Protein Alignment HSD17B4 and Mfe2

DIOPT Version :10

• Sequence 1: NP_001186220.1
• Gene: HSD17B4 / 3295
• HGNCID: 5213
• Length: 761
• Species: Homo sapiens
• Sequence 2: NP_573109.1
• Gene: Mfe2 / 32582
• FlyBaseID: FBgn0030731
• Length: 598
• Species: Drosophila melanogaster
• Alignment Length: 578
• Identity: 292/578 - (50%)
• Similarity: 393/578 - (67%)
• Gaps: 33/578 - (5%)

Human    61 VSMNDLGGDFKGVGKGSLAADKVVEEIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNA 125
            |.:|||||...|.|....|||.||:|||:.||:|||:|:||.:|.||::||:.||||:|::||||
  Fly    39 VVVNDLGGTHSGDGASQRAADIVVDEIRKAGGEAVADYNSVIDGAKVIETAIKAFGRVDILVNNA 103

Human   126 GILRDRSFARISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYS 190
            |||||||..:.|::||::::.|||:|||:.|:||:.:||||.|||||||||.|||||||||.||:
  Fly   104 GILRDRSLVKTSEQDWNLVNDVHLKGSFKCTQAAFPYMKKQNYGRIIMTSSNSGIYGNFGQVNYT 168

Human   191 AAKLGLLGLANSLAIEGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESC 255
            |||:||:||||::||||.::|:.||.|.|.|.||||:.::|:.|...|||:.:||:|.:||||||
  Fly   169 AAKMGLIGLANTVAIEGARNNVLCNVIVPTAASRMTEGILPDILFNELKPKLIAPVVAYLCHESC 233

Human   256 EENGGLFEVGAGWIGKLRWERTLGAIVRQK-NHPMTPEAVKANWKKICDFENASKPQSIQESTGS 319
            |:||...|..|||..||...|..||::|.. :.|:|.|.||..|..:.|...|....:|.|::|:
  Fly   234 EDNGSYIESAAGWATKLHMVRGKGAVLRPSLDDPVTIEYVKDVWSNVTDMSKAKHLGAIAEASGT 298

Human   320 IIEVLSKIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPK 384
            ::|||.|:...||.:...                       ::.:...|.|.||||:|||:|:.|
  Fly   299 LLEVLEKLKEGGGDAIED-----------------------AFEFNSKELITYALGIGASVKNAK 340

Human   385 DLKFIYEGSSDFSCLPTFGVIIGQKSMMGGG--LAE-IPGLSINFAKVLHGEQYLELYKPLPRAG 446
            |::|:||..:||:.:|||.|:.|....|...  |:: :|...::|:.:||||||||:...||.:|
  Fly   341 DMRFLYENDADFAAIPTFFVLPGLLLQMSTDKLLSKALPNSQVDFSNILHGEQYLEIVDDLPTSG 405

Human   447 KLKCEAVVADVLDKGSGVVIIMDVYSYSEK-ELICHNQFSLFLVGSGGFGGKRTSDKVKVAVAI- 509
            .|.....|.||:|||||.|::.:..|:.|. .|:..||.:.|:||:|.||||:  |.:...|.:
  Fly   406 TLLTNGKVFDVMDKGSGAVVVTNSESFDESGRLLVRNQSTTFIVGAGKFGGKK--DPIAGVVPLQ 468

Human   510 --PNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQ 572
              |||.|||.:..|||.:||||||||||.|||||||..|.||||..||||||||.|||.|.||.|
  Fly   469 PAPNRQPDATVQYTTSEDQAALYRLSGDKNPLHIDPQMALLAGFKTPILHGLCTLGFSVRAVLAQ 533

Human   573 FADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDL 630
            ||||:.:.|||:|.||:.||.|||||:.::||:|.||:|:|.|.|||..|||.|||||
  Fly   534 FADNNPALFKAVKVRFSGPVIPGQTLRVDLWKQGTRINFRTVVVETGKEVISGAYVDL 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSD17B4	NP_001186220.1	hydroxyacyl-CoA-like_DH_SDR_c-like	61..279	CDD:187611	128/217 (59%)
		PLN02864	353..630	CDD:178455	142/283 (50%)
		SCP2	653..756	CDD:460423
Mfe2	NP_573109.1	hydroxyacyl-CoA-like_DH_SDR_c-like	8..257	CDD:187611	128/217 (59%)
		PLN02864	315..598	CDD:178455	144/302 (48%)