DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tao and hpo

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster

Alignment Length:	599	Identity:	168/599 - (28%)
Similarity:	242/599 - (40%)	Gaps:	173/599 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDILKEIRFLRQLNHPNT 87
            |||:|:.:.::|.||:|:||.|....:..|||||.:..     :....:|:|||..::|.:.|..
  Fly    38 PEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPV-----ESDLHEIIKEISIMQQCDSPYV 97

  Fly    88 IEYKGCYLRESTAWLVMEYC-VGSASDIIEVHKKPLHEDEIAAICLGVLSGLSYLHSLGRIHRDI 151
            :.|.|.|.::...|:.|||| .||.|||:.:.||.|.|||||.|....|.||.|||...:|||||
  Fly    98 VRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDI 162

  Fly   152 KAGNILLTDNGVVKLADFGSAA----IKCPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGI 212
            ||.||||...|..||||||.|.    .....|:.:|||:|||||||   :|..||...|:|||||
  Fly   163 KAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---EEIGYDCVADIWSLGI 224

  Fly   213 TCIELAERKPPYFNMNAMSALYHIAQNESPTLPKND-WSDAFCSFVELCLKKMPAERPSSAKLLT 276
            |.:|:||.||||..::.|.|::.|.|...|:..:.| ||..|..||..||.|.|.:|.::.:||.
  Fly   225 TALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLE 289

  Fly   277 HAYVTRPRSDTVLLELIARTKSAVRELDNLN---------------------------------- 307
            |.::...:..::|..::..| .|:||....|
  Fly   290 HEFIRNAKHRSILKPMLEET-CAIREQQRANRSFGGVLAASQAKSLATQENGMQQHITDNAFMED 353

  Fly   308 ---------------------------------------YRKMKK---------------ILMVD 318
                                                   .|.:.|               :..||
  Fly   354 PGTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLRNLSKAAAPAAASSAASPLDMPAVD 418

  Fly   319 T---CETESAVG------DTDD-----QQDD------------------HAGGDSSKSNSITSEH 351
            :   .|.||.:|      |:||     ..||                  :||........|.:|:
  Fly   419 SGTMVELESNLGTMVINSDSDDSTTAKNNDDQKPRNRYRPQFLEHFDRKNAGDGRGDEKPIATEY 483

  Fly   352 SIHSVGVSAASSQSSSSNSIPAAAQNHHHIAA--------HHHQQAASAAVAAAMHH---HHHPH 405
            |     .:||..|...........|:..|:|:        .|:.:.....::|...:   .|...
  Fly   484 S-----PAAAEQQQQQQQQQQQQQQDEQHLASGANDLNNWEHNMEMQFQQISAINQYGLQQHQQQ 543

  Fly   406 QQPPPSWP-SGQQGQPVPPGAVSRNSSRHRNRPPLPNIMHSMNNNVTPTNSASVVPAPAPAPVLP 469
            ||...::| ..:|       .::.|:.        ||::.|   |..|.....:   ||.||..|
  Fly   544 QQVLMAYPLMNEQ-------LIALNNQ--------PNLLLS---NAAPMGQQGI---PAAAPAQP 587

  Fly   470 PPISVLPHLSAMGH 483
            ||.....|:....|
  Fly   588 PPAYQNQHMHTQSH 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	114/262 (44%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	113/258 (44%)
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	116/262 (44%)
		S_TKc	42..293	CDD:214567	113/258 (44%)
		Mst1_SARAH	608..655	CDD:288481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438562
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940