DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tao and Plk5

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	XP_006240983.1	Gene:	Plk5 / 314627	RGDID:	1305038	Length:	614	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	114/505 - (22%)
Similarity:	187/505 - (37%)	Gaps:	74/505 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LKDPEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDIL 73
            |:||         ...:::...:.||.|:|...|......|..:.|:|.:...|.........:.
  Rat    18 LRDP---------GSGRVYRRGKLIGKGAFSRCYKLTDMSTSAVFALKVVPRGGAGRLRLRGKVE 73

  Fly    74 KEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCV-GSASDIIEVHKKPLHEDEIAAICLGVLSG 137
            :||....:|:|.|.:.:...:......::|:|||. .|.:.:::| ::.|.|.|:.....|::||
  Rat    74 REIALHSRLHHRNIVAFHAHFADRDHVYMVLEYCSRQSLAHVLKV-RRTLTEPEVRYYFRGLVSG 137

  Fly   138 LSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPANS----FVGTPYWMAPEVILAMDE 198
            |.|||....:|||:|..|..|..|..||:.|.|.||...||..    ..|||.:.||||:   ..
  Rat   138 LRYLHQQRIVHRDLKPSNFFLNKNMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVV---SR 199

  Fly   199 GQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQN--ESPTLPKNDWSDAFCSFVELCL 261
            ..:..|.|:|:||.....:....||:    |.:.|..:.||  :...|.....|.:..|.:...|
  Rat   200 NGHSAKSDIWALGCIMYTVLTGTPPF----AAAPLSEMYQNIRDGHYLEPTQLSPSARSLIARLL 260

  Fly   262 KKMPAERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVR---ELDNLNYRKMKKILMVD----- 318
            ...|.||||...||...:.::..:...|......:.....   .|..| :||:.::|:..
  Rat   261 APDPDERPSLDHLLQDDFFSQGFTPERLPPHSCHSPPVFAFPPPLGRL-FRKVGQLLLTQCRPPC 324

  Fly   319 --TCETESAVGDTDDQQDDHAGGDSSKSNSITSEHSIHSVGVSAASSQSSSSNSIPAAAQN---- 377
              |.:..|..|: :..:.||....:.:...:.:|..||.:.:....:.       ||.|:.
  Rat   325 PFTSKEASGPGE-ESTEPDHMEASNEEGAPLCTESRIHLLTLGTPRTD-------PADAKGTLAL 381

  Fly   378 HHHIAAHH-----------HQQAASAAVAAAMHHHHHPHQQPP---------PSWPS-------G 415
            ...:|...           ..........||........|.||         |.|..       |
  Rat   382 QLEVATRKLCLCLDAGPVGRTATPKCRTEAAWRGPKPAGQDPPGEQRSVLWAPKWVDYSLKYGFG 446

  Fly   416 QQGQPVPPGAVSRNSSRHRNRPPLPNIMHSMNNNVTPTNSASVVPAPAPA 465
            .|......|.:.|:.|....|||..::.:..:.......:...||.|..|
  Rat   447 YQLSDGGSGVLFRDGSHMALRPPGGHVSYQPDQGTLWIFALRDVPGPLRA 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	74/263 (28%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	74/259 (29%)
Plk5	XP_006240983.1	STKc_PLK	25..279	CDD:271001	74/261 (28%)
		S_TKc	27..279	CDD:214567	74/259 (29%)
		POLO_box_1	429..516	CDD:240561	14/68 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910