DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tao and wnk-1

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_001294032.1	Gene:	wnk-1 / 177743	WormBaseID:	WBGene00006941	Length:	1850	Species:	Caenorhabditis elegans

Alignment Length:	730	Identity:	160/730 - (21%)
Similarity:	264/730 - (36%)	Gaps:	174/730 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 EIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDILKEIRFLRQLNHPNTIEYKG---- 92
            |:|.|||..|:......|...||..::. ..|.::.:.|...:|...|:.|.|||.:.:..
Worm   339 ELGRGSFKTVFRGLDTETGVAVAWCELQ-ESKLNKTERQRFREEAEMLKDLQHPNIVRFYDYWES 402

  Fly    93 ---CYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAAICLGVLSGLSYLHSLGR--IHRDIK 152
               |..|:... ||.|........:.....|.::...:.:.|..:|.|||:||:...  ||||:|
Worm   403 ADLCGKRKYIV-LVTELMTSGTLKMYLKRFKRINIKVLKSWCRQILKGLSFLHTRNPPVIHRDLK 466

  Fly   153 AGNILLT-DNGVVKLADFGSAAIKCP--ANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITC 214
            ..||.:| ..|.||:.|.|.|.:|..  |.|.:|||.:||||    |.|..||..|||::.|:..
Worm   467 CDNIFITGTTGSVKIGDLGLATLKNKSFAKSVIGTPEFMAPE----MYEEMYDESVDVYAFGMCL 527

  Fly   215 IELAERKPPYFN-MNAMSALYHIAQNESPTLPKNDWSDAFCSFVELCLKKMPAERPSSAKLLTHA 278
            :|:...:.||.. ||..:....:.....|.                |..::||:.|...:::...
Worm   528 LEMVTGEYPYSECMNPATIYRKVISGVKPE----------------CFSRIPAQYPEIREIIDRC 576

  Fly   279 Y-VTRPRSDTV-------------LLELIARTKSAVRELDNLNY-----------RKMKKILMVD 318
            . |.|....||             |:.:....|:...:|::||.           :|.|:....:
Worm   577 IRVRREERSTVKQLLVDDFFTPEDLIGIRVEIKNRDADLNDLNVEIQMQLRVYDEKKRKQYRFKE 641

  Fly   319 TCETESAVGDTDDQQDD---------HAGGDSS---------KSNSITSEHSIHSVGVSAASSQS 365
            ....:.|....:|..|:         |...:.:         |.::...:.....:.:..|..:.
Worm   642 NEGLQFAFDIENDSPDEVVQQMIEQQHIPDEDTRMITKLIKDKVDAFRRDRDHRLLEIKRAKEEE 706

  Fly   366 SSSNS-----------IPAAAQNHHHIAAHHHQQAASAAVAAAMHHHHHPHQQPPPSWP----SG 415
            .....           ..|..:....:.....::.|:||.||      :|:..|.|..|    |.
Worm   707 ERIREEAEIKEELRLRAEAKEKEKERLEKERLEKKAAAAAAA------NPNPTPIPPTPATPHSS 765

  Fly   416 QQGQPVPPGAVSRNSSRHRNRPPLPNIMHSMNNNV---TPTNSASVVPAPAPAPVLPPPISVLPH 477
            .|.||:||...::.|:..:.....|::..:|..|:   :||::       .|.|||.|..:.:|.
Worm   766 AQQQPIPPPLSTQTSAEIQQSAQQPSVPVTMIANIPAMSPTSA-------QPQPVLSPTSAAVPV 823

  Fly   478 LSAMGHV---------GGGGTGTGGSGGGSPASGGPLADRIQPVQ---------PRYLTTPAA-- 522
            .:.|.||         ....|....:....|.|..|.  :.:.:|         ||.::|.|:
Worm   824 PTTMIHVPKPSEIPVQNVATTAAPVAANNVPPSPAPF--KTEDIQTPTLAQNTVPRTISTDASGL 886

  Fly   523 ----QAAVYAASSASSQQAISNAVNDHGPNNFATIRT-----TSIVTKQQKEHMQEEMHEQMSGY 578
                .|::.:.|.|.|...:::......|....|..|     .:..|.:.||       |:....
Worm   887 VINTPASIASPSPAPSATDVASTTAPVTPAPTPTTTTDGGAAAASTTTENKE-------EKRKSN 944

  Fly   579 KRMRREHQAHLVKLEEKCKVDMEAHKTALDKEYDTLLHNFTRDLDRLETKHQ----QDVERRAKQ 639
            ||                ||.||.  ...|:.     .||.....||:|.|:    |......|.
Worm   945 KR----------------KVVMEI--LGCDES-----RNFALVSCRLDTSHKSVTFQFAPGTDKP 986

  Fly   640 TSAAEKKLHKEITLK 654
            .:.|.|.|.::..||
Worm   987 CTIATKLLAEDCLLK 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	73/263 (28%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	72/261 (28%)
wnk-1	NP_001294032.1	STKc_WNK	332..596	CDD:270885	76/278 (27%)
		S_TKc	335..596	CDD:214567	76/278 (27%)
		OSR1_C	622..660	CDD:289010	5/37 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910