DRSC/TRiP Functional Genomics Resources

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Protein Alignment HSD17B4 and Mfe2

DIOPT Version :9

Sequence 1:NP_001186220.1 Gene:HSD17B4 / 3295 HGNCID:5213 Length:761 Species:Homo sapiens
Sequence 2:NP_001285318.1 Gene:Mfe2 / 32582 FlyBaseID:FBgn0030731 Length:598 Species:Drosophila melanogaster


Alignment Length:578 Identity:292/578 - (50%)
Similarity:393/578 - (67%) Gaps:33/578 - (5%)


- Green bases have known domain annotations that are detailed below.


Human    61 VSMNDLGGDFKGVGKGSLAADKVVEEIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNA 125
            |.:|||||...|.|....|||.||:|||:.||:|||:|:||.:|.||::||:.||||:|::||||
  Fly    39 VVVNDLGGTHSGDGASQRAADIVVDEIRKAGGEAVADYNSVIDGAKVIETAIKAFGRVDILVNNA 103

Human   126 GILRDRSFARISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYS 190
            |||||||..:.|::||::::.|||:|||:.|:||:.:||||.|||||||||.|||||||||.||:
  Fly   104 GILRDRSLVKTSEQDWNLVNDVHLKGSFKCTQAAFPYMKKQNYGRIIMTSSNSGIYGNFGQVNYT 168

Human   191 AAKLGLLGLANSLAIEGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESC 255
            |||:||:||||::||||.::|:.||.|.|.|.||||:.::|:.|...|||:.:||:|.:||||||
  Fly   169 AAKMGLIGLANTVAIEGARNNVLCNVIVPTAASRMTEGILPDILFNELKPKLIAPVVAYLCHESC 233

Human   256 EENGGLFEVGAGWIGKLRWERTLGAIVRQK-NHPMTPEAVKANWKKICDFENASKPQSIQESTGS 319
            |:||...|..|||..||...|..||::|.. :.|:|.|.||..|..:.|...|....:|.|::|:
  Fly   234 EDNGSYIESAAGWATKLHMVRGKGAVLRPSLDDPVTIEYVKDVWSNVTDMSKAKHLGAIAEASGT 298

Human   320 IIEVLSKIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPK 384
            ::|||.|:...||.:...                       ::.:...|.|.||||:|||:|:.|
  Fly   299 LLEVLEKLKEGGGDAIED-----------------------AFEFNSKELITYALGIGASVKNAK 340

Human   385 DLKFIYEGSSDFSCLPTFGVIIGQKSMMGGG--LAE-IPGLSINFAKVLHGEQYLELYKPLPRAG 446
            |::|:||..:||:.:|||.|:.|....|...  |:: :|...::|:.:||||||||:...||.:|
  Fly   341 DMRFLYENDADFAAIPTFFVLPGLLLQMSTDKLLSKALPNSQVDFSNILHGEQYLEIVDDLPTSG 405

Human   447 KLKCEAVVADVLDKGSGVVIIMDVYSYSEK-ELICHNQFSLFLVGSGGFGGKRTSDKVKVAVAI- 509
            .|.....|.||:|||||.|::.:..|:.|. .|:..||.:.|:||:|.||||:  |.:...|.: 
  Fly   406 TLLTNGKVFDVMDKGSGAVVVTNSESFDESGRLLVRNQSTTFIVGAGKFGGKK--DPIAGVVPLQ 468

Human   510 --PNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQ 572
              |||.|||.:..|||.:||||||||||.|||||||..|.||||..||||||||.|||.|.||.|
  Fly   469 PAPNRQPDATVQYTTSEDQAALYRLSGDKNPLHIDPQMALLAGFKTPILHGLCTLGFSVRAVLAQ 533

Human   573 FADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDL 630
            ||||:.:.|||:|.||:.||.|||||:.::||:|.||:|:|.|.|||..|||.|||||
  Fly   534 FADNNPALFKAVKVRFSGPVIPGQTLRVDLWKQGTRINFRTVVVETGKEVISGAYVDL 591

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HSD17B4NP_001186220.1 hydroxyacyl-CoA-like_DH_SDR_c-like 61..279 CDD:187611 128/217 (59%)
PLN02864 353..630 CDD:178455 142/283 (50%)
hot_dog <400..468 CDD:294345 30/70 (43%)
HDE_HSD 510..631 CDD:239532 82/121 (68%)
SCP2 653..756 CDD:280250
Mfe2NP_001285318.1 hydroxyacyl-CoA-like_DH_SDR_c-like 8..257 CDD:187611 128/217 (59%)
PRK07791 11..248 CDD:236099 125/208 (60%)
PLN02864 315..598 CDD:178455 144/302 (48%)
hot_dog <383..442 CDD:294345 25/58 (43%)
HDE_HSD 471..592 CDD:239532 82/121 (68%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159303
Domainoid 1 1.000 253 1.000 Domainoid score I2085
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H358
Inparanoid 1 1.050 613 1.000 Inparanoid score I911
Isobase 1 0.950 - 0.861654 Normalized mean entropy S1547
OMA 1 1.010 - - QHG51914
OrthoDB 1 1.010 - - D1120431at2759
OrthoFinder 1 1.000 - - FOG0005261
OrthoInspector 1 1.000 - - oto90968
orthoMCL 1 0.900 - - OOG6_101391
Panther 1 1.100 - - LDO PTHR13078
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2120
SonicParanoid 1 1.000 - - X3784
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1514.890

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