DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tao and Map3k12

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_001157115.1	Gene:	Map3k12 / 26404	MGIID:	1346881	Length:	888	Species:	Mus musculus

Alignment Length:	716	Identity:	163/716 - (22%)
Similarity:	265/716 - (37%)	Gaps:	165/716 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NKHDPEKIFE-------DLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDILKE- 75
            :|...|.::|       ||:.:|.|:.|||:..|.:  .|.||:||:           :| |||
Mouse   143 HKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKV-----------RD-LKET 193

  Fly    76 -IRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCV-GSASDIIEVHKKPLHEDEIAAICLGVLSGL 138
             |:.||:|.|||.|.:||...:.....::||:|. |...:::.. .:|:....:....:|:..|:
Mouse   194 DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRA-GRPVTPSLLVDWSMGIAGGM 257

  Fly   139 SYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSA---AIKCPANSFVGTPYWMAPEVILAMDEGQ 200
            :|||....||||:|:.|:|:|.:.|||::|||::   :.|....||.||..|||||||......:
Mouse   258 NYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSE 322

  Fly   201 YDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSDAFCSFVELCLKKMP 265
               |||:||.|:...||...:.||.::::.:.::.:..|.......:...|.|...:..|....|
Mouse   323 ---KVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKP 384

  Fly   266 AERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKILMVDTC----ETESAV 326
            ..|||..::|.|..:......:...|...::::..||...|::.|:|.   ..||    |.|..:
Mouse   385 RNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKS---EGTCLHRLEEELVM 446

  Fly   327 GDTDDQQD-----DHAGGDSSKSNSITSEHSIHSVGVSAAS-----SQSSSSNSIPAAAQNHHHI 381
            ...::.:.     :|......::|::..|.:...:.:....     .:.:.....|...::|...
Mouse   447 RRREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKSHPSR 511

  Fly   382 AAHHHQQAASAAVAAAMHHHHHPHQQPP---------------------PSWPSGQQGQPVPPGA 425
            ...|............:.....||.:.|                     |..|.|    |..||.
Mouse   512 GLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKG----PPSPGR 572

  Fly   426 VSRNSSRHRN-------------RPPLPNIMHSMNNNVTPTNSASVVPAPAPAPVLPPPISVLPH 477
            ..|..:|||.             |..||  .|......:|   ..:...|:.....||.:..|.|
Mouse   573 SRRGKTRHRKASAKGSCGDLPGLRAALP--PHEPGGLGSP---GGLGVGPSAWDACPPALRGLHH 632

  Fly   478 ---------------LSAMGHVGGGGTG--------------TGGSGGGSPAS------GGPLAD 507
                           .:|:|..|.|.||              |..|.|.:|.|      ||...:
Mouse   633 DLLLRKMSSSSPDLLSAALGARGRGATGGARDPGSPPPPQGDTPPSEGSAPGSTSPDSPGGAKGE 697

  Fly   508 RIQPVQP----RYLTTPAAQAAVYAASSASSQQAISNAVNDHGPNNFATIRTTSIVTKQQKEHMQ 568
            ...||.|    ..|.|.....|....:.|.||....           |.:...:.||:.||..:.
Mouse   698 PPPPVGPGEGVGLLGTGREGTAGRGGNRAGSQHLTP-----------AALLYRAAVTRSQKRGIS 751

  Fly   569 EEMHEQMSGYKRMRREHQAHLVKLEEKCKVDMEAHKTALDKEYDTLLHNFTRDLDRLETKHQQDV 633
            .|                      ||:.:||.|.......:....  .|..:.|....:::..||
Mouse   752 SE----------------------EEEGEVDSEVELPPSQRWPQG--PNMRQSLSTFSSENPSDV 792

  Fly   634 E 634
            |
Mouse   793 E 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	84/269 (31%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	84/265 (32%)
Map3k12	NP_001157115.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..104
		STKc_MAP3K12_13	164..400	CDD:270961	81/253 (32%)
		Leucine-zipper 1	423..444		6/23 (26%)
		Leucine-zipper 2	476..497		0/20 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	557..612		15/63 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..888		36/175 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910