DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tao and map4k6

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	XP_005161478.1	Gene:	map4k6 / 692287	ZFINID:	ZDB-GENE-060512-339	Length:	899	Species:	Danio rerio

Alignment Length:	730	Identity:	191/730 - (26%)
Similarity:	287/730 - (39%)	Gaps:	215/730 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDILKEIRFLRQLNHPN 86
            ||...:|.:..||.|::|.|:.||...|..|.|||.:..   ...:....|..||..::...|.|
Zfish    10 DPLDDYELIHRIGSGTYGDVFKARSIKTSVIAAIKVVKL---DPGDDISSIQNEITMMKDCTHKN 71

  Fly    87 TIEYKGCYLRESTAWLVMEYC-VGSASDIIEVHKKPLHEDEIAAICLGVLSGLSYLHSLGRIHRD 150
            .:.|.|.|||.:..|:.||:| .||..||..| ..||.|.:||.:....|.||.:||..|::|||
Zfish    72 IVAYFGSYLRNNKLWICMEFCGGGSLQDIYHV-TGPLKERQIAYVSRETLQGLHHLHQTGKMHRD 135

  Fly   151 IKAGNILLTDNGVVKLADFGSA----AIKCPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLG 211
            ||..|||||:.|.|||||||.|    |......||:||||||||||.....:|.|:...|:|::|
Zfish   136 IKGANILLTERGDVKLADFGVAAEINASVAKRKSFIGTPYWMAPEVAAVEKKGGYNQLCDIWAVG 200

  Fly   212 ITCIELAERKPPYFNMNAMSALYHIAQN--ESPTL-PKNDWSDAFCSFVELCLKKMPAERPSSAK 273
            ||.|||||.:||.|:::.|.||..::::  :.|.| .||.||..|.||:::.|.|.|.:||::.|
Zfish   201 ITAIELAELQPPMFDLHPMRALMLMSKSSFQPPKLKEKNKWSTEFHSFIKMALTKNPRKRPTAEK 265

  Fly   274 LLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKILMVD--TCETESAVGD-------- 328
            :|.||:|.:..:..:::||          ||.:|...:::...:|  ..||.|.:.|
Zfish   266 ILQHAFVMQLLTRNLVIEL----------LDTVNNPDLQQTQTMDESDLETCSVLPDKIHSLAKL 320

  Fly   329 -----TDDQQDDH------------------AGGDSSKSNSITSEHSI----------HSVGVSA 360
                 ..:||.||                  |..|.|..::.....|:          .|:.:..
Zfish   321 PVQRTLSEQQFDHVKFGLPMRKETDPCPVLEAYDDWSSISADKDSPSLLECVEEALMERSLTIKR 385

  Fly   361 ASSQSSSSN------SIPAAAQNHHHIAAHHHQQAASAAVAAAMHHHHHPHQQPPPSWPSGQQGQ 419
            .||...|.|      ::...|.:....|..|.::.|..                |.|.||
Zfish   386 VSSVEHSPNEEDKYGTVKRMASSPQSTALCHQEKKAPT----------------PSSIPS----- 429

  Fly   420 PVPPGAVSRNSSRHRNRPPLPNI--------------MHSMNNNVTPTNSASVVPAPA------- 463
            |:...:..:|.|.:.|    |::              |..:.|:...|:|:.:..:.:
Zfish   430 PIIGSSSLKNPSPNTN----PSLLSESALLIGSTLSHMSLITNSCLFTDSSFLSHSTSLGSLCLT 490

  Fly   464 PAPVLPPPISVLPHLSAMGHVGGGGTGTGGSGGGSPASGGPLADRIQPVQPRYLTTPAAQAAVYA 528
            |...|.|..||.|        ..|||.|..:...|            ||.|.:.|....|
Zfish   491 PTEGLIPESSVAP--------DPGGTRTYSTPPDS------------PVSPEWSTLRRKQ----- 530

  Fly   529 ASSASSQQAISNAVNDHGPN-------------NFATIRT----TSIVTKQQKEHMQ-------- 568
                ...:|:   ||...|.             |...::|    |.::.|.:.:::.
Zfish   531 ----DDSKAV---VNGLPPTPQVHMGACFSKVFNGCPLKTHCAVTWVLPKTRDQYLMLGAEEGVY 588

  Fly   569 ----EEMHE----------------------QMSG---------------YKRMRREHQAHLVKL 592
                .|:||                      .:||               |:|..:..|.||...
Zfish   589 TLNLNELHEDTMEKLLPQRCIWLYVMNNVLMSISGKSSQLTSHSLPALFEYRRNMQRRQGHLAIN 653

  Fly   593 EEKCKVDMEAHKTAL 607
            ..:....:.|.|.|:
Zfish   654 AHRLSTKINARKYAM 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	112/264 (42%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	111/260 (43%)
map4k6	XP_005161478.1	STKc_MAP4K3_like	14..272	CDD:270788	111/261 (43%)
		S_TKc	15..272	CDD:214567	111/260 (43%)
		CNH	565..879	CDD:295303	15/104 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910