DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14204 and CG14219

DIOPT Version :9

Sequence 1:	NP_001259710.1	Gene:	CG14204 / 32950	FlyBaseID:	FBgn0031032	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_608322.1	Gene:	CG14219 / 32951	FlyBaseID:	FBgn0031033	Length:	724	Species:	Drosophila melanogaster

Alignment Length:	705	Identity:	336/705 - (47%)
Similarity:	475/705 - (67%)	Gaps:	28/705 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LAILLAMGMAMVQGALPTQLSN-------NQWTQHDVSSMADYERLLDLRSLAMEFYREFRNIST 62
            ||.:|.:|:..:..::..|::|       ...|:| ::....|..:.:.|.|::||:..:.|::.
  Fly     4 LAFILGLGLLALAKSVNAQMTNIFAMTNTKLLTEH-IAGGDHYSSIFNTRRLSVEFFEHYANVTL 67

  Fly    63 ADVHL-LGERIGS-QDLQCLADMAQFMSALSAPKAWALKMLDAWGTIPSGYLIGNRVDMGNYREC 125
            .|:.. ...||.| |||:||||:|.....||:.|.|||||:|:||.:|||.|.||..::||:.||
  Fly    68 EDLTANSNSRIPSLQDLECLADLALLSKDLSSFKFWALKMIDSWGLLPSGMLAGNWWNLGNFDEC 132

  Fly   126 LSEGGMLTSSQDIQGKYCFMELPVAKWLGFTSELLAVTNIRTAVCLPSSCSAGTMELFLKQLLKR 190
            ::....:|||..|:||||..:|..|      ..||.:..:::|||.|::|||..|:..|::|.::
  Fly   133 IAIDHAVTSSHSIKGKYCITKLTPA------PSLLPILALKSAVCFPATCSAANMDTMLRRLFQK 191

  Fly   191 LLGVSDPTNLFSISETSCRIKEKAPWDGLTIFTVVLLSVFGVTVILCTLYDYFLCPEQEKLPRPI 255
            ||.|....::..::|.:|:...|.|:|||.|||:|::|:.|..|.:||::|||.|.:::.:...:
  Fly   192 LLTVEIDADVQIVAEETCQTAVKKPYDGLAIFTIVIVSILGAIVGVCTIFDYFFCKDEKTIHPVV 256

  Fly   256 GAFSARATSRSLFTIVENTANPNVIHCLNGMRCMSLIWVILSHEYIINMKGPAINPADNLRWATQ 320
            .||||||.||:||.||:..||||||.||:|:||:|.|||:..|:|::....|.||....|.|...
  Fly   257 EAFSARANSRALFRIVDTKANPNVIDCLHGIRCLSFIWVVYGHDYMVLATSPNINMGYLLTWINS 321

  Fly   321 LFSSFILYGTLSVDTFFFISGLLLVSIGLRSIEKNKGKLNVPLMYLHRYLRLTPIVAVAILAFYK 385
            .:|.|:.:...:||:|||:||||||.|.|||:::.|||||:||||||||||||||:|:|||.:.|
  Fly   322 FYSLFVKHAVYAVDSFFFLSGLLLVVIALRSMDRTKGKLNIPLMYLHRYLRLTPILAIAILFYMK 386

  Fly   386 MIPLIADGPMYDDIGFFDYSGCKMTWYWTLLYVQNYATSDVCVPHTWYLAVDMQLYILSPILLIA 450
            ::||...||:...|.|.|||.|:.||||||||||||||..:|:.|:|||||||||||.:|.|||.
  Fly   387 ILPLWESGPLKGSISFDDYSACESTWYWTLLYVQNYATDSLCLSHSWYLAVDMQLYIFAPFLLIC 451

  Fly   451 LYKWGKKAAGGILVVTLLLSACLFATIMVNDFPVMFKNGIQAQVVQRKIYTATHTHAAPWLVGTM 515
            |||||||||.||.|:.|||:.|||:.:::||  :...:|..:   .||:|.||.|.|:|:|:|.:
  Fly   452 LYKWGKKAAAGIFVLMLLLAGCLFSIMVIND--LSLGSGGDS---MRKLYYATQTRASPYLIGIL 511

  Fly   516 FGYLLHLMRGRRFKLSLLATWAGWLLCLAPLFTSIFALYPYSKLLGKSPSVLQGALYYTLVRIAW 580
            |||.||..||:.|||:.||...|||:.|:.:.:.:|::|..:.|     .:::.|.|.:|.||||
  Fly   512 FGYFLHTNRGKDFKLNRLAVLLGWLIALSLIASCLFSIYGQNTL-----PIVEEAFYVSLTRIAW 571

  Fly   581 PLGLCWVVFACMQGYGSLANSFLSSPLWQPLSKLSYGAYIWHIFVVEVANRSVQTNTYFSNYQVM 645
            ||||||||||||.|||.||||.||||||||||:|||.|||:|:|:..:......|:||||:||||
  Fly   572 PLGLCWVVFACMHGYGGLANSLLSSPLWQPLSRLSYSAYIFHMFIESLNGGITHTSTYFSDYQVM 636

  Fly   646 LNFWSTFGFTLLMSYVLYVLIEAPLEALERIMFPNRRSPPAAKDQLHIESRTEVV 700
            |.||:.||||:|.||::::|||||...||.::.|.:|  |.||....:|.|...|
  Fly   637 LRFWTDFGFTILFSYLMHILIEAPFAGLESLLLPAKR--PNAKPAAVVEPRMSEV 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14204	NP_001259710.1	NRF	94..209	CDD:214781	45/114 (39%)
		Acyl_transf_3	280..664	CDD:280013	212/383 (55%)
		OafA	283..687	CDD:224748	220/403 (55%)
CG14219	NP_608322.1	NRF	101..211	CDD:214781	46/115 (40%)
		Acyl_transf_3	281..654	CDD:280013	212/382 (55%)
		OafA	326..683	CDD:224748	206/368 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458035
Domainoid	1	1.000	50	1.000	Domainoid score	I11639
eggNOG	1	0.900	-	-		E1_KOG3700
Homologene	1	1.000	-	-		H129774
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4016
Isobase	1	0.950	-	0	Normalized mean entropy	S7984
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm25504
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
	13	12.750