DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tao and plk3

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_958465.1	Gene:	plk3 / 334202	ZFINID:	ZDB-GENE-030131-6134	Length:	644	Species:	Danio rerio

Alignment Length:	407	Identity:	97/407 - (23%)
Similarity:	176/407 - (43%)	Gaps:	42/407 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PSARPGSLKD----PEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTG 62
            |.|:|...|.    ||:|.:.......:.:...:.:|.|.|...|........::.|:|.:..:.
Zfish    14 PPAKPSRSKSEHVKPELAQVVVDAKTGRSYCKGKLLGKGGFARCYEMTDLANNKMYAVKVIPQSR 78

  Fly    63 KQSQEKWQDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEI 127
            .....:.:.|:.||...:.|.|.:.:::...:..:...::.:|.|...:...|...:..|.:.|:
Zfish    79 VSKPHQREKIINEIELHKSLQHKHVVKFSHHFEDQDNIYIFLELCSRKSLAHIWKARHTLTDPEV 143

  Fly   128 AAICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAA----IKCPANSFVGTPYWM 188
            ......::|.|.|||:.|.:|||:|.||..:.:|..::|.|||.||    ::....:..|||.::
Zfish   144 RYYLRQIISSLKYLHNKGILHRDLKLGNFFVNENMELRLGDFGLAAKLETVEQRKKTICGTPNYL 208

  Fly   189 APEVILAMDEGQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSDAF 253
            ||||:.....|.   :.||||||.....|....||:..:: :...|...:....:|| :..:.:.
Zfish   209 APEVLNRQGHGT---ESDVWSLGCVMYTLLCGNPPFETLD-LKETYKCIKEVKYSLP-SSLTPSA 268

  Fly   254 CSFVELCLKKMPAERPSSAKLLTHAYVTR--------PRSDTVLLELIARTKSAVRELDNLNYRK 310
            ...:...|:|.|.:|.:..::|.|.|.|:        |.|..::.||  ...|..::.    :.|
Zfish   269 QKLISSILQKNPCDRLTLDQILAHDYFTKGFTPEKLPPSSCVMVPEL--NPPSPAKKF----FTK 327

  Fly   311 MKKILMVDTCETESAVGDTDDQQDDHAGGDSSK------SNSITSEHSIHSVGVSAASS---QSS 366
            |.|.|...  :....|..|..::.|    |.||      .:||..:.|..::||:.|:|   |.:
Zfish   328 MAKSLFGK--KKSKTVEKTTSEEKD----DISKLVSGMVKHSIGRQMSYKTMGVNEATSPTVQLA 386

  Fly   367 SSNSIPAAAQNHHHIAA 383
            ||..:...|:.....:|
Zfish   387 SSGPLDTPAEEESRKSA 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	62/260 (24%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	61/256 (24%)
plk3	NP_958465.1	STKc_PLK3	41..295	CDD:271091	61/258 (24%)
		S_TKc	43..295	CDD:214567	61/256 (24%)
		POLO_box_1	457..545	CDD:240561
		POLO_box_2	557..640	CDD:240560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910