DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tao and PAK6

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_001263646.1	Gene:	PAK6 / 56924	HGNCID:	16061	Length:	681	Species:	Homo sapiens

Alignment Length:	306	Identity:	112/306 - (36%)
Similarity:	158/306 - (51%)	Gaps:	33/306 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDILKEIRFLRQLNHPN 86
            ||..:.:...:||.||.|.|..||...:...||:|.|....:|.:|.   :..|:..:|...|.|
Human   402 DPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRREL---LFNEVVIMRDYQHFN 463

  Fly    87 TIEYKGCYLRESTAWLVMEYCVGSA-SDIIEVHKKPLHEDEIAAICLGVLSGLSYLHSLGRIHRD 150
            .:|....||.....|::||:..|.| :||  |.:..|:|::||.:|..||..|:|||:.|.||||
Human   464 VVEMYKSYLVGEELWVLMEFLQGGALTDI--VSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRD 526

  Fly   151 IKAGNILLTDNGVVKLADFGSAA---IKCP-ANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLG 211
            ||:.:||||.:|.|||:|||..|   ...| ..|.||||||||||||   ....|..:||:||||
Human   527 IKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI---SRSLYATEVDIWSLG 588

  Fly   212 ITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDW--SDAFCSFVELCLKKMPAERPSSAKL 274
            |..||:.:.:||||:.:.:.|:..:..:..|.| ||..  |.....|:|..|.:.|.||.::.:|
Human   589 IMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKL-KNSHKVSPVLRDFLERMLVRDPQERATAQEL 652

  Fly   275 LTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKILMVDTC 320
            |.|.::.:......|:.||..            |||     ...||
Human   653 LDHPFLLQTGLPECLVPLIQL------------YRK-----QTSTC 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	102/263 (39%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	102/259 (39%)
PAK6	NP_001263646.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		PBD	11..67	CDD:307091
		Linker	26..406		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..169
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..256
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	268..355
		STKc_PAK6	385..681	CDD:270821	110/304 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910