Protein Alignment HSD17B4 and ScpX

DIOPT Version :10

• Sequence 1: NP_001186220.1
• Gene: HSD17B4 / 3295
• HGNCID: 5213
• Length: 761
• Species: Homo sapiens
• Sequence 2: NP_524715.2
• Gene: ScpX / 44183
• FlyBaseID: FBgn0015808
• Length: 544
• Species: Drosophila melanogaster
• Alignment Length: 660
• Identity: 143/660 - (21%)
• Similarity: 217/660 - (32%)
• Gaps: 262/660 - (39%)

Human   172 IMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKSNIHCNTIAPNAGSRMTQTVMPEDLVE 236
            :..:.|..:||:......:..::|:.|      |.....|.:|:|     ||  :...:.:.:||
  Fly    49 VQQAVAGYVYGDSTCGQRAIYEVGMTG------IPVYNVNNNCST-----GS--SALYLAKQIVE 100

Human   237 ALKPEYVAPLVLWLCHESCE--------------------ENGGLFEVGAG-------------- 267
            :..    |..||.|..|..|                    |.|.|.|:|||
  Fly   101 SGN----ADCVLALGFEKMERGSLSSKYFDRANPMERHITEMGELAEIGAGPMAAQIFGNAGKEH 161

Human   268 ---------WIGKLRWERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEV 323
                     ..||:.|          |||..:.....:.::.....|...|...:.|.      |
  Fly   162 MKKYGTKPEHFGKIAW----------KNHKHSVNNPYSQFRDEYTLEQIMKSPQVVEG------V 210

Human   324 LSKID----SEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASI-KDP 383
            |:|:.    |:|       |.|...|:..|....|          .|.:|:..   ||..: .||
  Fly   211 LTKLQCCPTSDG-------SGAAILASEAFVRRHG----------LEKQAVEI---VGMEMASDP 255

Human   384 KDLKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIPGLSIN-------FAKVLHGEQYLELYKP 441
                     :|.|:          .||:|     :|.|..:.       |||        ..|||
  Fly   256 ---------ASTFA----------DKSLM-----KIAGTDMTRLATQRLFAK--------SGYKP 288

Human   442 LPRAGKLKCEAVVADVLDKGSGVVIIMDVYSYSEKELICHNQFSLFLVGSGG---------FGGK 497
                         .||     .||.:.|  .:|..|||.:....|...|:.|         :|||
  Fly   289 -------------QDV-----QVVELHD--CFSANELITYEALGLCGEGNAGEFIDAGDNTYGGK 333

Human   498 RTSDKVKVAVAIPNRPPDAVLT-----DTTSLNQAA--LYRLSGDWNPLHIDPNFASLA-----G 550
            ...:           |...:::     ..|.|.|.|  .::|.|......: || |.||     |
  Fly   334 FVVN-----------PSGGLISKGHPLGATGLAQCAELCWQLRGLAEKRQV-PN-AQLALQHNLG 385

Human   551 FDKPILHGLCTFGFSARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKV 615
            ....::..|...||.|
  Fly   386 LGGAVVVALYRLGFPA------------------------------------------------- 401

Human   616 QETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTF-VFEEIGRRLKDIGPEVVKKVNAVFEWHI 679
               .:.|:.|.      |:...|.|..:|.|:.... :.|:..:..||   .:::||.|::.:.:
  Fly   402 ---ANSVVRNL------TAAGKAATSEDGFKVAPLLKLLEQAMQEDKD---NLIEKVRAIYGFKV 454

Human   680 TKG--GNIGAKWTIDLKSGSGK-VYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKA 741
            ..|  |..|. |.||.|.|.|| ::.|..|  .|.|.|:||:|..|::.|||.||||||.|::|.
  Fly   455 NNGPNGQTGF-WVIDAKQGKGKIIFNGTQK--CDVTFIISDDDVFELLTGKLPPQKAFFQGKIKI 516

Human   742 RGNIMLSQKL 751
            :||:..:.||
  Fly   517 QGNMGFAMKL 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSD17B4	NP_001186220.1	hydroxyacyl-CoA-like_DH_SDR_c-like	61..279	CDD:187611	29/149 (19%)
		PLN02864	353..630	CDD:178455	54/305 (18%)
		SCP2	653..756	CDD:460423	40/102 (39%)
ScpX	NP_524715.2	PRK08256	5..396	CDD:181327	93/464 (20%)
		SCP2	428..531	CDD:460423	40/105 (38%)