DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HSD17B4 and CG11151

DIOPT Version :9

Sequence 1:	NP_001186220.1	Gene:	HSD17B4 / 3295	HGNCID:	5213	Length:	761	Species:	Homo sapiens
Sequence 2:	NP_001259531.1	Gene:	CG11151 / 32335	FlyBaseID:	FBgn0030519	Length:	115	Species:	Drosophila melanogaster

Alignment Length:	116	Identity:	57/116 - (49%)
Similarity:	77/116 - (66%)	Gaps:	4/116 - (3%)

- Green bases have known domain annotations that are detailed below.

Human   647 LQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNIGAKWTIDLKSGSGKVYQGPAKG-AAD 710
            |||..||::|...||: .....|.||.||.:.|||.|.:..:||:|.|  :.|.|:|||:| ..|
  Fly     3 LQSDAVFQKIIDGLKE-NEAKAKAVNGVFLYKITKDGKVAKEWTLDCK--NAKAYEGPAQGIKVD 64

Human   711 TTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAKL 761
            ||:.::|||.:::.||||:||.||..|:||..|||||:|||..:||..|||
  Fly    65 TTLTVADEDMVDIALGKLNPQAAFMKGKLKIAGNIMLTQKLAPLLKTDAKL 115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HSD17B4	NP_001186220.1	hydroxyacyl-CoA-like_DH_SDR_c-like	61..279	CDD:187611
		PLN02864	353..630	CDD:178455
		hot_dog	<400..468	CDD:294345
		HDE_HSD	510..631	CDD:239532
		SCP2	653..756	CDD:280250	48/103 (47%)
CG11151	NP_001259531.1	SCP2	9..109	CDD:396566	48/102 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7491
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2120
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940