DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tao and AgaP_AGAP010551

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	XP_314524.4	Gene:	AgaP_AGAP010551 / 1275286	VectorBaseID:	AGAP010551	Length:	1418	Species:	Anopheles gambiae

Alignment Length:	1430	Identity:	289/1430 - (20%)
Similarity:	493/1430 - (34%)	Gaps:	542/1430 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LFNK----HDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDILKEIR 77
            :||.    .||...::.:.|:|.|:||.||.|:...|:::.|.|..:.   :.:|...|.:.||.
Mosquito    23 IFNNIRMDTDPADFWDMIGELGDGAFGKVYKAQNRETKQLAAAKMCTL---EDEENLSDHMVEID 84

  Fly    78 FLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVH-KKPLHEDEIAAICLGVLSGLSYL 141
            .|.::.|||.:.....|..:...|:::|||.|.|.|.|.|. :|||.|.:||.:|..:.:||::|
Mosquito    85 ILSEIKHPNIVGLYEAYSIDDKLWMLIEYCDGGALDSIMVELEKPLTEAQIAYVCKHMCAGLNHL 149

  Fly   142 HSLGRIHRDIKAGNILLTDNGVVKLADFGSAA----IKCPANSFVGTPYWMAPEVILAMDEGQYD 202
            |....||||:||||:|||.:|.|||||||.:|    .....::|:|||||||||::|.
Mosquito   150 HKNKVIHRDLKAGNVLLTMDGGVKLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLC------- 207

  Fly   203 GKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPK-NDWSDAFCSFVELCLKKMPA 266
               :.|             ||...|:.|..|..|.::|.|.|.: :.||..|..|:...|.|.|.
Mosquito   208 ---ETW-------------PPNSEMSPMRVLLKIQKSEPPKLDQPSKWSKHFNDFLARALVKDPQ 256

  Fly   267 ERPSSAKLLTHAYV-----TRP--------RSDTVLLELI------ARTKSAVRELDN------- 305
            :|||:..|:..:::     ::|        ::|.|..||:      .|..:...:||:
Mosquito   257 QRPSTEVLMGLSFISGNLDSKPIKDLLLEYKADVVEEELVDEEAEEPRNSALPLDLDDDSSSLQS 321

  Fly   306 --LNYRKMK--------KILMVDTCET--ESAVGDT---------DDQQ-------DDHAGGDSS 342
              .:.||:|        .||.| .|.:  .::|.||         |.::       :|    |.|
Mosquito   322 QETDKRKLKTYQNLPGCTILTV-VCHSPFPASVPDTPTSLSKSSRDSKESTPVPTTED----DPS 381

  Fly   343 KSNSITSEHSIHSVG--------------------------------------VSAASSQ----- 364
            ||....:..::.:.|                                      |||..:|
Mosquito   382 KSKIGPAPTTVGAPGSAGAAPLEAPPPSVDTKTEMKKSQPAPSPAPPPVVASPVSAEGTQETTIK 446

  Fly   365 --SSSSN-----------------------------------------SIPAAAQNH--HHIAAH 384
              |||||                                         |.|:..:|.  ||....
Mosquito   447 TSSSSSNISGGAVNVPTPVLPVAKEIVPEQPSTGELHAETPVKMITTTSTPSTVRNQLPHHATLM 511

  Fly   385 HHQQAAS---------------------------------------------AAVAAA------- 397
            :...::|                                             ||.|||
Mosquito   512 NTSSSSSTTSITINDAAVLSDPSNSLASNVAQVTVVTSHPPVIIDNSIPLPPAAAAAASSGTSSS 576

  Fly   398 ----------------------------------------------------------MHHHHHP 404
                                                                      :...|||
Mosquito   577 ASSTKSFGSSQLRRSRVISPPGTGAHDEVVIVSNELNKTHVNESSTDDDFQSLDSLENVSPRHHP 641

  Fly   405 HQQPPPSWPSGQQGQPVPPGAVSR----------------------------------------- 428
            .:.|..|...|:        |::|
Mosquito   642 IRTPSQSVAGGR--------AIARKLDESEVLIVSSGYDDRREVLLVDDTNASSPDRDVDAYGDG 698

  Fly   429 ---NSSRHRNRPPLPNIMHSMNNNVTPTNSASVVPAPAPAPVLP------PPISVLPHL------ 478
               |:|.|       |::::.:..:..|:..|||........:.      |.:...||.
Mosquito   699 DVFNASGH-------NLLNNSSKLLLDTSHVSVVTVGEEEIKVKDSSQHHPQLINNPHASREDVS 756

  Fly   479 ----------------SAMGHVGGGGTGTG------------GSGGGSPASGGPLADRIQPVQPR 515
                            |::|.:.|||:...            ||..|....||....|.....
Mosquito   757 IIVNKRKIEKSRISPDSSVGSLEGGGSVRSASTPIHQNHQQHGSAAGGMVIGGNHHQRTGSSG-- 819

  Fly   516 YLTTPAAQAAVYAASSASSQQAISNAVNDHGPNNFATIRTTSIVT---------------KQQKE 565
              |||.|.:|.:.....|..::|:...: |.....|::.....||               |..:.
Mosquito   820 --TTPLAVSAKHHLYDRSDAESIATTTS-HDSREHASVELEEEVTLRRKPMPSLDLDDDKKANRN 881

  Fly   566 HMQEEMH-----------------------------------------------EQMSGYKRMRR 583
            ..:||:|                                               :::...|.:::
Mosquito   882 ISKEELHLQNLKKKTRKRTRKFEIDGVQVTTTTSKVIYSDEDNNKLYDDHLFRKQELRELKMLQK 946

  Fly   584 EHQAHLVKLEEKCKVDMEAHKTALDKEYDTLLHNFTRDLDRLETKHQQDVERRAKQTSAAEKKLH 648
            :.:.....|:.|..:..|..:...::|...|...|..|:|.|..:|:|.||:..:|..|..:...
Mosquito   947 QEKKQFYDLQGKEAIAKEQQEKKFEQERLQLERTFEADMDVLARQHRQTVEKFEQQQEAELRNTS 1011

  Fly   649 KEITLKQENDRKVYDLNRKKEYKANKERWKRELSMDESTPKRQRDLTLQSQKDNLKQHEAQEEQR 713
            |:|..:||.|.|::..:.|:|.:.    .|:|:.:   .||.:|....:.:|..::....:.|:.
Mosquito  1012 KKIRAEQERDLKLFRDSLKQEIRL----LKQEVDL---LPKEKRKDEFRKRKTQMEFEHEEREKS 1069

  Fly   714 MLQAQKQYIELEMRKFKRKRMIMQHEHEDQQLRDE--LGKKEQQLQQAHAMLL----KH-HEKTQ 771
            .|.:..:..||.:|:      |.:...|.....|:  |.:|:..::...|||.    || |:|.|
Mosquito  1070 FLSSLSENHELALRR------ISEIYREKLSATDKGYLQQKQTAMRTREAMLWELEEKHIHDKHQ 1128

  Fly   772 ELEYRQQKSVHQLREEQINKQHDTELHNQKDYMDRIKKELVRKHAVELRQQPKSLKQKELQIRKQ 836
             |..|..|.:..::..|:..:|:.||...|..:.|.::||:::..:|.|..||.::.:.......
Mosquito  1129 -LAKRHVKDICFMQRHQMIIRHEKELDQIKRMITRKEEELLKRQTIERRALPKRIRAERKARDMM 1192

  Fly   837 FRETCKTQTKQYKRYKAQVLQTTPKEQQKEVIKQLKEEKHRKLTLLGEQYEQSIADMFQSQSYKL 901
            |||:.:            :..||..|.:::.:|:.:|::.::       |.|... .|:::..|
Mosquito  1193 FRESLR------------ISMTTDPEVERDKLKKFQEQEKKR-------YNQEQL-RFETKHSK- 1236

  Fly   902 DESQVIECQRTHEQLEYELEMLTAYQNKNKKQAQEQRDRERRELENRVSVRRGLLENKMDAELQQ 966
               |:.|.:.|.|....|||.|   ||:.:||..|....:.||           .:..:..||::
Mosquito  1237 ---QLEELRATSEGSIRELEQL---QNEKRKQLLEHETAKLRE-----------CDEALQKELRE 1284

  Fly   967 FNQERAERLRMKHEKHTKEL-------------EAFD----------NESIALGFSTLSLIEVSR 1008
            :..:...| :...|||...:             ..||          |.:.:|...:|.|:.::|
Mosquito  1285 WKAQLMPR-KQAIEKHLSRMVDEYEDRWGPVDRREFDGDFTVPPELRNRTNSLNTLSLRLLNITR 1348

Fly 1009 1008
Mosquito 1349 1348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	92/267 (34%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	92/258 (36%)
AgaP_AGAP010551	XP_314524.4	PKc_like	31..285	CDD:304357	95/279 (34%)
		S_TKc	37..270	CDD:214567	92/258 (36%)
		PKK	961..1093	CDD:289257	34/144 (24%)
		PKK	1127..1267	CDD:289257	41/167 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910