DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tao and TAOK1

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_065842.1	Gene:	TAOK1 / 57551	HGNCID:	29259	Length:	1001	Species:	Homo sapiens

Alignment Length:	1025	Identity:	503/1025 - (49%)
Similarity:	659/1025 - (64%)	Gaps:	121/1025 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPSA-RPGSLKDPEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQ 64
            |||. |.|||||||||:||.|.||||:|.||||||||||||||:||...|.|:||||||||:|||
Human     1 MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQ 65

  Fly    65 SQEKWQDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAA 129
            |.||||||:||::||:::.|||:||||||||||.|||||||||:|||||::|||||||.|.||||
Human    66 STEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAA 130

  Fly   130 ICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPANSFVGTPYWMAPEVIL 194
            |..|.|.||:||||...|||||||||||||:.|.|||||||||::..||||||||||||||||||
Human   131 ITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVIL 195

  Fly   195 AMDEGQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSDAFCSFVEL 259
            |||||||||||||||||||||||||||||.||||||||||||||||||||..|:|||.|.:||:.
Human   196 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDS 260

  Fly   260 CLKKMPAERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKILMVDTCETES 324
            ||:|:|.:||:|.:||.|.:|.|.|.:|||::||.|||.||||||||.||||||:|..:.....:
Human   261 CLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPA 325

  Fly   325 AVGDTDDQQDDHAGGDSSKSNSITSEHSIHSVGVSAASSQSSSSNSIPAAAQNHHHI---AAHHH 386
            .....::::.||..|.:...||:.|..||.|:.:| |||||||.||:|..:.:...:   ...|.
Human   326 VEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSIS-ASSQSSSVNSLPDVSDDKSELDMMEGDHT 389

  Fly   387 QQAASAAVAAAMHHHHHPHQQPPPSWPSGQQGQPVPPGAVSRNSSRHRNRPPLPNIMHSMNNNVT 451
            ..:.|:.:.......::..:..|.:    :...|..|..|||:.|.:|||
Human   390 VMSNSSVIHLKPEEENYREEGDPRT----RASDPQSPPQVSRHKSHYRNR--------------- 435

  Fly   452 PTNSASVVPAPAPAPVLPPPISVLPHLSAMGHVGGGGTGTGGSGGGSPASGGPLADRIQPVQPRY 516

Human   436 ----------------------------------------------------------------- 435

  Fly   517 LTTPAAQAAVYAASSASSQQAISNAVNDHGPNNFATIRTTSIVTKQQKEHMQE-EMHEQMSGYKR 580
                                           .:||||||.|:||:|.:||.|: |:.||||||||
Human   436 -------------------------------EHFATIRTASLVTRQMQEHEQDSELREQMSGYKR 469

  Fly   581 MRREHQAHLVKLEEKCKVDMEAHKTALDKEYDTLLHNFTRDLDRLETKHQQDVERRAKQTSAAEK 645
            |||:||..|:.||.|.|.:|:.|:..|||:.:|..:||..::::|..|||..:|:.||..|..||
Human   470 MRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEK 534

  Fly   646 KLHKEITLKQENDRKVYDLNRKKEYKANKERWKRELSMDESTPKRQRDLTLQSQKDNLKQHEAQE 710
            |..:.|..:|:.:...:..::|:|||..||:.|.||:.::||||:::...|..||:|::..:|:|
Human   535 KFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEE 599

  Fly   711 EQRMLQAQKQYIELEMRKFKRKRMIMQHEHEDQQLRDELGKKEQQLQQAHAMLLKHHEKTQELEY 775
            |..:|:.|:||:|||.|:|||:.::.:|..|...:|:||.|::.|....|||||:.||..||||:
Human   600 EANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEF 664

  Fly   776 RQQKSVHQLREEQINKQHDTELHNQKDYMDRIKKELVRKHAVELRQQPKSLKQKELQIRKQFRET 840
            |...::.::|.|.|..||.|||.||.:|..|.::||.|||.:|:||||||||.|||||:|||::|
Human   665 RHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDT 729

  Fly   841 CKTQTKQYKRYKAQVLQTTPKEQQKEVIKQLKEEKHRKLTLLGEQYEQSIADMFQSQSYKLDESQ 905
            ||.||:|||..:..:|:||||.:.|.|:|:||||:.|||.:|.|||:.||.:|..:|:.:|||:|
Human   730 CKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQ 794

  Fly   906 VIECQRTHEQLEYELEMLTAYQNKNKKQAQEQRDRERRELENRVSVRRGLLENKMDAELQQFNQE 970
            ..|||....||:.|||:|.|||:|.|.||:.|.|||.||||.|||:||.|||.|::.|:.....|
Human   795 EAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNE 859

  Fly   971 RAERLRMKHEKHTKELEAFDNESIALGFSTLSLIEVSREAYADEEGSLSG 1020
            |.||:|...|:..:|:||||:||:.||||.:.|..:|.||::......||
Human   860 RTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASG 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	198/256 (77%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	196/252 (78%)
TAOK1	NP_065842.1	STKc_TAO1	2..318	CDD:270805	241/315 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..433		29/113 (26%)
		SbcC	<442..>877	CDD:223496	209/434 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	567..587		8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	456	1.000	Domainoid score	I498
eggNOG	1	0.900	-	-		E1_KOG0577
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H27041
Inparanoid	1	1.050	991	1.000	Inparanoid score	I308
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48447
OrthoDB	1	1.010	-	-		D277938at33208
OrthoFinder	1	1.000	-	-		FOG0001318
OrthoInspector	1	1.000	-	-		otm40953
orthoMCL	1	0.900	-	-		OOG6_102967
Panther	1	1.100	-	-	LDO	PTHR48015
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2826
SonicParanoid	1	1.000	-	-		X816
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870