DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tao and kin-18

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_001022767.1	Gene:	kin-18 / 175862	WormBaseID:	WBGene00002201	Length:	982	Species:	Caenorhabditis elegans

Alignment Length:	1064	Identity:	399/1064 - (37%)
Similarity:	587/1064 - (55%)	Gaps:	132/1064 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RPGSLKDPEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKW 69
            :||.:|||.||.||:..|||:.::||||||||||||||:|......:.||||||:::|||:.|||
Worm     8 KPGVIKDPSIAALFSNKDPEQRYQDLREIGHGSFGAVYFAYDKKNEQTVAIKKMNFSGKQAVEKW 72

  Fly    70 QDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAAICLGV 134
            .|||||:.||..:.||:.::||.|:|:::|.|||||||:|||:||::|.:|.:.|.||||||...
Worm    73 NDILKEVSFLNTVVHPHIVDYKACFLKDTTCWLVMEYCIGSAADIVDVLRKGMREVEIAAICSQT 137

  Fly   135 LSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPANSFVGTPYWMAPEVILAMDEG 199
            |..|.|||||.|||||||||||||:|:.:|||||||||::..||.:|:|||::||||||||||||
Worm   138 LDALRYLHSLKRIHRDIKAGNILLSDHAIVKLADFGSASLVDPAQTFIGTPFFMAPEVILAMDEG 202

  Fly   200 QYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKND------WSDAFCSFVE 258
            .|..:.|:|||||||||||||:||.|:|||||||||||||:.|||...|      ||..|..|::
Worm   203 HYTDRADIWSLGITCIELAERRPPLFSMNAMSALYHIAQNDPPTLSPIDTSEQPEWSLEFVQFID 267

  Fly   259 LCLKKMPAERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKILMVDTCETE 323
            .||:|...||.|:.:...|.::.|.|....:.|||.|||:.|.||||..|:||:|::.:|  |||
Worm   268 KCLRKPAEERMSAEECFRHPFIQRSRPSDTIQELIQRTKNMVLELDNFQYKKMRKLMYLD--ETE 330

  Fly   324 SAVGD----TDDQQDDHA--------GGD--SSKSNSITSEHSIHSVGVSAASSQSSSSNSIPAA 374
            ...|.    ..|..|.|.        .||  ||:|.|:||..|:.|.|.:..
Worm   331 GKEGSEGNGASDDLDFHGNEANSIGRAGDSASSRSASLTSFRSMQSSGGAGL------------- 382

  Fly   375 AQNHHHIAAHHHQQAASAAVAAAMHHHHHPHQQPPPSWPSGQQGQPVPPGAVSRNSSRHRNRPPL 439
                          ..|.....||.:.|            |..|  ...|:.|..||. |.|||:
Worm   383 --------------LVSTNTTGAMDNVH------------GSSG--YGNGSSSTTSSA-RRRPPI 418

  Fly   440 PNIMHSMNNNVTPTNSASVVPA--------------PAPAPVLPPPISVLPHLSAMGHVGGGGTG 490
            |:.|.|.    |.|:....:|:              |.|:|..|.|.|               ..
Worm   419 PSQMLSS----TSTSGVGTMPSHGSVGASITAIAVNPTPSPSEPIPTS---------------QP 464

  Fly   491 TGGSGGGS---PASGGPLADRIQ-PVQPRYLTTPAAQAAVYAASSASSQQAISNAVNDHGPNNFA 551
            |..|...|   .|...||...|: ||:..::...|.            ::.|:...|    :.||
Worm   465 TSKSESSSILETAHDDPLDTSIRAPVKDLHMPHRAV------------KERIATLQN----HKFA 513

  Fly   552 TIRTTSIVTKQQKEHMQE-EMHEQMSGYKRMRREHQAHLVKLEEKCKVDMEAHKTALDKEYDTLL 615
            |:|:..|:.::|:|:.:| .|:||||.||.:|:.|...|.:.||:|.:|.|..:..:|:|.:.|.
Worm   514 TLRSQRIINQEQEEYTKENNMYEQMSKYKHLRQAHHKELQQFEERCALDREQLRVKMDRELEQLT 578

  Fly   616 HNFTRDLDRLETKHQQDVERRAKQTSAAEKKLHKEITLKQENDRKVYDLNRKKEYKANKERWK-- 678
            ..::::..|:......::::|.|.....|||:.|....:.:...|:|...:.||||.|||..|
Worm   579 TTYSKEKMRVRCSQNNELDKRKKDIEDGEKKMKKTKNSQNQQQMKLYSAQQLKEYKYNKEAQKTR 643

  Fly   679 -RELSMDESTPKRQRDLTLQSQKDNLKQHEAQEEQRMLQAQKQYIELEMRKFKRKRMIMQHEHED 742
             |.|:|..||.:.    .::..|.:|.:.:...|....:..:..:|.|:.:::|:::...|:.|:
Worm   644 LRSLNMPRSTYEN----AMKEVKADLNRVKDARENDFDEKLRAELEDEIVRYRRQQLSNLHQLEE 704

  Fly   743 QQLRDELGKKEQQLQQAHAMLLKHHEKTQELEYRQQKSVHQLREEQINKQHDTELHNQKDYMDRI 807
            |...:::..:|:|:...|.:|.|.||.|::||.:....:|.:::..:..||:.|..:|.:|..|.
Worm   705 QLDDEDVNVQERQMDTRHGLLSKQHEMTRDLEIQHLNELHAMKKRHLETQHEAESASQNEYTQRQ 769

  Fly   808 KKELVRKHAVELRQQPKSLKQKELQIRKQFRETCKTQTKQYKRYKAQVLQTTPKEQQKEVIKQLK 872
            :.||.:|||::.||||:.||.:|.|||||:|:..||||:|:|.|..|::|..||::|||:..:||
Worm   770 QDELRKKHAMQSRQQPRDLKIQEAQIRKQYRQVVKTQTRQFKLYLTQMVQVVPKDEQKELTSRLK 834

  Fly   873 EEKHRKLTLLGEQYEQSIADMFQSQSYKLDESQVIECQRTHEQLEYELEMLTAYQNKNKKQAQEQ 937
            :::.:|:.||..|||..|..|.|.::.||:..|..|.:...|:||.|||.|.|||.|.:...:||
Worm   835 QDQMQKVALLASQYESQIKKMVQDKTVKLESWQEDEQRVLSEKLEKELEELIAYQKKTRATLEEQ 899

  Fly   938 RDRERRELENRVSVRRGLLENKMDAELQQFNQERAERLRMKHEKHTKELEAFDNESIALGFSTLS 1002
            ..:||..||.|:..||.:||.|:..|.:|..:.|..:.....::|::|....:|..:..|
Worm   900 IKKERTALEERIGTRRAMLEQKIIEEREQMGEMRRLKKEQIRDRHSQERHRLENHFVRTG----- 959

  Fly  1003 LIEVSREAYADEEGSLSGSMISLA 1026
              ..||.:.....|..:.|.|.:|
Worm   960 --STSRSSGGIAPGVGNSSSIQMA 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	156/262 (60%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	156/258 (60%)
kin-18	NP_001022767.1	PKc_like	28..291	CDD:304357	156/262 (60%)
kin-18	NP_001022767.1	S_TKc	30..289	CDD:214567	156/258 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166942
Domainoid	1	1.000	330	1.000	Domainoid score	I617
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H27041
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1315
OMA	1	1.010	-	-		QHG48447
OrthoDB	1	1.010	-	-		D277938at33208
OrthoFinder	1	1.000	-	-		FOG0001318
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102967
Panther	1	1.100	-	-	LDO	PTHR48015
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2826
SonicParanoid	1	1.000	-	-		X816
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.840