DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tao and Taok2

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_001157247.1	Gene:	Taok2 / 381921	MGIID:	1915919	Length:	1240	Species:	Mus musculus

Alignment Length:	1000	Identity:	422/1000 - (42%)
Similarity:	568/1000 - (56%)	Gaps:	149/1000 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPS-ARPGSLKDPEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQ 64
            ||: .|.||||||::|:||.|.||||:|.||||||||||||||:||.....|:||||||||:|||
Mouse     1 MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQ 65

  Fly    65 SQEKWQDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAA 129
            |.||||||:||:|||::|.|||||:|:||||||.|||||||||:|||||::|||||||.|.||||
Mouse    66 SNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAA 130

  Fly   130 ICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPANSFVGTPYWMAPEVIL 194
            :..|.|.||:||||...||||:|||||||::.|:|||.|||||:|..||||||||||||||||||
Mouse   131 VTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVIL 195

  Fly   195 AMDEGQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSDAFCSFVEL 259
            |||||||||||||||||||||||||||||.||||||||||||||||||.|....||:.|.:||:.
Mouse   196 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDS 260

  Fly   260 CLKKMPAERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKILMVDTCETES 324
            ||:|:|.:||:|..||.|.:|.|.|..||:::||.|||.||||||||.||||||||..:......
Mouse   261 CLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPG 325

  Fly   325 AVGDTDDQ-----QD----DHAGGDSSKSNSITSEHSIHSVGVSAASSQSSSSNSIPAAAQNHHH 380
            |....:::     |:    .|..|..:   |:.|.||:.|:.:| |||||||.||:..|:.|...
Mouse   326 AEAPEEEELTPCSQEAEPYTHRAGTLT---SLESSHSVPSMSIS-ASSQSSSVNSLADASDNEEE 386

  Fly   381 IAAHHHQQAASAAVAAAMHHHHHPHQQPPPSWPSG--QQGQPVPPGAVSRNSSRHRNRPPLPNIM 443
            ......::             ....::.|.|....  |:|:..   ..|.:|..||    ||...
Mouse   387 EEEEEEEE-------------EEEEEEGPESREMAMMQEGEHT---VTSHSSIIHR----LPGSD 431

  Fly   444 HSMNNNVTPTNSASVVPAPAPAPVLPPPISVLPHLSAMGHVGGGGTGTGGSGGGSPASGGPLADR 508
            :..::...|    .:.|.|...|..||                  |.|..|
Mouse   432 NLYDDPYQP----EMTPGPLQPPAAPP------------------TSTSSS-------------- 460

  Fly   509 IQPVQPRYLTTPAAQAAVYAASSASSQQAISNAVNDHGPNNFATIRTTSIVTKQQKEHMQEE-MH 572
                         |:...|..:            .||    ||||||.|:|::|.:||.|:. :.
Mouse   461 -------------ARRRAYCRN------------RDH----FATIRTASLVSRQIQEHEQDSALR 496

  Fly   573 EQMSGYKRMRREHQAHLVKLEEKCKVDMEAHKTALDKEYDTLLHNFTRDLDRLETKHQQDVERRA 637
            ||:||||||||:||..|:.||.:.:.:.|.|...|.:|.:.....|..:.::|..:||...|:.|
Mouse   497 EQLSGYKRMRRQHQKQLLALESRLRGEREEHSGRLQRELEAQRAGFGTEAEKLARRHQAIGEKEA 561

  Fly   638 KQTSAAEKKLHKEITLKQENDRKVYDLNRKKEYKANKERWKRELSMDESTPKRQRDLTLQSQKDN 702
            :...|.|:|..:.|..:|:.:.......:|:.||..||:.|.||..:.|||||::...|..||:.
Mouse   562 RAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQ 626

  Fly   703 LKQHEAQEEQRMLQAQKQYIELEMRKFKRKRMIMQHEHEDQQLRDELGKKEQQLQQAHAMLLKHH 767
            |:|.:|:||..:|:.|:||.||:.|::|||.::.:|..:...||::|.||:.|.....|:||:.|
Mouse   627 LQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQH 691

  Fly   768 EKTQELEYRQQKSVHQLREEQINKQHDTELHNQKDYMDRIKKELVRKHAVELRQQPKSLKQKELQ 832
            |.|:|||.||.::|.:.|.|....||.|||.||.:|..|.::||.:|||.::||||||||.:..|
Mouse   692 EATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQ 756

  Fly   833 IRKQFRETCKTQTKQYKRYKAQVLQT-TPKEQQ-----KEVIKQLKEEKHRKLTLLGEQYEQSIA 891
            :......|.....          |.| ||.|:|     :|.|...:        :|||:.|
Mouse   757 LPMGLPATGALGP----------LSTGTPSEEQPCSSGQEAILDQR--------MLGEEEE---- 799

  Fly   892 DMFQSQSYKLDESQVIECQRT----HEQ--LEYELEMLTAYQNKNKKQAQEQR---DRERRELE- 946
                    .:.|.:::..:.|    .||  |..|:...::...|::..|.|:.   ..|.:|:.
Mouse   800 --------AVPERRILGKEGTTLEPEEQRILGEEMGTFSSSPQKHRSLANEEDWDISEEMKEIRV 856

  Fly   947 -NRVSVRRGLLENKMDAELQQFNQE 970
             :..|..|.::..:..|....:.:|
Mouse   857 PSLASQERNIIGQEEAAAWSLWEKE 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	192/256 (75%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	190/252 (75%)
Taok2	NP_001157247.1	STKc_TAO2	12..319	CDD:270804	226/306 (74%)
		S_TKc	28..281	CDD:214567	190/252 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..463		41/215 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	899..946
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1212..1240
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	410	1.000	Domainoid score	I691
eggNOG	1	0.900	-	-		E1_KOG0577
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	990	1.000	Inparanoid score	I309
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D277938at33208
OrthoFinder	1	1.000	-	-		FOG0001318
OrthoInspector	1	1.000	-	-		otm43023
orthoMCL	1	0.900	-	-		OOG6_102967
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X816
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830