DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tao and Taok1

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_775449.2	Gene:	Taok1 / 286993	RGDID:	708455	Length:	1001	Species:	Rattus norvegicus

Alignment Length:	1040	Identity:	507/1040 - (48%)
Similarity:	667/1040 - (64%)	Gaps:	125/1040 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPSA-RPGSLKDPEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQ 64
            |||. |.|||||||||:||.|.||||:|.||||||||||||||:||...|.|:||||||||:|||
  Rat     1 MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQ 65

  Fly    65 SQEKWQDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAA 129
            |.||||||:||::||:::.|||:||||||||||.|||||||||:|||||::|||||||.|.||||
  Rat    66 STEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAA 130

  Fly   130 ICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPANSFVGTPYWMAPEVIL 194
            |..|.|.||:||||...|||||||||||||:.|.|||||||||::..||||||||||||||||||
  Rat   131 ITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVIL 195

  Fly   195 AMDEGQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSDAFCSFVEL 259
            |||||||||||||||||||||||||||||.||||||||||||||||||||..|:|||.|.:||:.
  Rat   196 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDS 260

  Fly   260 CLKKMPAERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKILMVDTCETES 324
            ||:|:|.:||:|.:||.|.:|.|.|.:|||::||.|||.||||||||.||||||:|..:.....:
  Rat   261 CLQKIPQDRPTSEELLKHMFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPA 325

  Fly   325 AVGDTDDQQDDHAGGDSSKSNSITSEHSIHSVGVSAASSQSSSSNSIPAAAQNHHHI---AAHHH 386
            .....::::.||.||.:...||:.|..||.|:.:| |||||||.||:|.|:.:...:   ...|.
  Rat   326 VEAQEEEEEQDHGGGRTGTVNSVGSNQSIPSMSIS-ASSQSSSVNSLPDASDDKSELDMMEGDHT 389

  Fly   387 QQAASAAVAAAMHHHHHPHQQPPPSWPSGQQGQPVPPGAVSRNSSRHRNRPPLPNIMHSMNNNVT 451
            ..:.|:.:.......::..:..|.:    :...|..|..|||:.|.:|||
  Rat   390 VMSNSSVIHLKPEEENYQEEGDPRT----RASDPQSPPQVSRHKSHYRNR--------------- 435

  Fly   452 PTNSASVVPAPAPAPVLPPPISVLPHLSAMGHVGGGGTGTGGSGGGSPASGGPLADRIQPVQPRY 516

  Rat   436 ----------------------------------------------------------------- 435

  Fly   517 LTTPAAQAAVYAASSASSQQAISNAVNDHGPNNFATIRTTSIVTKQQKEHMQE-EMHEQMSGYKR 580
                                           .:||||||.|:||:|.:||.|: |:.||||||||
  Rat   436 -------------------------------EHFATIRTASLVTRQMQEHEQDSELREQMSGYKR 469

  Fly   581 MRREHQAHLVKLEEKCKVDMEAHKTALDKEYDTLLHNFTRDLDRLETKHQQDVERRAKQTSAAEK 645
            |||:||..|:.||.|.|.:|:.|:..|||:.:|..:||..::::|..|||..:|:.||..:..||
  Rat   470 MRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQASMEKEAKVMANEEK 534

  Fly   646 KLHKEITLKQENDRKVYDLNRKKEYKANKERWKRELSMDESTPKRQRDLTLQSQKDNLKQHEAQE 710
            |..:.|..:|:.:...:..::|:|||..||:.|.||:.::||||:::...|..||:|::..:|:|
  Rat   535 KFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEE 599

  Fly   711 EQRMLQAQKQYIELEMRKFKRKRMIMQHEHEDQQLRDELGKKEQQLQQAHAMLLKHHEKTQELEY 775
            |..:|:.|:||:|||.|:|||:.::.:|..|...:|:||.|::.|....|||||:.||..||||:
  Rat   600 EANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEF 664

  Fly   776 RQQKSVHQLREEQINKQHDTELHNQKDYMDRIKKELVRKHAVELRQQPKSLKQKELQIRKQFRET 840
            |...::.::|.|.|..||.|||.||.:|..|.::||.|||.:|:||||||||.|||||:|||::|
  Rat   665 RHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDT 729

  Fly   841 CKTQTKQYKRYKAQVLQTTPKEQQKEVIKQLKEEKHRKLTLLGEQYEQSIADMFQSQSYKLDESQ 905
            ||.||:|||..:..:|:||||.:.|.|:|:||||:.|||.:|.|||:.||.:|..:|:.:|||:|
  Rat   730 CKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQ 794

  Fly   906 VIECQRTHEQLEYELEMLTAYQNKNKKQAQEQRDRERRELENRVSVRRGLLENKMDAELQQFNQE 970
            ..|||....||:.|||:|.|||:|.|.||:.|.|||.||||.|||:||.|||.|::.|:.....|
  Rat   795 EAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNE 859

  Fly   971 RAERLRMKHEKHTKELEAFDNESIALGFSTLSLIEVSREAYADEEGSLSGSMISLAHSNSSTSFP 1035
            |.||:|...|:..:|:||||:||:.||||.:.|..:|.||::......|    |.:|:.:..|.|
  Rat   860 RTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGAS----SWSHNPTGGSGP 920

Fly 1036 1035
Rat 921 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	198/256 (77%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	196/252 (78%)
Taok1	NP_775449.2	STKc_TAO1	2..318	CDD:270805	241/315 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..380		22/56 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	404..431		6/30 (20%)
		SbcC	<442..>877	CDD:223496	208/434 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	567..587		8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	905..1001		5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	455	1.000	Domainoid score	I478
eggNOG	1	0.900	-	-		E1_KOG0577
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H27041
Inparanoid	1	1.050	994	1.000	Inparanoid score	I284
OMA	1	1.010	-	-		QHG48447
OrthoDB	1	1.010	-	-		D277938at33208
OrthoFinder	1	1.000	-	-		FOG0001318
OrthoInspector	1	1.000	-	-		otm45088
orthoMCL	1	0.900	-	-		OOG6_102967
Panther	1	1.100	-	-	LDO	PTHR48015
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X816
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840