DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14204 and CG11353

DIOPT Version :9

Sequence 1:	NP_001259710.1	Gene:	CG14204 / 32950	FlyBaseID:	FBgn0031032	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_647915.1	Gene:	CG11353 / 38560	FlyBaseID:	FBgn0035557	Length:	754	Species:	Drosophila melanogaster

Alignment Length:	780	Identity:	182/780 - (23%)
Similarity:	312/780 - (40%)	Gaps:	150/780 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLAILLAMGMAMVQGALPTQLSNNQ--WTQHDVS------SMADYERLLDLRSLAMEFYREFRNI 60
            |:.:.|.:|..:.:||.....:.|.  |.::...      ::.|...:||..| .:|.:
  Fly    17 LMLLGLWLGSVLAKGASNQSATTNSHAWQRYHSQALNASPALPDELEILDAPS-TIEIH------ 74

  Fly    61 STADVHLLGERI----------GSQDLQCLADMAQFMSALSAPKAWALKMLDAWGTIPSGYLIGN 115
            |..:.||....:          .|...:|.|.:.|....:...:.||:|:|||.||.|||::.|.
  Fly    75 SPHETHLTRTSVIFGLTKVANESSVSQKCHAQLRQMQRGILGKQPWAMKVLDASGTKPSGFVYGQ 139

  Fly   116 RVDMGNYREC----------LSEG-------GMLTSSQDIQGKYCFMELPVAKWLGFTSELLAVT 163
            ...:|:...|          ||:.       |::|........|..:.|..........:|::..
  Fly   140 NYWLGSREACRGVQRPVGITLSKNFDRVMHYGIITQQAPFDMDYRVLYLRHNSPWQVEIKLMSEQ 204

  Fly   164 NIRTAVCLPSSCSAGTMELFLKQLLKRLLGVSDPTNLFSISETSCRIK---------EKAPWDGL 219
            .|...:||||:||:..::...:..:..  |:.....:|.|......:|         |:|.:  .
  Fly   205 IIHIGLCLPSACSSVEVQSLAQDYVAG--GMFTENEIFDIKPEVVYMKDLQLKDEFFERASF--R 265

  Fly   220 TIFTVVLLSVFGVTVILCTL---------------YDYFLCPEQ-------------EKLPRPIG 256
            .:...|||:   ||::.|..               .|..|.|.:             |:|.|.:.
  Fly   266 LLVACVLLT---VTLMFCAQQLHATSKMPSISVDPLDRDLAPAESEIWRGLNSLLQIERLQRYVT 327

  Fly   257 AFSARATSRSLFTIVENTANPNVIHCLNGMRCMSLIWVILSH-----EYIINMKGPAINPADNLR 316
            .:........:|.|.|||||.  |..:||:|.:..||:::.|     .:.::.|...|:
  Fly   328 CWDVPGNWAKIFAIRENTANE--IPLMNGLRSVCAIWIMVFHVVWFMYFTVHNKTVLIS------ 384

  Fly   317 WATQLFSSFILYGTLSVDTFFFISGLLLV------SIGLRSIEKNKGKLNVPL---MYLHRYLRL 372
            :|.|.|..::....|.||.||.|||.|..      |..|.::.:|....|:.|   :..||||||
  Fly   385 YAEQAFFQYVSSAPLLVDVFFTISGFLQTFNFLRNSRQLEAVRQNSFSENLKLFGKLLFHRYLRL 449

  Fly   373 TPIVAVAILAFYKMIPLIADGPMYDDIGFFDYSGCKMTWYWTLLYVQN-YATSDVCVPHTWYLAV 436
            .|:..|.:.....:...|.|..:|.....|| ..|...|:..||::|| :...|:|...:|.||.
  Fly   450 GPLYLVVMATVDLVYAYIGDVSVYHINERFD-EMCTRHWWRNLLFIQNLFDHRDMCANWSWSLAC 513

  Fly   437 DMQLYILSPILLIALYKWGKKAAGGILVVTLLLSACLFATIMVN-----------DFPVMFKNGI 490
            :||.:||:..||....|:.|       ||..|:.:...|||..:           .|...|..|.
  Fly   514 EMQFFILANALLFLYVKYPK-------VVKSLVVSSFVATIAWSYGIGLSIKFQLSFDAAFATGT 571

  Fly   491 QAQVVQRKIYTATHTHAAPWLVGTMFGYLLHLMRGRRFKLSLLATWAGWLLCLAPLFTSIFALYP 555
            :       |||:......|:::|.:..:||...| .:.::|.....|.|...|...|..|::  .
  Fly   572 E-------IYTSPFVRVLPYILGAVTAWLLQENR-VQLEISEQKERACWHFALFVFFACIYS--T 626

  Fly   556 YSKLLGKSPSVLQGALYYTLVRIAWPLGLCWVVFACMQGYGSLANSFLSSPLWQPLSKLSYGAYI 620
            ..:.||.    |.....:.:.|:.:.|.:||::.....|.|...:..|.:..:|.:|:|||..|:
  Fly   627 VKRDLGP----LMAITLFVMGRLFFSLSVCWMIARSCDGRGVWWSRLLEAKGFQHVSRLSYAIYL 687

  Fly   621 WHIFVVEVANRSVQTNTYFSNYQVMLNFWSTFGFTLL--MSYVLYVL-IEAPLEALERIMFPNRR 682
            .:..|:.:.......:|:...:.:.:   .|.||.::  ::.:|:.| .|.|...|..::  |||
  Fly   688 LNPLVIALFYSLTNASTHADPFMLCV---VTCGFAVIVYLASILFSLAFELPFSNLSSLL--NRR 747

Fly 683 682
Fly 748 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14204	NP_001259710.1	NRF	94..209	CDD:214781	31/131 (24%)
		Acyl_transf_3	280..664	CDD:280013	103/411 (25%)
		OafA	283..687	CDD:224748	109/429 (25%)
CG11353	NP_647915.1	NRF	118..243	CDD:214781	30/126 (24%)
		OafA	349..752	CDD:224748	110/432 (25%)
		Acyl_transf_3	352..729	CDD:280013	101/407 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453356
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3700
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850