DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tao and Myo3b

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_001380706.1	Gene:	Myo3b / 366069	RGDID:	1560313	Length:	1333	Species:	Rattus norvegicus

Alignment Length:	1112	Identity:	224/1112 - (20%)
Similarity:	383/1112 - (34%)	Gaps:	323/1112 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDILKEIRFLRQL-NHP 85
            ||...:|....||.|::|.||.........:.|:|.:.......:|    :..|...|:.| :||
  Rat    38 DPMDTWEIRETIGKGTYGKVYKVANRRDGSLAAVKILDSVNDVDEE----VEAEYNILQFLPSHP 98

  Fly    86 NTIEYKGCYLRESTA-----WLVMEYCVGSASDIIEVHK------KPLHEDEIAAICLGVLSGLS 139
            |.:::.|.:.:....     |||:|.|.|.:  :.|:.|      |.|.|..|:.|..|.|.||.
  Rat    99 NVVKFYGMFYKADRCVGGQLWLVLELCNGGS--VTELVKGLLRCGKRLDEALISYILYGSLLGLQ 161

  Fly   140 YLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAA----IKCPANSFVGTPYWMAPEVILAMD--E 198
            :||....||||:|..|||||..|.|||.|||.:|    .:...|:.||||:|||||||....  :
  Rat   162 HLHHHRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQQYD 226

  Fly   199 GQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTL--PKNDWSDAFCSFVELCL 261
            ..||.:.||||||||.|||.:..||.|.|:.:..|:.|.:|..|||  |.| |.:.|..|:..||
  Rat   227 SSYDARCDVWSLGITAIELGDGDPPLFEMHPVKMLFKIPRNPPPTLLHPDN-WCEEFNHFISQCL 290

  Fly   262 KKMPAERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKILMVDTCETESAV 326
            .|...:|||...||.|.::...:...:.|:                 :::.|:|.
  Rat   291 IKDFEKRPSVTHLLDHPFIKGTQGKVLFLQ-----------------KQLAKVLW---------- 328

  Fly   327 GDTDDQQDDHAGGDSSKSNSITSEHSIHSVGVSAASSQSSSSNSIPAAAQNH---HHIAAHHHQQ 388
                ||:..:                                   |.|...|   |....||.:.
  Rat   329 ----DQKHQN-----------------------------------PVAKTRHERMHTGRPHHVED 354

  Fly   389 AASAAVAAAMHHHHHPHQQPPPSWPSGQQGQP-----VPPGAVSRNSSRHRN--RPPLPNIMHSM 446
            |....:...:.:.....:.....|...:....     |....::.|..::.:  .|....:.|.:
  Rat   355 AGKCCLEDDLVNLEVLDEDTIIYWLQKRYADALIYTYVGDILIALNPFQNLSIYSPQFSRLYHGV 419

  Fly   447 NNNVTPTNSASVVPAPAPAPVLPPPISVLPHLSAMGH---------------VGGGGTGTGGSGG 496
            ..:..|                       ||:.|...               |..|.:|:|.:..
  Rat   420 KRSSNP-----------------------PHIFASADNAYQCLVTFSKDQCIVISGESGSGKTEN 461

  Fly   497 G----------SPASGGPLADRIQPVQPRYLTTPAAQAAVYAASSASSQQAISN---AVNDHGPN 548
            .          ..|:...|..:|..|.                   |..:|..|   |:||:...
  Rat   462 AHLIVQHLTFLGKANNQTLRQKILQVN-------------------SLVEAFGNARTAINDNSSR 507

  Fly   549 -----NFATIRTTSIVTKQQKEHMQEEMH--EQMSGYKRMR--------REHQAHLVKL---EEK 595
                 ......|.:::..:..|::.|:..  :|.:|.|...        ..||..|.:.   |||
  Rat   508 FGKYLEMMFTPTGAVMGARISEYLLEKSRVIQQAAGEKNFHIFYYIYAGLYHQKKLAEFRLPEEK 572

  Fly   596 CK--VDMEAHKTALD--------KEYDTLLHNF------------------------TRDLDRLE 626
            ..  :..|..:...|        :::|.:.|.|                        ..:...:.
  Rat   573 PPRYIAAETERVTQDITSKESYRRQFDVIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAIS 637

  Fly   627 TKHQQD---------VERRAKQTSAAEKKLHKEIT-----LKQENDRKVYDLNRKKEYK--ANKE 675
            ::||.|         :|..|.......::|.:.:|     .:.|...:...::|.::.:  .:|.
  Rat   638 SQHQTDKSEVPNPEALENAASVLCINSEELQEALTSHCVVTRGETIVRANTVDRAEDVRDAMSKA 702

  Fly   676 RWKRELS--MDESTPKRQRDLTLQSQKDNLK------------QHEAQE--------EQRMLQAQ 718
            .:.|..|  ::......|.|..:.|.:|.:.            |..:.|        ||......
  Rat   703 LYGRLFSWIVNRINTLLQPDKNICSAEDRMNVGILDIFGFEDFQRNSFEQLCINIANEQVQFYFN 767

  Fly   719 KQYIELEMRKFKRK---RMIMQHEHE----DQQLRDELG-----KKEQQLQQA--HAMLLKHHEK 769
            :....||..::|::   .:::|:|..    |..|:..||     .:|.:..|.  ..::.|..:.
  Rat   768 QHVFALEQMEYKKEGVDAVLVQYEDNRPLLDMFLQKPLGLLALLDEESRFPQGTDQTLVDKFEDN 832

  Fly   770 TQELEYRQQKSVHQLREEQINKQH--DTELHNQKDYMDRIKKELVRKHAVELRQQPKSLKQKELQ 832
            .:...:.:.|.|    |.....||  ...|::....:::.:..|.....|.||.....|.|:...
  Rat   833 LRCKFFWRPKGV----ELSFGIQHYAGPVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFS 893

  Fly   833 IRKQFRETCKTQTKQYKRYKAQVLQTT-----------PKEQQKEVIKQLKEEKHRKLTLLGEQY 886
            |.       .|:|....:.:|::..::           .|....|||:..:|..:.|...:...:
  Rat   894 IP-------LTKTGNLAQTRARITASSRSLPPHFSAGRAKVDTLEVIRHPEETTNMKRQTMASYF 951

  Fly   887 EQSIADMFQSQSYKLDESQVIECQRTHEQLEYELEMLTAYQNKNKKQAQEQRDRERRELEN---- 947
            ..|:.|:....  .:.:...:.|.:               .|.::|..|..:||...:|.:
  Rat   952 RYSLMDLLSKM--VVGQPHFVRCIK---------------PNDDRKALQFSQDRVLAQLRSTGIL 999

  Fly   948 -RVSVRR 953
             .||:||
  Rat  1000 ETVSIRR 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	103/276 (37%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	103/272 (38%)
Myo3b	NP_001380706.1	MYSc_Myo3	373..1062	CDD:276830	107/704 (15%)
		IQ	1102..1124	CDD:197470
		PKc_like	20..310	CDD:419665	105/278 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910