DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tao and taok2b

DIOPT Version :9

Sequence 1:	NP_001188672.1	Gene:	Tao / 32948	FlyBaseID:	FBgn0031030	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	XP_009304676.1	Gene:	taok2b / 100151551	ZFINID:	ZDB-GENE-110603-3	Length:	1247	Species:	Danio rerio

Alignment Length:	1077	Identity:	448/1077 - (41%)
Similarity:	597/1077 - (55%)	Gaps:	203/1077 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPSA-RPGSLKDPEIADLFNKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQ 64
            |||: |.|||||||:|:||.|.||||:|.||||||||||||||:|....|.|:||||||||:|||
Zfish     1 MPSSVRAGSLKDPEVAELFYKEDPEKLFTDLREIGHGSFGAVYFAHDIRTNEVVAIKKMSYSGKQ 65

  Fly    65 SQEKWQDILKEIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAA 129
            |.||||||:||::||::|.||||:||:||||||.|||||||||:|||||::|||||||.|.||||
Zfish    66 SNEKWQDIIKEVKFLQKLRHPNTVEYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAA 130

  Fly   130 ICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPANSFVGTPYWMAPEVIL 194
            |..|.|.||.||||...||||:||||||||:.|.|||.|||||:|..||||||||||||||||||
Zfish   131 ITHGALQGLVYLHSHNMIHRDVKAGNILLTEPGQVKLGDFGSASIVAPANSFVGTPYWMAPEVIL 195

  Fly   195 AMDEGQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSDAFCSFVEL 259
            |||||||||||||||||||||||||||||.||||||||||||||||||.|..|.|||.|.:||:.
Zfish   196 AMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSNHWSDYFRNFVDS 260

  Fly   260 CLKKMPAERPSSAKLLTHAYVTRPRSDTVLLELIARTKSAVRELDNLNYRKMKKILMVDTC---- 320
            ||:|:..:||:|..||.|.::.|.|..||:::||||||.||||||||.||||||||..:|.
Zfish   261 CLQKISQDRPTSDVLLKHHFLCRERPVTVVMDLIARTKDAVRELDNLQYRKMKKILFQETHNGPA 325

  Fly   321 -----ETESAVGDTDDQQDDHAGGDSSKSNSITSEHSIHSVGVSAASSQSSSSNSIPAAAQNHHH 380
                 |.||.|....:|.....|    ..||:.|.||:.|:.:| |||||||.||:...:.:...
Zfish   326 TEGTEEEESCVFQDVEQYMLRTG----TVNSMESSHSLPSMSIS-ASSQSSSVNSLADGSDDSGE 385

  Fly   381 IAAHHHQQAASAAVAAAMHHHHHPHQQPPPSWPSGQQGQPVPPGAVSRNSSRHRNRPPLPNIMHS 445
            :|..                               |:|:    ..|:.|||          ::|
Zfish   386 MAMM-------------------------------QEGE----HTVTSNSS----------VLH- 404

  Fly   446 MNNNVTPTNSASVVPAPAPAPVLPPPISVLPHLSAMGHVGGGGTGTGGSGGGSPASGGPLADRI- 509
                                             .|:.|                       |.|
Zfish   405 ---------------------------------KALNH-----------------------DNIY 413

  Fly   510 -QPVQPRYLTTPAAQAAVYAASSASSQQAISNAVNDHGPNNFATIRTTSIVTKQQKEHMQ-EEMH 572
             .|.||.            ..|....||..|......|.::||||||.|:||:|.:||.| ..:.
Zfish   414 DDPYQPE------------MDSQQQQQQGPSGGRRRRGRDHFATIRTASLVTRQIQEHEQGSALR 466

  Fly   573 EQMSGYKRMRREHQAHLVKLEEKCKVDMEAHKTALDKEYDTLLHNFTRDLDRLETKHQQDVERRA 637
            |||||||||||:||..|:.||.|.|.:|:.|:..||||.:|..:||..:.|:|..|||..:|:..
Zfish   467 EQMSGYKRMRRQHQKQLMALENKLKAEMDEHQLRLDKELETQRNNFGSEADKLSKKHQAILEKET 531

  Fly   638 KQTSAAEKKLHKEITLKQENDRKVYDLNRKKEYKANKERWKRELSMDESTPKRQRDLTLQSQKDN 702
            |...|.|||..:.|..:|:.:......::|:.|:..||:.|.||:.::|||||::...|..||:.
Zfish   532 KGAIAEEKKFQQHILGQQKKELTSLLESQKRHYRQRKEQLKEELNENQSTPKREKQEWLVQQKEC 596

  Fly   703 LKQHEAQEEQRMLQAQKQYIELEMRKFKRKRMIMQHEHEDQQLRDELGKKEQQLQQAHAMLLKHH 767
            |:|.:|:||..:|:.|:||.||:.|::|||.::.:|..|...||::|.||:.......||||:||
Zfish   597 LQQVQAEEEAGLLRRQRQYYELQGRQYKRKMLLSRHNLEQDLLREDLNKKQTLKDLECAMLLRHH 661

  Fly   768 EKTQELEYRQQKSVHQLREEQINKQHDTELHNQKDYMDRIKKELVRKHAVELRQQPKSLKQKELQ 832
            |.|||||:||...|.:.|.:.|..||.|||.||.:|..|.::||.:|||||:|||||||:..:..
Zfish   662 ESTQELEFRQLALVQRTRADLIRTQHQTELTNQMEYNKRREQELRQKHAVEVRQQPKSLRVSDSD 726

  Fly   833 IRKQFRETCKTQTKQYKRYKAQVLQTTPKEQQKE--------------VIKQLKEEKHRKLTLLG 883
            |.:...|......:..:          |::::|.              .:::..|::.|::.:|.
Zfish   727 ITENTTEGAGLDIEGVE----------PQDEEKRDGEKIDGDEMQPLGAVEETSEQEMREVNVLE 781

  Fly   884 EQYEQSIADMFQSQSYKLDESQVIECQRTHEQLEYELEMLTAYQNKNKKQAQEQRDRERRELENR 948
            |.         .::....|:..||:.:...|:|....:.:....:|:.|.|.|::
Zfish   782 EN---------DTEETLTDQCDVIDSEGKVEELAESADNVNESADKSPKIADEEQ---------- 827

  Fly   949 VSVRRGLLENKMDAELQQFNQERAERLRMKHEKHTKELEAFDNESIALGFST------------- 1000
                   :|:|:|.:|:|     .|.|:...|..:...|  ::..:|.|..:
Zfish   828 -------VEDKIDNDLRQ-----VEGLQWDGESESDSAE--EDRGVADGCPSELIPGPSFERRPL 878

  Fly  1001 -LSLIEVSREAYADEEGSLSGSMISLAHSNSSTSFPA 1036
             ..|.|:|...:.|....|....:.:..|.||:|.|:
Zfish   879 ERDLDELSEFYFPDTLEELEPPPVYIPPSPSSSSQPS 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tao	NP_001188672.1	STKc_TAO	25..282	CDD:270784	193/256 (75%)
Tao	NP_001188672.1	S_TKc	27..280	CDD:214567	192/252 (76%)
taok2b	XP_009304676.1	PKc_like	6..318	CDD:304357	234/311 (75%)
taok2b	XP_009304676.1	S_TKc	28..281	CDD:214567	192/252 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	525	1.000	Domainoid score	I276
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	970	1.000	Inparanoid score	I302
OMA	1	1.010	-	-		QHG48447
OrthoDB	1	1.010	-	-		D277938at33208
OrthoFinder	1	1.000	-	-		FOG0001318
OrthoInspector	1	1.000	-	-		otm24956
orthoMCL	1	0.900	-	-		OOG6_102967
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X816
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980