DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tao and AgaP_AGAP003202

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	XP_001237504.2	Gene:	AgaP_AGAP003202 / 4577219	VectorBaseID:	AGAP003202	Length:	983	Species:	Anopheles gambiae

Alignment Length:	1070	Identity:	717/1070 - (67%)
Similarity:	813/1070 - (75%)	Gaps:	123/1070 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RPGSLKDPEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKW 69
            |||||||||||:||||||||||||||||||||||||||||:||||.||||||||||.||||.|||
Mosquito     2 RPGSLKDPEIAELFNKHDPEKIFEDLREIGHGSFGAVYYAKCNLTPEIVAIKKMSYMGKQSMEKW 66

  Fly    70 QDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAAICLGV 134
            ||||||||||||||||||||||||||.|:|||||||||||||||||||||:||.||||:|||.||
Mosquito    67 QDILKEIRFLRQLNHPNTIEYKGCYLHENTAWLVMEYCVGSASDIIEVHKRPLKEDEISAICDGV 131

  Fly   135 LSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPANSFVGTPYWMAPEVILAMDEG 199
            |.|||||||||||||||||||||||:.|:||||||||||||||||||||||||||||||||||||
Mosquito   132 LRGLSYLHSLGRIHRDIKAGNILLTEQGIVKLADFGSAAIKCPANSFVGTPYWMAPEVILAMDEG 196

  Fly   200 QYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSDAFCSFVELCLKKM 264
            ||||||||||||||||||||||||||||||||||||||||::|:|...:|||.|.:||:.||||.
Mosquito   197 QYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNDAPSLQAQEWSDMFRNFVDFCLKKS 261

  Fly   265 PAERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKILMVDTCETESAVGDT 329
            |.:||:|.:||.|..|||.||..||::||||||:|||||||||||||||||||| |||||.:||.
Mosquito   262 PIDRPTSTQLLKHTLVTRARSPNVLIDLIARTKAAVRELDNLNYRKMKKILMVD-CETESNIGDA 325

  Fly   330 DDQQDDHAGGDSSKSNSITSEHSIHSVGVSAASSQSSSSNSIPAAAQNHHHIAAHHHQQAASAAV 394
            :|..|:..|||||||||||||||:.||.                          ...||
Mosquito   326 EDTPDEQIGGDSSKSNSITSEHSLPSVD--------------------------QQQQQ------ 358

  Fly   395 AAAMHHHHHPHQQPPPSWPSGQQGQPVPPGAVSRNSSRHRNRPPLPNIMHSMNNNVTPTNSASVV 459
              .:|..|                 .|..| :.||||  |:||  .|.|.:|:||....|:..
Mosquito   359 --QLHQQH-----------------GVGSG-LMRNSS--RSRP--ANAMSAMHNNSAGGNARD-- 397

  Fly   460 PAPAPAPVLPPPISVLPHLSAMGHVGGGGTG------TGGSGGGSPASGGPLADRIQPVQPRYLT 518
                         |:|.::...|..||.|:|      :|.:||||...|
Mosquito   398 -------------SMLSNVMMAGISGGSGSGSGMMMASGMAGGGSVGMG---------------- 433

  Fly   519 TPAAQAAVYAASSASS-----------------------------QQAISNAVNDHGPNNFATIR 554
            |...|:|..|...|:.                             .|..:|||.:||.|||||||
Mosquito   434 TSGMQSAGAAGGQANMGASMGYHHHNSSSPVVSAHHHPQHNHNHVSQVAANAVAEHGANNFATIR 498

  Fly   555 TTSIVTKQQKEHMQEEMHEQMSGYKRMRREHQAHLVKLEEKCKVDMEAHKTALDKEYDTLLHNFT 619
            |||||||||||||||||||||||||||||||||.||||||||||:||.||:|||||||.||||||
Mosquito   499 TTSIVTKQQKEHMQEEMHEQMSGYKRMRREHQAALVKLEEKCKVEMEQHKSALDKEYDLLLHNFT 563

  Fly   620 RDLDRLETKHQQDVERRAKQTSAAEKKLHKEITLKQENDRKVYDLNRKKEYKANKERWKRELSMD 684
            |:||:...||||::.||.||...|||||||||..:||.|||.::::|||||||||||||||||||
Mosquito   564 RELDKQSAKHQQEIVRRVKQNDTAEKKLHKEIATRQEGDRKAFEIHRKKEYKANKERWKRELSMD 628

  Fly   685 ESTPKRQRDLTLQSQKDNLKQHEAQEEQRMLQAQKQYIELEMRKFKRKRMIMQHEHEDQQLRDEL 749
            ::|||||||.|||:||||||..|||||||:|:.||.|||||||||:||:|.:.|:.|||.|||||
Mosquito   629 DTTPKRQRDATLQTQKDNLKLAEAQEEQRLLRVQKTYIELEMRKFRRKKMGLLHDLEDQLLRDEL 693

  Fly   750 GKKEQQLQQAHAMLLKHHEKTQELEYRQQKSVHQLREEQINKQHDTELHNQKDYMDRIKKELVRK 814
            .||:|||:||||||:|||||||:||||||||||.||||||:|||::||.||.:||||.::||:|:
Mosquito   694 SKKQQQLEQAHAMLIKHHEKTQDLEYRQQKSVHALREEQISKQHESELRNQNEYMDRAERELLRR 758

  Fly   815 HAVELRQQPKSLKQKELQIRKQFRETCKTQTKQYKRYKAQVLQTTPKEQQKEVIKQLKEEKHRKL 879
            ||:||:|||||||||||||||||||||||||.|||..|.|:|||||||.||.||||||||:||||
Mosquito   759 HALELKQQPKSLKQKELQIRKQFRETCKTQTIQYKALKRQILQTTPKEDQKAVIKQLKEEQHRKL 823

  Fly   880 TLLGEQYEQSIADMFQSQSYKLDESQVIECQRTHEQLEYELEMLTAYQNKNKKQAQEQRDRERRE 944
            ||||:|||||||||.|.||.:|||||.:||.:..::|:|||::|||||:||:.|||.||||||:|
Mosquito   824 TLLGDQYEQSIADMLQKQSLRLDESQEVECHQLKDRLQYELDILTAYQSKNRMQAQAQRDRERKE 888

  Fly   945 LENRVSVRRGLLENKMDAELQQFNQERAERLRMKHEKHTKELEAFDNESIALGFSTLSLIEVSRE 1009
            ||:||||||.|||:||:.||||||||||||:|...|||.|:|||||.||..:|||.|:|.|.|:|
Mosquito   889 LEDRVSVRRALLESKMETELQQFNQERAERIRQLKEKHDKQLEAFDEESARMGFSALALAEASKE 953

  Fly  1010 AYADEEGSLSGSMISLAHSNSSTSFPAGSL 1039
            .|.|||.||||||:||||||||||||||||
Mosquito   954 TYPDEEASLSGSMLSLAHSNSSTSFPAGSL 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	221/256 (86%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	218/252 (87%)
AgaP_AGAP003202	XP_001237504.2	STKc_TAO	22..279	CDD:270784	221/256 (86%)
AgaP_AGAP003202	XP_001237504.2	S_TKc	24..274	CDD:214567	217/249 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	871	1.000	Domainoid score	I215
eggNOG	1	0.900	-	-		E1_KOG0577
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H27041
Inparanoid	1	1.050	1368	1.000	Inparanoid score	I437
OMA	1	1.010	-	-		QHG48447
OrthoDB	1	1.010	-	-		D16111at33392
OrthoFinder	1	1.000	-	-		FOG0001318
OrthoInspector	1	1.000	-	-		otm50122
Panther	1	1.100	-	-	LDO	PTHR48015
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X816
TreeFam	1	0.960	-	-
	13	12.940