DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tao and Tesk1

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_035701.3	Gene:	Tesk1 / 21754	MGIID:	1201675	Length:	627	Species:	Mus musculus

Alignment Length:	547	Identity:	119/547 - (21%)
Similarity:	193/547 - (35%)	Gaps:	151/547 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 FEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDILKEIRFLRQLNHPNTIEYK 91
            |:...:||.|.|..||..|...:.:::.:|.......:|     :.|:|::.:.:|.|||.:.:.
Mouse    52 FDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRS-----NTLREVQLMNRLRHPNILRFM 111

  Fly    92 GCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAAICLGVLSGLSYLHSLGRIHRDIKAGNI 156
            |..:.:.....:.||..|...:.:....:||.......:.|.:..||.|||:.|..|||:.:.|.
Mouse   112 GVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIAQGLRYLHAKGVFHRDLTSKNC 176

  Fly   157 LL--TDNG-VVKLADFGSAAIKCPAN---------SFVGTPYWMAPEVILAMDEGQ-YDGKVDVW 208
            |:  .|.| ...:.|||.|. |.|..         :.||:||||||||:    .|: ||.|.||:
Mouse   177 LVRREDRGFTAVVGDFGLAE-KIPVYREGTRKEPLAVVGSPYWMAPEVL----RGELYDEKADVF 236

  Fly   209 SLGITCIELAER---KPPY------FNMNAMSALYHIAQNESPTLPKNDWSDAFCSF-------- 256
            :.||...||..|   .|.|      |.:: :.|...:..|:.| ||....:...||.
Mouse   237 AFGIVLCELIARVPADPDYLPRTEDFGLD-VPAFRTLVGNDCP-LPFLLLAIHCCSMEPSTRAPF 299

  Fly   257 ------VELCLKKMPAERPSSAKLLTHA--------------YVTRPRSDTVLLELIARTKSAVR 301
                  :|..|::.|...|.:...||.|              ..|.||.|..|    :|::|
Mouse   300 TEITQHLEQILEQQPEATPLAKPPLTKAPLTYNQGSVPRGGPSATLPRPDPRL----SRSRS--- 357

  Fly   302 ELDNLNYRKMKKILMVDTCETESAVGDTDDQQDDHAGGDSSKSNSITSEHSIHSVGVSAASSQSS 366
                       .:.:..:.|:..:.||           :.::.|..:....:....:....:...
Mouse   358 -----------DLFLPPSPESPPSWGD-----------NLTRVNPFSLREDLRGGKIKLLDTPCK 400

  Fly   367 SSNSIPAAAQNHHHIAAHHHQQAASAAVAAAMHHHHHPHQQPPPSWPSGQQGQPVPPGAVSRNSS 431
            .:..:|..                                 ||....|.|......|..:.:..:
Mouse   401 PATPLPLV---------------------------------PPSPLTSTQLPLVTTPDILVQPET 432

  Fly   432 ---RHRNRPPLPNIMHSMNNNVTPTNSASVVPAPAPAPV--------------LPPPISVLPHLS 479
               |.|:.|..|.:         |....:.:|.|.|:|:              .|.|..:.|.|.
Mouse   433 PVRRCRSLPSSPEL---------PRRMETALPGPGPSPMGPTEERMDCEGSSPEPEPPGLAPQLP 488

  Fly   480 -AMGHVGGGGTGTGGSGGGSPASGGPL 505
             |:.......|.:..|...||.||.||
Mouse   489 LAVATDNFISTCSSASQPWSPRSGPPL 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	80/304 (26%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	80/302 (26%)
Tesk1	NP_035701.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		TyrKc	56..306	CDD:197581	72/261 (28%)
		PKc_TESK	58..312	CDD:271057	74/265 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..373		12/74 (16%)
		Required for interaction with YWHAB. /evidence=ECO:0000250\|UniProtKB:Q63572	421..525		23/104 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..485		11/57 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..519		7/16 (44%)
		Required for interaction with SPRED1 and SPRY2. Required for TESK1-mediated dephosphorylation of SPRY2 and SPRY2 inhibition of ERK phosphorylation. /evidence=ECO:0000250\|UniProtKB:Q63572	528..627
		Required for interaction with PARVA. /evidence=ECO:0000250\|UniProtKB:Q63572	528..625
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910