DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tao and nrk

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	XP_031747384.1	Gene:	nrk / 100486469	XenbaseID:	XB-GENE-952099	Length:	1237	Species:	Xenopus tropicalis

Alignment Length:	762	Identity:	187/762 - (24%)
Similarity:	293/762 - (38%)	Gaps:	266/762 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KDPEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDILK 74
            |..:..||.:..:|..|||.:..:|:|::|.||..|...|.::.|||.|:.|    :|:.::|..
Frog     8 KSLDYIDLASLREPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMNVT----EEEEEEIKL 68

  Fly    75 EIRFLRQL-NHPNTIEYKGCYLRESTA------WLVMEYC-VGSASDIIEVHK-KPLHEDEIAAI 130
            ||..|::. :|.|...|.|.::|:..|      ||||||| .||.:|:::..| ....||.||.|
Frog    69 EINMLKKYSHHRNIATYYGAFVRKGLAGQDDQLWLVMEYCGAGSVTDLVKKTKGNCFKEDWIAYI 133

  Fly   131 CLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFG-SAAIKCP---ANSFVGTPYWMAPE 191
            |..||.||::||:...||||||..|:|||:|..|||.||| ||.:...   .|:|:|||||||||
Frog   134 CREVLRGLAHLHAHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPE 198

  Fly   192 VILAMDE---GQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSDAF 253
            || |.||   ..||.:.|:||||||.||:||..||..:|:.|.||:.|.:|..|.|....||...
Frog   199 VI-ACDENPDSTYDYRSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPKLKSRKWSKKC 262

  Fly   254 CSFVELCLKKMPAERPSSAKLLTHAYV---TRPRSDTVLLELIARTKSAVRELDNLNYRKMKKIL 315
            .:||:.||.|..:.|||:..||.||:|   ...|...::|:            |:|:..:.||
Frog   263 INFVDSCLVKNYSHRPSTDTLLKHAFVRDLQNERHIRIMLK------------DHLDRARKKK-- 313

  Fly   316 MVDTCETESAVGDTDDQQDDHAGGDSSKSNSITSEHSIHSVGVSAASSQSSSSNSIPAAAQNHHH 380
                       |:.|:...:::|.:.....            ::....:.||..::|.
Frog   314 -----------GEKDENGYEYSGSEEEDDE------------LNEDEGEPSSIVNLPG------- 348

  Fly   381 IAAHHHQQAASAAVAAAMHHHHHPHQQPPPSWPSGQQGQPVPPGAVSRNSSRHRNRPPLPNIMHS 445
                          .:.:.......||                      .:::|:.||.|..:..
Frog   349 --------------ESTLRREFLRLQQ----------------------ENKNRSDPPRPQQLQQ 377

  Fly   446 MNNNVTPTNSASVVPAPAPAPVLPPPISVLPHLSAMGHVGGGGTGTGGSGGGSPASGGPLADRIQ 510
            ..                                                         |.|
Frog   378 QQ---------------------------------------------------------LKD--- 382

  Fly   511 PVQPRYLTTPAAQAAVYAASSASSQQAISNAVNDHGPNNFATIRTTSIVTKQQKEHMQEEMHEQM 575
              |.:|.....|:                                     :|::...|:|..:::
Frog   383 --QEKYKMQLQAE-------------------------------------RQKRIEQQKEQRKKL 408

  Fly   576 SGYKRMRREHQAHLVKLEEKCKVDMEAHKTALDKEYDTLLHNFTRDLDRLETKHQQDVERRAKQT 640
            ..|:|..|:.|        ||            :||.........|. :.|.|.::|  |:.
Frog   409 EDYQRRERDLQ--------KC------------QEYQPKWPEMKEDA-KSEGKKRED--RKC--- 447

  Fly   641 SAAEKKLHKEITLKQENDR----KVYDLNRKKEYKANKERWKRELSMDESTPKRQRDLTLQSQKD 701
                          .|.||    ..||.|.:|::    |..|.::...|            .:|.
Frog   448 --------------AEQDRCLFNDAYDKNDRKQH----ENLKHKVDYGE------------KKKT 482

  Fly   702 NLKQHEAQEEQRMLQAQKQYIELEMRKFKRKRMIMQHEHEDQQLRDE 748
            .:.||..:.|:.  |.||:: ...:.|.:.:.:.:||:|:::.|..:
Frog   483 EVSQHGGRPEES--QTQKKF-HRTLPKDQTQLLFLQHDHKEKNLEPQ 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	122/275 (44%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	120/268 (45%)
nrk	XP_031747384.1	STKc_MAP4K4_6_N	8..289	CDD:270806	125/285 (44%)
nrk	XP_031747384.1	CNH	919..1215	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910