Protein Alignment HSD17B4 and Hsdl2

DIOPT Version :10

• Sequence 1: NP_001186220.1
• Gene: HSD17B4 / 3295
• HGNCID: 5213
• Length: 761
• Species: Homo sapiens
• Sequence 2: NP_651578.1
• Gene: Hsdl2 / 43325
• FlyBaseID: FBgn0039537
• Length: 412
• Species: Drosophila melanogaster
• Alignment Length: 687
• Identity: 113/687 - (16%)
• Similarity: 186/687 - (27%)
• Gaps: 353/687 - (51%)

Human    85 EEIRRRGGKAVANYDSVEEGEKV---VKTALDAFGRIDVVVNNAGILRDRSFARISDED---WDI 143
            |||.:.||||......|.:.::|   |:.|:..||.||:|:|||..:   |.....|.|   :|:
  Fly    58 EEIEKAGGKAYPCVVDVRDEQQVRSAVEAAVAKFGGIDIVINNASAI---SLTNTPDTDMKRYDL 119

Human   144 IHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGR 208
            :|.::.||:|.|::....::||..:..|:
  Fly   120 MHNINTRGTFLVSKVCLPYLKKSNHAHIL------------------------------------ 148

Human   209 KSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLR 273
                   .|:|..               ::||:                          |.|
  Fly   149 -------NISPPL---------------SMKPK--------------------------WFG--- 162

Human   274 WERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLSKIDSEGGVSANHT 338
                                                                             
  Fly   163 ----------------------------------------------------------------- 162

Human   339 SRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKDLKFIYEGSSDFSCLPTFG 403
                               |..:|...:....|..||:.|..||
  Fly   163 -------------------PHVAYTMAKYGMSMCVLGMAAEFKD--------------------- 187

Human   404 VIIGQKSMMGGGLAEIPGLSINFAKVLHGEQYLELYKPLPRAGKLKCEAVVADVLDKGSGVVIIM 468
                            .|:|:|
  Fly   188 ----------------EGISVN------------------------------------------- 193

Human   469 DVYSYSEKELICHNQFSLFLVGSGGFGGKRTSDKVKVAVAIPNRPPDAVLTDTTSLNQAALYRLS 533
                                                            .|...|:::.||:..|:
  Fly   194 ------------------------------------------------ALWPRTAIHTAAIEMLT 210

Human   534 GDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQ----FADNDVSRFKAIKARFAKPVYP 594
            |        |:.|..:  .||.:.....:....|...|.    |.|::|.....|
  Fly   211 G--------PDSAKWS--RKPEIMADAAYAILTREPRQSTGQFFVDDEVLESAGI---------- 255

Human   595 GQTLQTE---MWKEGNRIHFQTKVQETGDIVISNAYVD--LAPTSGTSAKTPSEGGKLQSTFVFE 654
              |..||   ..:..:::.....|:|.|..|.:.|..:  .||.||...|.|....|::|.
  Fly   256 --TDLTEYACFRENADKLMVDFFVEEKGAPVENEAAAEDAAAPASGGDVKIPQLFRKIESL---- 314

Human   655 EIGRRLKDIGPEVVKKVNAVFEWHITKGGNIGAKWTIDLKSGSGKVYQGPAKGAADTTIILSDED 719
                    :.||:|.|..|||:::|: |...|. |.:|||:|||....|....|.|.|:.::.::
  Fly   315 --------LSPEIVSKTQAVFQFNIS-GAEQGT-WFLDLKNGSGSCGAGTPTAAPDATLTMNSKN 369

Human   720 FMEVVLGKLDPQKAFFSGRLKARGNIMLSQKLQMILK 756
            |.::..|||....|:.:|:||..|:...:.||:.::|
  Fly   370 FFDMFSGKLKAAPAYMTGKLKISGDFQKALKLEKLMK 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSD17B4	NP_001186220.1	hydroxyacyl-CoA-like_DH_SDR_c-like	61..279	CDD:187611	37/199 (19%)
		PLN02864	353..630	CDD:178455	35/285 (12%)
		SCP2	653..756	CDD:460423	32/102 (31%)
Hsdl2	NP_651578.1	PRK08278	7..277	CDD:181349	67/542 (12%)
		SCP2	306..408	CDD:442486	35/115 (30%)