DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tao and TAOK2

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	XP_011544284.1	Gene:	TAOK2 / 9344	HGNCID:	16835	Length:	1242	Species:	Homo sapiens

Alignment Length:	843	Identity:	393/843 - (46%)
Similarity:	510/843 - (60%)	Gaps:	108/843 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPS-ARPGSLKDPEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQ 64
            ||: .|.||||||::|:||.|.||||:|.||||||||||||||:||.....|:||||||||:|||
Human     1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQ 65

  Fly    65 SQEKWQDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAA 129
            |.||||||:||:|||::|.|||||:|:||||||.|||||||||:|||||::|||||||.|.||||
Human    66 SNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAA 130

  Fly   130 ICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPANSFVGTPYWMAPEVIL 194
            :..|.|.||:||||...||||:|||||||::.|:|||.|||||:|..||||||||||||||||||
Human   131 VTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVIL 195

  Fly   195 AMDEGQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSDAFCSFVEL 259
            |||||||||||||||||||||||||||||.||||||||||||||||||.|....||:.|.:||:.
Human   196 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDS 260

  Fly   260 CLKKMPAERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKILMVDTCETES 324
            ||:|:|.:||:|..||.|.:|.|.|..||:::||.|||.||||||||.||||||||..:......
Human   261 CLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPG 325

  Fly   325 AVGDTDDQQDD----------HAGGDSSKSNSITSEHSIHSVGVSAASSQSSSSNSIPAAAQN-- 377
            |....:::|..          |..|..:   |:.|.||:.|:.:| |||||||.||:..|:.|
Human   326 AEAPEEEEQPTPCSQEAEPYMHRAGTLT---SLESSHSVPSMSIS-ASSQSSSVNSLADASDNEE 386

  Fly   378 --HHHIAAHHHQQAASAAVAAAMHHHHHPHQQPPPSWPSGQQGQPVPPGAVSRNSSRHRNRPPLP 440
              .........::...|...|.|....|.                    ..|.:|..||    ||
Human   387 EEEEEEEEEEEEEGPEAREMAMMQEGEHT--------------------VTSHSSIIHR----LP 427

  Fly   441 NIMHSMNNNVTPTNSASVVPAPAPAPVLPPPISVLPHLSAMGHVGGGGTGTGGSGGGSPASGGPL 505
            ...:..::...|    .:.|:|...|..|.|.|
Human   428 GSDNLYDDPYQP----EITPSPLQPPAAPAPTS-------------------------------- 456

  Fly   506 ADRIQPVQPRYLTTPAAQAAVYAASSASSQQAISNAVNDHGPNNFATIRTTSIVTKQQKEHMQEE 570
                        ||.:|:...|..:            .||    ||||||.|:|::|.:||.|:.
Human   457 ------------TTSSARRRAYCRN------------RDH----FATIRTASLVSRQIQEHEQDS 493

  Fly   571 -MHEQMSGYKRMRREHQAHLVKLEEKCKVDMEAHKTALDKEYDTLLHNFTRDLDRLETKHQQDVE 634
             :.||:||||||||:||..|:.||.:.:.:.|.|...|.:|.:.....|..:.::|..:||...|
Human   494 ALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGE 558

  Fly   635 RRAKQTSAAEKKLHKEITLKQENDRKVYDLNRKKEYKANKERWKRELSMDESTPKRQRDLTLQSQ 699
            :.|:...|.|:|..:.|..:|:.:.......:|:.||..||:.|.||..:.|||||::...|..|
Human   559 KEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQ 623

  Fly   700 KDNLKQHEAQEEQRMLQAQKQYIELEMRKFKRKRMIMQHEHEDQQLRDELGKKEQQLQQAHAMLL 764
            |:.|:|.:|:||..:|:.|:||.||:.|::|||.::.:|..:...||::|.||:.|.....|:||
Human   624 KEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLL 688

  Fly   765 KHHEKTQELEYRQQKSVHQLREEQINKQHDTELHNQKDYMDRIKKELVRKHAVELRQQPKSLK 827
            :.||.|:|||.||.::|.:.|.|....||.|||.||.:|..|.::||.:|||.::||||||||
Human   689 RQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLK 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	192/256 (75%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	190/252 (75%)
TAOK2	XP_011544284.1	STKc_TAO2	12..319	CDD:270804	226/306 (74%)
TAOK2	XP_011544284.1	S_TKc	28..281	CDD:214567	190/252 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	410	1.000	Domainoid score	I685
eggNOG	1	0.900	-	-		E1_KOG0577
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	991	1.000	Inparanoid score	I308
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D277938at33208
OrthoFinder	1	1.000	-	-		FOG0001318
OrthoInspector	1	1.000	-	-		otm40953
orthoMCL	1	0.900	-	-		OOG6_102967
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X816
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.830