DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tao and Plk3

DIOPT Version :9

Sequence 1:NP_001188672.1 Gene:Tao / 32948 FlyBaseID:FBgn0031030 Length:1039 Species:Drosophila melanogaster
Sequence 2:NP_071523.1 Gene:Plk3 / 58936 RGDID:62039 Length:647 Species:Rattus norvegicus


Alignment Length:613 Identity:146/613 - (23%)
Similarity:226/613 - (36%) Gaps:124/613 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 PSARPGSLKDPEIADLFNK-HDPE--KIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGK 63
            |.:.||.|..|:..|.... .||.  :.:...|.:|.|.|...|.|....|....|:|.:..:..
  Rat    34 PRSEPGVLAGPQTPDASRLITDPRSGRTYIKGRLLGKGGFARCYEATDTETSIAYAVKVIPQSRV 98

  Fly    64 QSQEKWQDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIA 128
            ....:.:.|:.||...|.|.|.:.:.:...:......::.:|.|...:...|...:..|.|.|:.
  Rat    99 AKPHQREKIINEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVR 163

  Fly   129 AICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCP----ANSFVGTPYWMA 189
            .....:||||.|||..|.:|||:|.||..:|||..:|:.|||.||...|    ..:..|||.::|
  Rat   164 YYLRQILSGLKYLHQRGILHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQRKKTICGTPNYVA 228

  Fly   190 PEVILAMDEGQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSDAFC 254
            |||:|....|.   :.||||||.....|....|| |....:...|...:....|||.: .|....
  Rat   229 PEVLLRQGHGP---EADVWSLGCVMYTLLCGSPP-FETADLKETYRCIKQVHYTLPAS-LSLPAR 288

  Fly   255 SFVELCLKKMPAERPSSAKLLTHAYVTR-------PRSDTVLL----------ELIAR-TKSAV- 300
            ..:...|:..|.:|||..::|.|.:.|:       |.|..|.:          .|.|: |||.. 
  Rat   289 QLLAAILRASPRDRPSIEQILRHDFFTKGYTPDRLPVSSCVTVPDLTPPNPARSLFAKVTKSLFG 353

  Fly   301 -RELDNLNY-RKMKKILMVDTCETESAVGDTDDQQD-------------DHAGGDSSKSNSITSE 350
             |:..|.|: .:...:..:.:....:::|..|.:.:             :.|..|||...::.|.
  Rat   354 RRKSKNKNHSEEQDNVSCLVSGLMRTSIGHPDVRPEAPAASALAPVSLVETAAEDSSPRGTLASS 418

  Fly   351 H-------SIHSVGVSAASSQSSSSNSIPAAAQNHHHIAAHHHQQAASAAVAAAMHHHHHPHQQP 408
            .       ::.:|..||..:..:....:|.|.||...:|                        ||
  Rat   419 GDGFEEGLTVTTVVESALCALRNCVAFMPPAEQNPAPLA------------------------QP 459

  Fly   409 PP-SWPS-----------GQQ--GQPVPPGAVSRNSSRH----RNRPPLPNIMHSMNNNVTPTNS 455
            .| .|.|           |.|  .:.|   ||..|...|    .||       .:::.|.|.|..
  Rat   460 EPLVWVSKWVDYSNKFGFGYQLSSRRV---AVLFNDGTHMALSANR-------KTVHYNPTSTKH 514

  Fly   456 ASVVPAPAPAPVLPPPISVLPHLSAM--GHVGGGGTGTGGSGGGSPASGGPLADRIQ-PVQPRYL 517
            .|......|. .|.|.:.:|.:.::.  .|:..||             ..|..:.:: |..|..|
  Rat   515 FSFSVGSVPR-ALQPQLGILRYFASYMEQHLMKGG-------------DLPSVEEVEVPAPPLLL 565

  Fly   518 TTPAAQAAVYAASSASSQQAISNAVNDH 545
            .......|:....|..:.|.  |...||
  Rat   566 QWVKTDQALLMLFSDGTVQV--NFYGDH 591

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TaoNP_001188672.1 STKc_TAO 25..282 CDD:270784 76/260 (29%)
S_TKc 27..280 CDD:214567 76/256 (30%)
Plk3NP_071523.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..56 6/21 (29%)
STKc_PLK3 60..314 CDD:271091 76/258 (29%)
S_TKc 62..314 CDD:214567 76/256 (30%)
POLO_box_1 461..549 CDD:240561 23/111 (21%)
POLO_box_2 562..629 CDD:240560 8/32 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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