Protein Alignment Tao and CDC42BPA

DIOPT Version :9

• Sequence 1: NP_001188672.1
• Gene: Tao / 32948
• FlyBaseID: FBgn0031030
• Length: 1039
• Species: Drosophila melanogaster
• Sequence 2: NP_001374479.1
• Gene: CDC42BPA / 8476
• HGNCID: 1737
• Length: 1845
• Species: Homo sapiens
• Alignment Length: 1172
• Identity: 243/1172 - (20%)
• Similarity: 435/1172 - (37%)
• Gaps: 418/1172 - (35%)

  Fly    27 FEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDILK--EIRFLRQ-----LNH 84
            ||.|:.||.|:||.|...:.....::.|:|.::        || ::||  |....|:     :|.
Human    77 FEILKVIGRGAFGEVAVVKLKNADKVFAMKILN--------KW-EMLKRAETACFREERDVLVNG 132

  Fly    85 PN----TIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKK---PLHEDEIAAICLGVLSGLSYLH 142
            .|    |:.|  .:..::..:|||:|.||  .|::.:..|   .|.||........::..:..:|
Human   133 DNKWITTLHY--AFQDDNNLYLVMDYYVG--GDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVH 193

  Fly   143 SLGRIHRDIKAGNILLTDNGVVKLADFGSAAIK------CPANSFVGTPYWMAPEVILAMDE--G 199
            .|..:|||||..|||:..||.::|||||| .:|      ..::..||||.:::||::.||::  |
Human   194 QLHYVHRDIKPDNILMDMNGHIRLADFGS-CLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKG 257

  Fly   200 QYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSDAFCSFVELCLKKM 264
            :|..:.|.||||:                   .:|.:...|:|...:        |.||
Human   258 RYGPECDWWSLGV-------------------CMYEMLYGETPFYAE--------SLVE------ 289

  Fly   265 PAERPSSAKLLTH-------AYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKILMVDTCET 322
                 :..|::.|       |.||         ::....|..:|.|               .|..
Human   290 -----TYGKIMNHKERFQFPAQVT---------DVSENAKDLIRRL---------------ICSR 325

  Fly   323 ESAVGDTDDQQDDHAGGDSSKSNSITSEHSIHSVGVSAASSQSSSSNSIPAAAQNHHHIAAHHHQ 387
            |..:|..        |.:..|.
Human   326 EHRLGQN--------GIEDFKK------------------------------------------- 339

  Fly   388 QAASAAVAAAMHHHHHPHQQPPPSWPSGQQGQPVPPGAVSRNSSRHRNRPPLPNIMHSMNNNVTP 452
                           ||       :.||          :..::.|:...|.:|.:     ::.|.
Human   340 ---------------HP-------FFSG----------IDWDNIRNCEAPYIPEV-----SSPTD 367

  Fly   453 TNSASV-VPAPAPAPVLPPPISVLPHLSAMGHVGGGGTGTGGSGGGSPASGGPLADRIQPVQPRY 516
            |::..| ......:..:|||                 |.|..||...|..|
Human   368 TSNFDVDDDCLKNSETMPPP-----------------THTAFSGHHLPFVG-------------- 401

  Fly   517 LTTPAAQAAVYAASSASSQQAISNAVNDHGPNNFATIRTTSI-----VTKQQKEHMQEEMHEQMS 576
                    ..|.:|...|.::.....  .||        ||:     |.:....::..|.:|:.
Human   402 --------FTYTSSCVLSDRSCLRVT--AGP--------TSLDLDVNVQRTLDNNLATEAYERR- 447

  Fly   577 GYKRMRREHQAHLVKLEEKCKVDMEAHKTALDKEYDTL-----------LHNFTRDLDRL----- 625
             .||:.:|      |||...|: .|:.:|....:|.|:           :.|...::::|
Human   448 -IKRLEQE------KLELSRKL-QESTQTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVT 504

  Fly   626 ETKH-----------QQDVERRAKQTSAAEKKLHKEITLKQENDRKVYDLNRKKEYKANKERWK- 678
            |:.|           :|:::...:|..|.||::.   ||:||.:    |||  ||.....||.|
Human   505 ESSHLEQQLEEANAVRQELDDAFRQIKAYEKQIK---TLQQERE----DLN--KELVQASERLKN 560

  Fly   679 -----------RELSMDESTPKRQRDLTLQSQKDNLKQH--EAQEEQRMLQAQKQYIELEMRKFK 730
                       |:|:|.|.....:|...|.:||..|.:|  :.:||..::..:.:.:..|:|:.:
Human   561 QSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKVESLRQELRRTE 625

  Fly   731 R-------------------KRMIMQHEHEDQQLRDEL-GKKEQQLQQAHAML-LKHHEKTQELE 774
            |                   :::..|.||..:||.:|| |.|::|:..:..:. ::|.::..:|:
Human   626 RAKKELEVHTEALAAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEITKLK 690

  Fly   775 Y-RQQKSVHQLREEQINKQ---HDTELHNQKDYMDRIKKEL---------VRKHAVELRQQPKSL 826
            . .::||:  ..||:::|:   |..|:.|       :||||         :.|..:.|:.:.:..
Human   691 TDLEKKSI--FYEEELSKREGIHANEIKN-------LKKELHDSEGQQLALNKEIMILKDKLEKT 746

  Fly   827 KQKELQIRKQFRETCKTQTKQYKRYKAQVLQTTPKEQQKEVIKQLKE--EKHRKLTLLGEQYEQS 889
            :::....|::|....|   :||:|.|  ||.|   |:.|::..:|.:  ..:..|::..:|.|:.
Human   747 RRESQSEREEFESEFK---QQYEREK--VLLT---EENKKLTSELDKLTTLYENLSIHNQQLEEE 803

  Fly   890 IADMF-QSQSYKLDESQVIE--------------CQRTHEQLEYELEMLTAYQNKNKKQAQEQRD 939
            :.|:. :.:|....|:|:.|              .|....::..|||.|     :|........|
Human   804 VKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEAL-----RNSSLGTRATD 863

  Fly   940 ---RERRELENRVSVRRGLLENKMDAEL-------QQFNQERAERL----RMKHE---------- 980
               :.||..:..:|.|.. |::.:|||:       ::.|:.:|..:    ::|..
Human   864 MPWKMRRFAKLDMSARLE-LQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKNLELLSE 927

  Fly   981 -----KHTKEL------EAFDNESIALGFSTLSLIEVSREAYADEEGSLSGSMISLAHSNSSTSF 1034
                 |.|:||      |..|::...|.|  |:....:.:.:.|...|.|.|:|......|.:..
Human   928 IEQLIKDTEELRSEKGIEHQDSQHSFLAF--LNTPTDALDQFEDSFSSSSSSLIDFLDDRSPSCT 990

  Fly  1035 PA 1036
            ||
Human   991 PA 992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	76/283 (27%)
		S_TKc	27..280	CDD:214567	75/281 (27%)
CDC42BPA	NP_001374479.1	STKc_MRCK_alpha	4..412	CDD:270773	106/537 (20%)
		SbcC	432..>941	CDD:223496	118/549 (21%)
		KELK	530..608	CDD:406277	27/86 (31%)
		C1_MRCKalpha	1062..1121	CDD:410414
		PH_MRCK	1123..1257	CDD:269949
		CNH	1283..1547	CDD:395630

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910