||.|||||.|. ...|||||.||:|:|.||||||...|::||:|..|.||..|...||...|...
  Fly   254 RANSRSLFRIT-TKPNPNVIECLHGLRGMSLIWVCFGHDFIISMTSPNINLYDVYTWAKTPFKDI 317

  Fly   326 ILYGTLSVDTFFFISGLLLVSIGLRSIEKNKGKLNVPLMYLHRYLRLTPIVAVAILAFYKMIPLI 390
            |..|..:||:||||||||:..:.|||:||.|||||:|||||||||||||||||:||.::|::|.:
  Fly   318 IQEGVFAVDSFFFISGLLVAMVALRSMEKAKGKLNIPLMYLHRYLRLTPIVAVSILLYWKLLPHL 382

  Fly   391 ADGPMYDDIGFFDYSGCKMTWYWTLLYVQNYATSDVCVPHTWYLAVDMQLYILSPILLIALYKWG 455
            .|||:|.:..|..|..|:..|||||||||||||...|:.||||||:|.||||::|||||.:||||
  Fly   383 GDGPLYGNWNFDSYDRCEGNWYWTLLYVQNYATDSECLAHTWYLAIDTQLYIIAPILLIIVYKWG 447

  Fly   456 KKAAGGILVVTLLLSACLFATIMVNDFPVMFKNGIQA-QVVQRKIYTATHTHAAPWLVGTMFGYL 519
            ||.|..:|::.|.|:|.||:.|::|::.::...|... ......:...||..|:.||||.:|||.
  Fly   448 KKGAAVVLLLLLGLTAYLFSIIVINNYSLISGGGGGGPDDYSEDLDHYTHNRASGWLVGFLFGYF 512

  Fly   520 LHLMRGRRFKLSLLATWAGWLLCLAPLFTSIFALYPYSKLLGKSPSVLQGALYYTLVRIAWPLGL 584
            ||.:||:..|||..|.|.||:.|||.|||.|||:|||.....|:...|..|.|.:|.||||||||
  Fly   513 LHTIRGKAIKLSRPAVWIGWITCLAFLFTCIFAMYPYGTGKSKTLPTLNEAFYVSLSRIAWPLGL 577

  Fly   585 CWVVFACMQGYGSLANSFLSSPLWQPLSKLSYGAYIWHIFVVEVANRSVQTNTYFSNYQVMLNFW 649
            .|||||||||||.||||||:|||||||||||:.||:.|:|:..:.....:.|||||||.:||.||
  Fly   578 SWVVFACMQGYGGLANSFLTSPLWQPLSKLSFCAYMGHLFIQNLNAGRTRVNTYFSNYDIMLRFW 642

  Fly   650 STFGFTLLMSYVLYVLIEAPLEALERIMFPNRRSPPAAKDQLHIESRTEVVDQMD 704
            ..||||:|::||:|:|||||...||.::.||||..|..|.|....|:.|:...:|
  Fly   643 QDFGFTVLLAYVMYILIEAPCGGLESLILPNRRPAPQPKVQAAEPSKEEIPSPVD 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14204	NP_001259710.1	NRF	94..209	CDD:214781	46/114 (40%)
		Acyl_transf_3	280..664	CDD:280013	214/384 (56%)
		OafA	283..687	CDD:224748	225/404 (56%)
CG5892	NP_650959.2	NRF	90..203	CDD:214781	47/115 (41%)
		Acyl_transf_3	272..656	CDD:280013	214/383 (56%)
		OafA	277..685	CDD:224748	226/407 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458036
Domainoid	1	1.000	50	1.000	Domainoid score	I11639
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H129774
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4016
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm25504
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
	11	10.900