DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14204 and oac-14

DIOPT Version :9

Sequence 1:	NP_001259710.1	Gene:	CG14204 / 32950	FlyBaseID:	FBgn0031032	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_509701.1	Gene:	oac-14 / 181226	WormBaseID:	WBGene00008602	Length:	710	Species:	Caenorhabditis elegans

Alignment Length:	764	Identity:	206/764 - (26%)
Similarity:	327/764 - (42%)	Gaps:	170/764 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIKLLAILLAMGMAM------------VQGALPTQLSNNQ-WTQHDVSSMADYERLLDLRSLAME 52
            :.|::.:||:...|:            :.|..|..|::.| |                ::||.:
Worm     4 LFKVVLLLLSTSGAVTLDWKDIFKPKPLHGLSPQCLNDTQTW----------------IKSLEL- 51

  Fly    53 FYREFRNISTADVHLLGERIGSQDLQCLADMAQFMSALSAPKA--WALKMLDAWGTIP-SGYLIG 114
                |..:|.|               ||......:..|...||  :|::.||::|.:| .|.|..
Worm    52 ----FAGVSEA---------------CLKKQTCSLKELKILKANLYAIQELDSFGKLPVPGMLEV 97

  Fly   115 NRVDMGNYRECLSEGGMLTSSQDIQGKYCFMELPVAK----WLGFTSELLAVTNIRTAVCLPSSC 175
            ..:..|:|:||....|:..::     .||::.|...|    ....:|...::..:|.|||||.||
Worm    98 ATLYDGSYQECKRVSGVKYNT-----NYCYLMLKPGKNASCSASGSSSAYSMLPMRLAVCLPDSC 157

  Fly   176 SAGTMELFLKQLLKRLLGVSDPTNLFSISETSC---RIKEKAPWDGLTIFTVVLLSVFGVTVILC 237
            :...:.....||        .|.. |:.....|   .:|:..|:.|.:||.:|::    |..:..
Worm   158 NQHEIIDIFNQL--------SPYP-FTACHAYCSEYEVKKDTPFWGFSIFLIVMV----VIALAA 209

  Fly   238 TLYDYF--------LCPEQEKLPRPIGAFSARATSRSLFTIVENTANPNVIHCLNGMRCMSLIWV 294
            :|.||.        ...|:....:.:.:||....:..|.::.|.  .|..|..|:.:|..|:.||
Worm   210 SLTDYIRDTVYGIKSIKERNVFLKILLSFSLWTNAELLLSVKEQ--KPGFIKSLDCIRLFSMCWV 272

  Fly   295 ILSHEYIINMKGPAINPADNLR---WATQLFSSFILYGTLSVDTFFFISGLLLVSIGLRSIEKNK 356
            :..|.:|..:......|..:..   |...|.::|:     ||||||.:|||:|..:..::..|.|
Worm   273 VTGHSFIYLVLSDTFMPVIDFPKHFWNHLLLNAFV-----SVDTFFVLSGLVLTYMFFKTTPKKK 332

  Fly   357 GKLNVP----LMYLHRYLRLTPIVAVAILAFYKMIPLIADGPMYDDIGFFDYS----------GC 407
            ..:| |    :.|:||||||||.:.:.|..|....|.| .||       |..|          .|
Worm   333 MIVN-PVTWIMFYVHRYLRLTPPIMLFIGFFTVYAPYI-QGP-------FSASQMNQLVMEADEC 388

  Fly   408 KMTWYWTLLYVQNYATSDV--CVPHTWYLAVDMQLYILSPILLIALY-----KWGKKAAG--GIL 463
            |.||:..|||:.::|:|:.  |...|||||||.|||:::||:||.||     ..|...||  |.:
Worm   389 KTTWWQNLLYINDFASSNSMGCYGPTWYLAVDTQLYLVAPIVLIGLYFSFAVGTGLIVAGCVGSI 453

  Fly   464 VVTLLLSACLFATIMVNDFPV-MFKNGIQAQVVQRKIYTATH----THAAPWLVGTMFGYLLHLM 523
            :.|.:|       ..|.:.|. ||.||...     ..:|..:    ....|:|||.:.||||.:.
Worm   454 ITTYIL-------FSVYNLPADMFGNGSGT-----NFFTIAYEKPWVRCPPYLVGMLTGYLLAVY 506

  Fly   524 RGRRFKLSLLATWAGWLLCLAPLFTSIFALYPYSKLLGKSPSVLQGALYYTLVRIAWPLGLCWVV 588
            ..|:.:|:.:.:.|||::.:......:||.|.|.|  |...||.....:|...|:.|.:.:||||
Worm   507 GNRKIRLNWVLSLAGWIIAVVIAGFCLFATYDYDK--GSHWSVFTRGTFYNFHRLGWGMFICWVV 569

  Fly   589 FACMQGYGSLANSFLSSPLWQPLSKLSYGAYIWH-IFVVEVANRSVQTNTYFSNYQVMLNFWSTF 652
            .|...|:|...:.|:|.|:|||..:|||.|||.| :.:....|.......|:|..:|       |
Worm   570 AANHMGWGGPIDKFMSHPIWQPFGRLSYCAYIVHWVVLFWFLNVGGHATHYYSALEV-------F 627

  Fly   653 GFTLL----MSYVL----YVLIEAPLEALERIMF--------PNRRSPP 685
            .:|.:    :||:.    ..|.|.|...||:::.        |:.:..|
Worm   628 TYTSIPATFLSYIFAFFWSCLFEIPTLKLEKMLIEAILGTGRPSNKVEP 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14204	NP_001259710.1	NRF	94..209	CDD:214781	32/124 (26%)
		Acyl_transf_3	280..664	CDD:280013	134/423 (32%)
		OafA	283..687	CDD:224748	140/451 (31%)
oac-14	NP_509701.1	NRF	76..183	CDD:214781	30/120 (25%)
oac-14	NP_509701.1	OafA	252..656	CDD:224748	139/440 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	204	1.000	Domainoid score	I1719
eggNOG	1	0.900	-	-		E1_KOG3700
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	238	1.000	Inparanoid score	I2120
Isobase	1	0.950	-	0	Normalized mean entropy	S7984
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14368
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.680