DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14204 and nrf-6

DIOPT Version :9

Sequence 1:	NP_001259710.1	Gene:	CG14204 / 32950	FlyBaseID:	FBgn0031032	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_495680.1	Gene:	nrf-6 / 174287	WormBaseID:	WBGene00003813	Length:	822	Species:	Caenorhabditis elegans

Alignment Length:	785	Identity:	191/785 - (24%)
Similarity:	332/785 - (42%)	Gaps:	179/785 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SMADYERLLDLRSLAMEFYREFRNISTA--------DVHLLG------ERIGSQDLQ--CLADM- 83
            |.:|.:.:|||     :|:|.|.|.:.|        ::.|:.      |::.|.|:.  |:.||
Worm    57 SDSDAQLILDL-----DFFRHFFNYAEAYRDGAEEGNLELMKYAVEMVEKLKSFDISMACVGDMM 116

  Fly    84 ------------------------AQFMSALSAPKAWALKMLDAWGTIPSGYLIGNRVDMGNYRE 124
                                    ........:.:.|...:.||.|.:|:|.:.||.:.:|::..
Worm   117 HLAWTGVEYATHVEEHKNCSDCKCTPLFQQKKSERHWIFNVFDAMGKVPAGIMSGNNLWVGSWST 181

  Fly   125 CL-------SEGGMLTSSQDIQGKYC------------------FMELPVAKWL----------- 153
            |.       ::|      |..:|:||                  .|..|..|..
Worm   182 CRKIDVVKNAQG------QKWKGQYCLATIDAYERDNPLVYFGNMMSGPPDKHCYDKTVKNVTDD 240

  Fly   154 GFTSELLAVTNIRTAVCLPSSCSAGTMELFLKQLLKRLLGVSDPTNLFSISETSCRIK---EKAP 215
            ||...|..|  ::..||:|::|:...::..|...::...|.....::.:: :..||.:   :...
Worm   241 GFCFALFPV--LKFGVCMPNTCTNHDVKQMLSFAIRATEGAVGTKSVCNV-DVECRAESYSDAMS 302

  Fly   216 WDGLTIFTVVLLSVFGVTVILCTLYDYFL---CPEQEK----LPRPIGAFSARATSRSLFT---- 269
            .:||.:|.:.||....|.|...||||.|:   .|:.||    ...|...|   ..:.|::|
Worm   303 ENGLAMFALYLLIATVVLVTFGTLYDLFIVSKAPQDEKNSSAFNHPFIKF---ILAFSMYTNGSE 364

  Fly   270 IVENTANPNVIHCLNGMRCMSLIWVILSHEYIINMKGPAINPADNL-----RWATQLFSSFILYG 329
            |:::..|...|:.|:|:|.:|:.|:||.|.|.  ..|.::. .|||     .:..|..:..|:..
Worm   365 ILQSKKNDREINSLHGVRFLSMCWIILGHTYY--YIGTSLT-TDNLVPTLINFPKQFHTQIIVQA 426

  Fly   330 TLSVDTFFFISGLLLVSIGLRSIEK----NKGKLNV------PLMYLHRYLRLTPIVAVAILAFY 384
            .|:||:|||:||:|......:...|    :..||:.      |:.|..||:|:||...:.:|...
Worm   427 PLAVDSFFFLSGMLAAFSFFKKTMKADPNHPPKLSAFNWQTWPMYYYKRYIRITPTYIIVMLFDV 491

  Fly   385 KMIPLIADGPMYDDIGFFDYSGCKMTWYWTLLYVQNYATSD--VCVPHTWYLAVDMQLYI-LSPI 446
            .:...|::||.:..|   :..||.:.|:..|:|:.|:...|  .|:..|||||.|||.:| |.|:
Worm   492 TLFTYISNGPFWRPI---ERQGCSIAWWTNLIYLNNFLLQDQECCMGWTWYLANDMQFHIFLMPL 553

  Fly   447 LLIALYKWGKKAAGGI------------LVVTL--------LLSACLFATIMVNDFPVMFKNGIQ 491
            |:|...|||.|...|:            |::|.        :|:|.|.....:||:
Worm   554 LVIVFLKWGMKVGLGLSTGLIALSSLIRLIITQIYGYPPAPILTAKLQIVYQLNDY--------- 609

  Fly   492 AQVVQRKIYTATHTHAAPWLVGTMFGYLLHLMRGR-----RFKLSLLATWAGWLLCLAPLFTSIF 551
                ...:|...:....|::||.:..|||:....|     :.||........|.........|:|
Worm   610 ----WNDVYVRPYIRCTPFIVGIVVAYLLNAWTTREQKDLKIKLERRTVIICWCTSTVLGLYSVF 670

  Fly   552 ALYPYSKL--LGKSPSVLQGALYYTLVRI-AWPLGLCWVVFACMQGYGSLANSFLSSPLWQPLSK 613
            .||.::|.  :.|...:|     ||:... |:.|.|.||||||..|.|...::.||..|:.||||
Worm   671 GLYWFAKTGDISKPWEIL-----YTIFGTPAYALALGWVVFACTTGNGGPVDTILSWRLFVPLSK 730

  Fly   614 LSYGAYIWHIFVVEVANRSVQTNTYFSNYQVMLNFWSTFGF-TLLMSYVLYVLIEAPLEALERIM 677
            :::.||:.|..::::.|.|.....:|:.:..|:.:.....| :..:::...:..|.||..::.::
Worm   731 ITFCAYLLHPIMLQIYNLSRPQPFHFTTFIQMIRYTVEAVFASYTIAFFFSLAFEKPLNKIDEML 795

  Fly   678 FPNRR 682
            |.:::
Worm   796 FNSKK 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14204	NP_001259710.1	NRF	94..209	CDD:214781	28/150 (19%)
		Acyl_transf_3	280..664	CDD:280013	119/430 (28%)
		OafA	283..687	CDD:224748	122/447 (27%)
nrf-6	NP_495680.1	NRF	151..288	CDD:214781	28/144 (19%)
		OafA	375..790	CDD:224748	122/438 (28%)
		Acyl_transf_3	375..777	CDD:280013	119/425 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162769
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7984
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm14368
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.600