DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tao and Taok3

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_001074777.1	Gene:	Taok3 / 330177	MGIID:	3041177	Length:	898	Species:	Mus musculus

Alignment Length:	1013	Identity:	477/1013 - (47%)
Similarity:	628/1013 - (61%)	Gaps:	123/1013 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RPGSLKDPEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKW 69
            |.|:||||||||||.|.|||::|.||.|||||||||||:|....|.|:||:|||||:|||:.|||
Mouse     2 RKGALKDPEIADLFFKDDPEELFIDLHEIGHGSFGAVYFATNAHTNEVVAVKKMSYSGKQTHEKW 66

  Fly    70 QDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAAICLGV 134
            ||||||::||:||.||||||||||||:|.|||||||||:|||||::|||||||.|.|||||..|.
Mouse    67 QDILKEVKFLQQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGA 131

  Fly   135 LSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPANSFVGTPYWMAPEVILAMDEG 199
            |.||:|||....|||||||||||||:.|.|||||||||::..|||||||||||||||||||||||
Mouse   132 LQGLAYLHFHSLIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEG 196

  Fly   200 QYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSDAFCSFVELCLKKM 264
            |||||||:||||||||||||||||.|||||||||||||||:||||...:|:|:|..||:.||.|:
Mouse   197 QYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSREWTDSFRRFVDYCLHKI 261

  Fly   265 PAERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKILMVDTCETESAVGDT 329
            |.|||::.:||.|.::.|.|...||::||.|||.||||||||.||||||||..:|..     |..
Mouse   262 PQERPAAVELLRHDFIRRERPPKVLIDLIQRTKDAVRELDNLQYRKMKKILFQETRN-----GPL 321

  Fly   330 DDQQDDHAGGDSSKS-----NSITSEHSIHSVGVSAASSQSSSSNSIPAAAQNHHHIAAHHHQQA 389
            ::.|::...|:...:     :|:.|.|||.|..||..|..||.::......::...:......:.
Mouse   322 NESQEEEEDGEQGSNLNREVDSLGSIHSIPSTSVSTGSRSSSVNSMQEVMDESSSELVMMQEDEG 386

  Fly   390 ASAAVAAAMHHHHHPHQQPPPSWPSGQQGQPVPPGAVSRNSSRHRNRPPLPNIMHSMNNNVTPTN 454
            .:.:.|:.:|...|                     ...|:.:.|.:
Mouse   387 TANSSASTVHKKDH---------------------VFVRDEAGHGD------------------- 411

  Fly   455 SASVVPAPAPAPVLPPPISVLPHLSAMGHVGGGGTGTGGSGGGSPASGGPLADRIQPVQPRYLTT 519
                 |.|.|.|.                                          |.||
Mouse   412 -----PRPEPRPT------------------------------------------QSVQ------ 423

  Fly   520 PAAQAAVYAASSASSQQAISNAVNDHGPNNFATIRTTSIVTKQQKEHMQE-EMHEQMSGYKRMRR 583
                               |.|::......||||::.|:||:|..||.|| |:.|||||||||||
Mouse   424 -------------------SRALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRR 469

  Fly   584 EHQAHLVKLEEKCKVDMEAHKTALDKEYDTLLHNFTRDLDRLETKHQQDVERRAKQTSAAEKKLH 648
            :||..|:.||.|.|.:|:.|:..|.||.:|..:|.:.:|::|..|....:|:.||..:|.|||..
Mouse   470 QHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVATIEKEAKVAAADEKKFQ 534

  Fly   649 KEITLKQENDRKVYDLNRKKEYKANKERWKRELSMDESTPKRQRDLTLQSQKDNLKQHEAQEEQR 713
            ::|..:|:.|...:..::||:||..||:.|.|::.|.||||:::...:...|:||:..:|:||..
Mouse   535 QQILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAH 599

  Fly   714 MLQAQKQYIELEMRKFKRKRMIMQHEHEDQQLRDELGKKEQQLQQAHAMLLKHHEKTQELEYRQQ 778
            :|..|:.|.:...|.||||.||.:||.|.|.:|:||.||..|.:..||||::|.|.|:||||||.
Mouse   600 LLTQQRLYYDRNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQL 664

  Fly   779 KSVHQLREEQINKQHDTELHNQKDYMDRIKKELVRKHAVELRQQPKSLKQKELQIRKQFRETCKT 843
            .::.:||.:.|..||.|||.||.:|..|.::||.|||.:|||||||:||..|:||:|||::|||.
Mouse   665 HTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKV 729

  Fly   844 QTKQYKRYKAQVLQTTPKEQQKEVIKQLKEEKHRKLTLLGEQYEQSIADMFQSQSYKLDESQVIE 908
            ||||||..|...|:.|||.:.|.::|.||:|:.|||.:|.|||||||.:|..||:.:|||:|..|
Mouse   730 QTKQYKALKNHQLEVTPKNEHKAILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAE 794

  Fly   909 CQRTHEQLEYELEMLTAYQNKNKKQAQEQRDRERRELENRVSVRRGLLENKMDAELQQFNQERAE 973
            ||....||:.|:|:|.|||:|.|.|.:.|.:||.::||.|||:||..||.|::.||....:||:|
Mouse   795 CQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSE 859

  Fly   974 RLRMKHEKHTKELEAFDNESIALGFSTLSLIEVSREAY 1011
            |::...|:..:|.|.||.||:.:||..|..::..:|.|
Mouse   860 RIKTLLERQERETETFDMESLRMGFGNLVTLDFPKEDY 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	190/256 (74%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	190/252 (75%)
Taok3	NP_001074777.1	PKc_like	2..314	CDD:389743	231/311 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..375		15/63 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..424		8/109 (7%)
		PTZ00121	<415..881	CDD:173412	219/532 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	565..596		10/30 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	453	1.000	Domainoid score	I503
eggNOG	1	0.900	-	-		E1_KOG0577
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	990	1.000	Inparanoid score	I309
Isobase	1	0.950	-	0	Normalized mean entropy	S1315
OMA	1	1.010	-	-		QHG48447
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001318
OrthoInspector	1	1.000	-	-		otm43023
orthoMCL	1	0.900	-	-		OOG6_102967
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X816
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780