DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tao and plk1

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_001003890.3	Gene:	plk1 / 280649	ZFINID:	ZDB-GENE-021115-7	Length:	595	Species:	Danio rerio

Alignment Length:	351	Identity:	100/351 - (28%)
Similarity:	159/351 - (45%)	Gaps:	29/351 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PSARPGSLKDPEIADLFNKHDPEKIFEDL--------REIGHGSFGAVYYARCNLTREIVAIKKM 58
            |||:|.:..||:.|.|  |..|:.:.:..        |.:|.|.|...|......|:|:.|.|.:
Zfish     8 PSAKPSAHVDPKSAPL--KEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVV 70

  Fly    59 SYTGKQSQEKWQDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHK--KP 121
            ..:......:.:.:..||...:.|::|:.:.:.|.:..:...::|:|.|  ....::|:||  |.
Zfish    71 PKSMLLKPHQKEKMSTEIAIHKSLDNPHVVGFHGFFEDDDFVYVVLEIC--RRRSLLELHKRRKA 133

  Fly   122 LHEDEIAAICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAA-IKCPA---NSFV 182
            :.|.|........:.|:.|||:...||||:|.||:.|.|:..||:.|||.|. |:...   .:..
Zfish   134 VTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKTLC 198

  Fly   183 GTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALY-HIAQNESPTLPK 246
            |||.::||||:.   :..:..:||:||||.....|...||| |..:.:...| .|.:||. ::|:
Zfish   199 GTPNYIAPEVLC---KKGHSFEVDIWSLGCILYTLLVGKPP-FETSCLKETYIRIKKNEY-SVPR 258

  Fly   247 NDWSDAFCSFVELCLKKMPAERPSSAKLLTHAYVTR----PRSDTVLLELIARTKSAVRELDNLN 307
            : .:....:.:...|...|..|||.|:|||..:.|.    .|..|..|.:..|...|...||...
Zfish   259 H-INPVASALIRRMLHADPTLRPSVAELLTDEFFTSGYAPMRLPTSCLTVPPRFSIAPSSLDPAL 322

  Fly   308 YRKMKKILMVDTCETESAVGDTDDQQ 333
            .||....|...|......:|..|..|
Zfish   323 LRKPLSSLNKGTDSPIEEMGKMDQPQ 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	75/271 (28%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	75/267 (28%)
plk1	NP_001003890.3	STKc_PLK1	31..295	CDD:271089	76/271 (28%)
		S_TKc	39..291	CDD:214567	75/259 (29%)
		POLO_box_1	398..485	CDD:240561
		POLO_box_2	500..581	CDD:240560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910