DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14204 and CG3106

DIOPT Version :9

Sequence 1:	NP_001259710.1	Gene:	CG14204 / 32950	FlyBaseID:	FBgn0031032	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001285060.1	Gene:	CG3106 / 31909	FlyBaseID:	FBgn0030148	Length:	742	Species:	Drosophila melanogaster

Alignment Length:	751	Identity:	250/751 - (33%)
Similarity:	374/751 - (49%)	Gaps:	83/751 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLAILLAMGMAMVQGALPTQLSNNQWTQHDVSSMADYERLLDLRSLAMEFYREFRNISTADVHLL 68
            :||::|.:..|:  ||..|. ||...|.|..             .||..|..:|..:::.... |
  Fly     7 VLAVVLLIATAV--GAQDTS-SNYLLTGHST-------------PLASSFAHQFFTLASQSAE-L 54

  Fly    69 GERIGSQDLQ-----------CLADMAQFMSALSAPKAWALKMLDAWGTIPSGYLIGNRVDMGNY 122
            ..|..:|.:|           |..|:.....:::..:.|||:..|.||.:|.|...|:.:.||.|
  Fly    55 ANRTNTQVIQTYEDRNYDDELCDRDINLIRDSINNLEEWALEFPDTWGRLPMGLFWGHTISMGQY 119

  Fly   123 RECLSEGGMLTSSQDIQGKYCFMELPVAKWLGFT----SELLAVTNIRT-------AVCLPSSCS 176
            .||::...  |.:.:|:|:||...|.:..:....    .|...::..:|       .:|:|.:||
  Fly   120 EECVAASS--THTTEIRGQYCLASLNITTFYQSVKKRGEEFSRISYKQTDPEVFELGICVPKTCS 182

  Fly   177 AGTMELFLKQLLKRLLGVSD--PTNLFSISETSCRIKEKAPWDGLTIFTVVLLSVFGVTVILCTL 239
            |...|..||..:....| .|  .:|...::|..|:........|:.||.::..|:....::..::
  Fly   183 AAKTEKLLKYAITHFYG-QDVMESNYTMVTEARCKYDAPIELRGIDIFAIIFFSLIIFFMVASSV 246

  Fly   240 YDYFLCPEQEKLPRP----IGAFSARATSRSLFTIVENTANPNVIHCLNGMRCMSLIWVILSHEY 300
            |||.    |.:...|    :.|||....:..:|| |:...||||||||||:||.|::||:..|.|
  Fly   247 YDYI----QTRKGAPKKPLLIAFSVLTNAPKIFT-VKKVNNPNVIHCLNGLRCFSMMWVVFGHGY 306

  Fly   301 IINMKGPAINPADNLRWATQLFSSFILYGTLSVDTFFFISGLLLVSIGLRSIEKNKGKLNVPLMY 365
            :.....|.||......|....:|..:..|:|.||||||:||||:.....|.:|:.|||||:|:||
  Fly   307 MTFYDLPHINKNKFYTWVQTPYSMLVQNGSLCVDTFFFMSGLLMCWGAFREMERTKGKLNIPMMY 371

  Fly   366 LHRYLRLTPIVAVAILAFYKMIPLIADGPMYDDIGFFDYSGCKMTWYWTLLYVQNYA-TSDVCVP 429
            .|||:||||:|||.:|....:......|||:..:|..| ..|..||:.||:|||||| ...:|:.
  Fly   372 FHRYIRLTPVVAVVVLYIMSLYKYSGAGPMWFKLGTQD-KRCADTWWATLIYVQNYAFPYSICIS 435

  Fly   430 HTWYLAVDMQLYILSPILLIALYKWGKKAAGGILVVTLLLSACLFATIMVNDFPVMFKNGIQAQV 494
            .:||||||.|||.|||:.||.|:||||||...|::|.:|.....|||.|:|||.:......|..:
  Fly   436 QSWYLAVDTQLYFLSPLFLIPLWKWGKKALVPIVIVLILCLGGTFATFMLNDFTLFRVQDDQVDL 500

  Fly   495 VQRKIYTATHTHAAPWLVGTMFGYLLHLM-RGRRFKLSLLATWAGWLLCLAPLFTSIFALYPYSK 558
            .||..|..|||....||:|.:|||.|... |||:..:|......||.:....:...::.  ||.:
  Fly   501 RQRLTYYPTHTRIPTWLIGVIFGYFLFTRNRGRQIPMSKPLVLTGWFVAFGTMLACMWG--PYWR 563

  Fly   559 LLGKSPS--VLQGALYYTLVRIAWPLGLCWVVFACMQGYGSLANSFLSSPLWQPLSKLSYGAYIW 621
            :|..:|.  :::||.:..|.|.:|.|.:.|:|:||..|:|.|.|.|||...:...|:|.|..|:.
  Fly   564 ILPDTPDSPLIEGAFFEPLSRTSWALSIGWIVWACYNGHGGLVNDFLSWGFFTGFSRLCYCMYVI 628

  Fly   622 HIFVVEVANRSVQTNTYFSNYQVMLNFWSTFGFTLLMSYVLYVLIEAPLEALERIMF----PNRR 682
            |..|..|....:||:|:||||..:|.:|..||.||..|....:..|||:..:|:.:|    |.:.
  Fly   629 HRIVQLVNAARLQTDTHFSNYDAILRWWHDFGITLTASIFATLAFEAPILGIEKAIFGKPAPKKP 693

  Fly   683 SP-------------------PAAKDQLHIESRTEV 699
            ||                   |.||.:..:|::||:
  Fly   694 SPGELAKAAPVAATSASAEPEPEAKPESVVETKTEI 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14204	NP_001259710.1	NRF	94..209	CDD:214781	34/127 (27%)
		Acyl_transf_3	280..664	CDD:280013	161/387 (42%)
		OafA	283..687	CDD:224748	167/430 (39%)
CG3106	NP_001285060.1	NRF	91..217	CDD:214781	35/128 (27%)
		Acyl_transf_3	286..635	CDD:280013	146/351 (42%)
		OafA	289..702	CDD:224748	166/415 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458069
Domainoid	1	1.000	50	1.000	Domainoid score	I11639
eggNOG	1	0.900	-	-		E1_KOG3700
Homologene	1	1.000	-	-		H129774
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4016
Isobase	1	0.950	-	0	Normalized mean entropy	S7984
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm25504
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
	13	12.750