DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tao and rock2a

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_777288.1	Gene:	rock2a / 317747	ZFINID:	ZDB-GENE-030115-3	Length:	1375	Species:	Danio rerio

Alignment Length:	1224	Identity:	243/1224 - (19%)
Similarity:	468/1224 - (38%)	Gaps:	333/1224 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PGSLKDPEIADLFNKHDPEKIFEDLRE-------------IGHGSFGAVYYARCNLTREIVAIKK 57
            |...|:..|.:..|::  ||:...:||             ||.|:||.|...|...::::.|:|.
Zfish    46 PALRKNKNIENFLNRY--EKVMNHIRELQMRPEDFDRVKVIGRGAFGEVQLVRHKASQKVYAMKV 108

  Fly    58 MSYTGKQSQEKWQD---ILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVG-------SAS 112
            :|   |....|..|   ..:|...:...:.|..::....:..:.:.::||||..|       |..
Zfish   109 LS---KFEMIKRSDSAFFWEERDIMAFADSPWVVQLCCAFQDDRSLYMVMEYMPGGDLVNLTSTY 170

  Fly   113 DIIEVHKKPLHEDEIAAICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADF-------G 170
            |:.|...|....:.:.|        |..:||:|.||||:|..|:||...|.:|||||       |
Zfish   171 DVPEKWAKFYTAEVVLA--------LDAIHSMGFIHRDVKPDNMLLDRYGHLKLADFGTCMKMDG 227

  Fly   171 SAAIKCPANSFVGTPYWMAPEVILAM-DEGQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALY 234
            :..:.|  ::.||||.:::|||:.:. .:|.|..:.|.||:|:...|:.....|::..:.:....
Zfish   228 TGMVHC--DTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYS 290

  Fly   235 HIAQNE-SPTLP-----KNDWSDAFCSFVELCLKKMPAERPSSAKLLTHAYVTRPRSDTVLLELI 293
            .|..:: |...|     ..:..:..|:|  |..:::...|....::..|.:.   |:|......|
Zfish   291 KIMDHKNSLNFPDDVEISQEGKNIICAF--LTDREVRLGRSGVEEIKRHPFF---RNDQWTFSTI 350

  Fly   294 ARTKSAV-----RELDNLNYRKMKKIL-MVDTCETESA-VGDTDDQQDDHAGGDSSKSNSITSEH 351
            ..|.:.|     .::|..|:.::::.. .|:|..|..| ||:    |....|....|.|.:.
Zfish   351 RETAAPVVPELSSDIDTSNFDEIEEDKGEVETFPTPKAFVGN----QLPFVGFTYFKENQLL--- 408

  Fly   352 SIHSVGVSAASSQSSSSNSIPAAAQNHHHIAAHHHQQAASAAVAAAMHHHHHPHQQPPPSWPSGQ 416
                             |::.::|..:.|..::.....|.......:....:...|
Zfish   409 -----------------NAVNSSAMKNDHPVSNREDNLALQKKLHCLEEQLNNEMQ--------- 447

  Fly   417 QGQPVPPGAVSRNSSRHR-NRPPLPNIMHSMNNNVTPTNSASVVPAPAPAPVLPPPISVLPHLSA 480
                    |......::| |...|..|...::..:   ||...:.:....  |....::|.|.|.
Zfish   448 --------AKDELEQKYRSNSNRLEKITKELDEEM---NSRKGLESTLRQ--LEREKALLQHKSV 499

  Fly   481 MGHVGGGGTGTGGSGGGSPASGGPLADRIQPVQPRYLTTPAAQAAVYAASSASSQQAISNAVNDH 545
            ..|                                          ..|.|.|..::.:.|.||
Zfish   500 ESH------------------------------------------RRAESEADRKRCLENEVN-- 520

  Fly   546 GPNNFATIR----------TTSIVTKQQKEHMQEEMHE-------QMSGYKRMRR---------- 583
                  ::|          ..|.::.::..|:|:::.|       :.....|||:
Zfish   521 ------SLRDQLDEMKKKNQNSHISNEKNIHLQKQLDEANALLRAESEVATRMRKTQTESSKQLQ 579

  Fly   584 EHQAHLVKLEEKC------KVDMEAHKTALDKEYDTLLHNFTR------DLDRLETKHQQDVERR 636
            :.:||:.:|::||      |:.:|....:|....||.....|:      ||....|..:.:|.:.
Zfish   580 QLEAHVRELQDKCCMLENSKLTLERENISLQAALDTEKREQTQGSETISDLQARITGMEDEVRQM 644

  Fly   637 AKQTSAAE---KKLHKEIT-LKQENDRKVYDLNRKKEYKANKERWKRELSMDESTPKRQRDLTLQ 697
            .:..|.||   ::|.:::| :::|......|:..|  .|..::..::|.:..::|..|..|..:.
Zfish   645 RQALSKAETEKRQLQEKLTDMEKEKSNNQIDMTYK--LKMLQQGLEQEEAAHKATKARLADKNMI 707

  Fly   698 SQK-DNLKQHEAQEEQRMLQ---AQKQYIELEMRKFKRKRMIMQHEHEDQQLRDELGKKEQQLQQ 758
            |:. :..|....:|.::.||   :.||.:|..:.:.::|..::     |...:..|.|.|:
Zfish   708 SESIEGAKSEAVKELEQKLQEERSSKQRVENRVLELEKKNSML-----DCDYKQSLQKLEE---- 763

  Fly   759 AHAMLLKHHEKTQELEYRQQKSVHQLREEQINK----QHDTELHNQK---------------DYM 804
                |.:|.|:..|    :.|:::...|:::.|    |:|.::.||:               :::
Zfish   764 ----LRRHKERLTE----EVKNLNLKIEQEVQKRTLTQNDLKVQNQQLSTLRTSEKQLKQEINHI 820

  Fly   805 DRIKKELVRKHAVELR--QQPKSLKQKELQIR---------------KQFRETCKTQTKQYKRYK 852
            ..||:.| .|..:|||  :|....:.||||.:               ::.:|.|:.:.|.||..:
Zfish   821 LEIKRSL-EKQNMELRKERQDSDGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKNKLYKDVQ 884

  Fly   853 --------------AQVLQTTPKEQQKEVIKQLKEEKHRKLTLLGEQYEQSIADMFQSQSYKLDE 903
                          ||:..|..|...:::.:.:.||::..|.......|..|.:|......:|.|
Zfish   885 QNLQELQEERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHRQELAE 949

  Fly   904 -----SQVIECQRT---------HEQLEYELEMLTA---YQN-KNKKQA--------QEQRDRER 942
                 |.:.|..||         :|:.|:..::..|   .|| ||::|:        ::|...||
Zfish   950 KDTTISSLEEANRTLTSDVANLANEKEEFNNKLKEAEDYLQNLKNEEQSITQVKLALEKQLQSER 1014

  Fly   943 ----------RELENRVSVRRGLLENKMDAELQQFNQE--------RAERLRM-----KHEKHTK 984
                      .|:.||..||.|......|.::::..:|        |:||.::     |:::...
Zfish  1015 TLKTQAVNKLAEIMNRKEVRGGGSRRGNDTDVRRKEKENRKLQLELRSEREKLNSTIIKYQREIN 1079

  Fly   985 ELEA--FDNESIALGFSTLSLIEVSREAYADEEGSLSGSM-ISLAHSNSSTSFP 1035
            :::|  .|...:.:   .|.:...|:::..::..||..|: :....|.|.:|.|
Zfish  1080 DIQAQLLDESQVRI---ELQMALDSKDSDIEQLRSLLNSLNVQSLDSASMSSGP 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	71/293 (24%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	70/289 (24%)
rock2a	NP_777288.1	STKc_ROCK2	25..403	CDD:270771	91/380 (24%)
		S_TKc	78..340	CDD:214567	68/276 (25%)
		DUF4631	431..1028	CDD:292090	124/688 (18%)
		HR1_ROCK2	491..557	CDD:212028	15/115 (13%)
		Rho_Binding	965..1032	CDD:286056	14/66 (21%)
		PH_ROCK	1141..1246	CDD:269948
		C1	1250..1304	CDD:237996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910