DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tao and si:zfos-2326c3.2

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	XP_009306038.1	Gene:	si:zfos-2326c3.2 / 561669	ZFINID:	ZDB-GENE-091113-25	Length:	1165	Species:	Danio rerio

Alignment Length:	796	Identity:	219/796 - (27%)
Similarity:	310/796 - (38%)	Gaps:	229/796 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDILKEIRFLR 80
            ||.:..||..|||.:..:|:|::|.||..|...|.::.|||.|..|    :::..:|..||..|:
Zfish    14 DLASLRDPAGIFELIEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVT----EDEEDEIKLEINMLK 74

  Fly    81 -QLNHPNTIEYKGCYLRESTA------WLVMEYC-VGSASDIIEVHK-KPLHEDEIAAICLGVLS 136
             ..:|.|...|.|.::::|.|      ||||||| .||.:|:::..| ..|.||.||.:|..||.
Zfish    75 THSHHRNIATYYGAFVKKSPAGQDDQLWLVMEYCGAGSVTDLLKKTKGNCLKEDWIAYVCREVLR 139

  Fly   137 GLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFG-SAAIKCP---ANSFVGTPYWMAPEVILAMD 197
            ||.:|||...||||||..|:|||:|..:||.||| ||.:...   .|:|:||||||||||| |.|
Zfish   140 GLLHLHSHHVIHRDIKGQNVLLTENAEIKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVI-ACD 203

  Fly   198 E---GQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSDAFCSFVEL 259
            |   ..||.:.||||||||.:|:||..||..:|:.|.||:.|.:|..|.|....||..|.:||:.
Zfish   204 ENPDSTYDYRSDVWSLGITALEMAEGVPPLCDMHPMRALFLIPRNPPPKLKSKKWSKKFQTFVDS 268

  Fly   260 CLKKMPAERPSSAKLLTHAYV-TRPRSDTVLLEL---IARTKSAVRELDNLNYRKMKKILMVDTC 320
            ||.|....|||:..||.|::: ..|....|.:.|   :.||:...:|.|...|.
Zfish   269 CLVKNYLHRPSTETLLRHSFIKDLPNERQVRITLKDHLDRTRKRRQEKDGKEYE----------- 322

  Fly   321 ETESAVGDTDDQQDDHAGGDSS-------------------KSNSIT------------------ 348
              .|...|.||..::..|..||                   ::||.|
Zfish   323 --YSGSEDEDDGINEEEGEPSSIVNLPGESMLRREFLRLQQETNSQTQLIQQVHNQDNYKKQLLA 385

  Fly   349 -------------------SEHSIHSVGVS---------------------------------AA 361
                               .|..:|..||.                                 ..
Zfish   386 DRQKRIQQQQEERRRFEDHQERLLHETGVQWPELQEMLWQEETDLTEKSKRNHKKQPKDSEHHRT 450

  Fly   362 SSQSSSSNSIPAAAQNHHH--------------IAAHHHQQAASAAV--------AAAMHHH--- 401
            ..:|:|||.....||....              :..|.|||.:|.|.        ..::..|
Zfish   451 DVESASSNLFDEQAQGRKAQRTLPRDQSQLLFLLHDHTHQQKSSRATPHDGLAGKLESLETHLVN 515

  Fly   402 ------HHPHQQPPPSWPSGQQGQPVPPGAVSRNSSRHRNRPPLPNIMHSMNNNVTPTNSASVVP 460
                  ..||.|  ....||....|..| |:.|...:       ||:....:..:..::|.|.|.
Zfish   516 LNNLAVRIPHVQ--SRLGSGSNSSPCTP-ALQRAVKQ-------PNMNVCSSQEIHHSSSMSDVN 570

  Fly   461 APAPAPVL----------PPPI---SVLPHLSAMGHVGGGGTGT-------------GGSGGGSP 499
            ||. :|.|          ||.|   :.......|||...|.:|.             ..|...|.
Zfish   571 APL-SPTLDDVFFTPDDQPPKIPERTTSKFKDVMGHHRYGSSGDRQSAMDNAVKMSFSNSSTSSS 634

  Fly   500 ASGGPLADRIQPVQP-RYLTTPAA-----------------QAAVYAASSASSQQAISNAVNDHG 546
            .||..:.|  .|..| |...:|.|                 :.|.|::||....:.: .:.:.:|
Zfish   635 QSGYCVLD--NPAHPNRNSQSPGASPHNQGLGTKSQFSPLMKLAEYSSSSDEDDEKM-RSPSSNG 696

  Fly   547 PNNFATIRTTSIV------TKQQKEHMQEEMHEQMSGYKR---MRREHQAHLVKLEEKCKV-DME 601
            ...|:..:|..|:      .|||::...:..|   :.|:|   .:.....||..|..|... ::.
Zfish   697 RPVFSRGQTNEIILQPHLNVKQQQQSAAKPTH---NVYQRPCGSQSSDNYHLPDLLHKSPTHELS 758

  Fly   602 AHKTALDKEYDTLLHN 617
            .|:|......|.||:|
Zfish   759 YHQTPTQSSRDKLLNN 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	120/273 (44%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	119/268 (44%)
si:zfos-2326c3.2	XP_009306038.1	PKc_like	9..289	CDD:304357	124/279 (44%)
		S_TKc	25..289	CDD:214567	119/268 (44%)
		CNH	847..1143	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910