DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tao and map4k5

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_001135521.1	Gene:	map4k5 / 100216063	XenbaseID:	XB-GENE-6037447	Length:	861	Species:	Xenopus tropicalis

Alignment Length:	532	Identity:	169/532 - (31%)
Similarity:	242/532 - (45%)	Gaps:	114/532 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPSA--RPGSLKDPEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGK 63
            |.||  ||.       ||:..| :|:..||.::.:|.|::|.||.||...|.|:.|:|.:..
Frog     1 MESAAVRPS-------ADILRK-NPQHDFELVQRVGSGTYGDVYKARNLQTGELAAVKIIKL--- 54

  Fly    64 QSQEKWQDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYC-VGSASDIIEVHKKPLHEDEI 127
            :..:.:..|.:||..:::..|.|.:.|.|.||.....|:.|||| .||..||..| ..||.|.:|
Frog    55 EQGDDFSLIQQEIFMVKECKHANIVAYFGSYLSREKLWICMEYCGGGSLQDIYHV-TGPLTECQI 118

  Fly   128 AAICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPA-----NSFVGTPYW 187
            |.:|...|.||.||||.|::|||||..||||||||.|||||||.|| |..|     .||:|||||
Frog   119 AYMCRETLQGLGYLHSRGKMHRDIKGANILLTDNGDVKLADFGVAA-KITATIAKRKSFIGTPYW 182

  Fly   188 MAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQN--ESPTL-PKNDW 249
            |||||......|.|:...|:|::|||.|||||.:||.|:::.|.||:.::::  :.|.| .|..|
Frog   183 MAPEVAAVEKNGGYNQLCDIWAVGITAIELAELQPPMFDLHPMRALFLMSKSNFQPPKLKEKMKW 247

  Fly   250 SDAFCSFVELCLKKMPAERPSSAKLLTHAYVTRP-RSDTVLLELI-------------------- 293
            |.:|.:||::.|.|.|.:||.:.:||||.:|.:| .|..|..||:
Frog   248 SQSFHNFVKVSLIKNPKKRPPAERLLTHQFVVQPGLSRIVAQELLDKFNNPDSHHHYGEPDDDDP 312

  Fly   294 -------------ARTKSAVRELDNLNYRK------MKKILMVDTCETESAVGDTDDQQDDH--- 336
                         ::...|.|....||:.|      ::|       |||:..|....:::|.
Frog   313 EPLSMVRHTIRSTSKAARAERTASELNFDKLQFEPPLRK-------ETEANEGMGCSRENDFGAQ 370

  Fly   337 -------AGGDSS--------------KSNSITSEHSIHSVGVSAASSQSSSSNSIPAAAQNHH- 379
                   |..||:              :.||...|:...|...|....|..:     .|.|.|.
Frog   371 WISFANGANNDSTMKKAVPPPLPPKPVRMNSCPDENMDDSERSSTIKHQQEN-----RAPQFHRR 430

  Fly   380 -------HIAAHHHQQAASAAVAAAMHHHHH---PHQQPPPSWPSGQQGQPVPPGAVSRN---SS 431
                   |..|..|....|:..:..::...:   .:...|...|.|:.|:|..|....:.   .|
Frog   431 QSSPGCGHQGALSHNVLTSSISSPGLYSSRNCDMGNGDSPVRSPIGEGGKPQLPQKKEKKDIPKS 495

  Fly   432 RHRNRPPLPNIM 443
            .....||.|.::
Frog   496 VINGLPPTPKVL 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	118/265 (45%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	117/261 (45%)
map4k5	NP_001135521.1	STKc_MAP4K5	11..278	CDD:270813	120/272 (44%)
		S_TKc	21..278	CDD:214567	117/261 (45%)
		CNH	525..841	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910