DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tao and taok2a

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	XP_009297645.1	Gene:	taok2a / 556172	ZFINID:	ZDB-GENE-030131-9416	Length:	1141	Species:	Danio rerio

Alignment Length:	1042	Identity:	492/1042 - (47%)
Similarity:	656/1042 - (62%)	Gaps:	131/1042 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MP-SARPGSLKDPEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQ 64
            || |.|.|:|||.|:::||.:.||||:|.||||||||||||||:|....:.|:|||||||::|||
Zfish     1 MPASVRTGTLKDSEVSELFYRDDPEKLFTDLREIGHGSFGAVYFAHDVRSNEVVAIKKMSFSGKQ 65

  Fly    65 SQEKWQDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAA 129
            |.||||||:||::||::|.||||||||||||||.|||||||||:|||||::|||||||.|.||||
Zfish    66 SNEKWQDIIKEVKFLQKLRHPNTIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEMEIAA 130

  Fly   130 ICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPANSFVGTPYWMAPEVIL 194
            |..|.|.||:||||...||||:||||||||:.|.|||.|||||:|..||||||||||||||||||
Zfish   131 ITHGALQGLAYLHSHNMIHRDVKAGNILLTEPGQVKLGDFGSASIVSPANSFVGTPYWMAPEVIL 195

  Fly   195 AMDEGQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSDAFCSFVEL 259
            |||||||||||||||||||.|||||||||.||||||||||||||||||.|..|.|||.|.:||:.
Zfish   196 AMDEGQYDGKVDVWSLGITSIELAERKPPLFNMNAMSALYHIAQNESPVLASNHWSDYFRNFVDS 260

  Fly   260 CLKKMPAERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKILMVDTCETES 324
            ||:|:|.:||:|..||.|.::.|.|..:|:::||.|||.||||||||.||||||||..:|.....
Zfish   261 CLQKIPQDRPTSDVLLNHHFLCRERPHSVVMDLITRTKDAVRELDNLQYRKMKKILFQETHNGPV 325

  Fly   325 AVGDTDDQQDDHAGGDSSKSNSITSEHSIHSVGVSAASSQSSSSNSIPAAAQNHHHIAAHHHQQA 389
            ..|..::::.:.....:...||:.|..|:.|:.:| |||||||.||:...:.:
Zfish   326 QEGGEEEEEGEQYLLQTGTVNSMESSQSVPSMSIS-ASSQSSSVNSLADGSDD------------ 377

  Fly   390 ASAAVAAAMHHHHHPHQQPPPSWPSGQQGQPVPPGAVSRNSSRHRNRPPLPNIMHSMNNNVTPTN 454
              :|..|.|                 |:|:.                              |.|:
Zfish   378 --SAEMAMM-----------------QEGEQ------------------------------TVTS 393

  Fly   455 SASVVPAPAPAPVLPPPISVLPHLSAMGHVGGGGTGTGGSGGGSPASGGPLADRIQPVQPRYLTT 519
            ::|::..|                ||..::                ...|....::..||
Zfish   394 NSSIIHRP----------------SARDNI----------------YDDPYQPEMESQQP----- 421

  Fly   520 PAAQAAVYAASSASSQQAISNAVNDHGPNNFATIRTTSIVTKQQKEHMQ-EEMHEQMSGYKRMRR 583
                     ||||:.::...|  .||    ||||||.|:||:|.:||.| ..:.|||||||||||
Zfish   422 ---------ASSAARRRIHRN--RDH----FATIRTASVVTRQIQEHEQGSALREQMSGYKRMRR 471

  Fly   584 EHQAHLVKLEEKCKVDMEAHKTALDKEYDTLLHNFTRDLDRLETKHQQDVERRAKQTSAAEKKLH 648
            :||..|:.||.|.|.:|:.|:..||||.:|..:||..:.|:|..||...:|:..|.....|||..
Zfish   472 QHQKQLLALENKLKSEMDEHQLRLDKELETQRNNFGSEADKLGKKHLAILEKEIKGAQTEEKKFQ 536

  Fly   649 KEITLKQENDRKVYDLNRKKEYKANKERWKRELSMDESTPKRQRDLTLQSQKDNLKQHEAQEEQR 713
            :.|..:|:.:......|:|::|:..|::.|.|||.::|||||::...|..||:.|:|.:|:||..
Zfish   537 QHILNQQKKELNSLLDNQKRQYRQRKDQLKEELSENQSTPKREKQEWLVRQKECLQQIQAEEEAS 601

  Fly   714 MLQAQKQYIELEMRKFKRKRMIMQHEHEDQQLRDELGKKEQQLQQAHAMLLKHHEKTQELEYRQQ 778
            :|:.|:||.||:.|::|||.::.:|..|...||::|.|::.|.....||||:|||.|||||:||.
Zfish   602 LLRRQRQYYELQCRQYKRKMLLARHNLEQDLLREDLNKRQTQKDLECAMLLRHHESTQELEFRQL 666

  Fly   779 KSVHQLREEQINKQHDTELHNQKDYMDRIKKELVRKHAVELRQQPKSLKQKELQIRKQFRETCKT 843
            ..|.:.|.:.|..||.:||.||.:|..|.::||.:|||||:||||||||.|||||::||::|||.
Zfish   667 ALVQRTRADLIRTQHQSELANQMEYNKRREQELRQKHAVEVRQQPKSLKTKELQIKRQFQDTCKI 731

  Fly   844 QTKQYKRYKAQVLQTTPKEQQKEVIKQLKEEKHRKLTLLGEQYEQSIADMFQSQS---YKLDESQ 905
            ||:|||..:..:|:||||.:.|.|:|:||||:.|||.:|.|||:.||.||..:|:   .:|||:|
Zfish   732 QTRQYKALRNHLLETTPKSEHKTVLKRLKEEQTRKLAILAEQYDHSIKDMLSTQAVSKLRLDETQ 796

  Fly   906 VIECQRTHEQLEYELEMLTAYQNKNKKQAQEQRDRERRELENRVSVRRGLLENKMDAELQQFNQE 970
            ..|.:....||:.|||:|.|||:|.|.....|.:||.::||.|||:||.|||.:::.|:.....|
Zfish   797 EDEYRALRMQLQQELELLNAYQSKIKMHTDTQHEREVKDLEQRVSIRRALLEQRIEEEMLSLQNE 861

  Fly   971 RAERLRMKHEKHTKELEAFDNESIALGFSTLSLIEVSREAYADEEGSLSGSMISLAHSNSSTSFP 1035
            |:||:|...|:..:|:|:||:||:.||||.::|..:..|||            :..:||..:|.|
Zfish   862 RSERIRALLEQQAREIESFDSESMRLGFSNMALSGIPAEAY------------NQGYSNPPSSGP 914

  Fly  1036 AG 1037
            .|
Zfish   915 GG 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	193/256 (75%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	192/252 (76%)
taok2a	XP_009297645.1	PKc_like	6..318	CDD:304357	228/311 (73%)
taok2a	XP_009297645.1	S_TKc	28..281	CDD:214567	192/252 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	525	1.000	Domainoid score	I276
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	970	1.000	Inparanoid score	I302
OMA	1	1.010	-	-		QHG48447
OrthoDB	1	1.010	-	-		D277938at33208
OrthoFinder	1	1.000	-	-		FOG0001318
OrthoInspector	1	1.000	-	-		otm24956
orthoMCL	1	0.900	-	-		OOG6_102967
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X816
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980