Protein Alignment car and VPS45

DIOPT Version :9

• Sequence 1: NP_001259707.1
• Gene: car / 32947
• FlyBaseID: FBgn0000257
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_011420.3
• Gene: VPS45 / 852785
• SGDID: S000003063
• Length: 577
• Species: Saccharomyces cerevisiae
• Alignment Length: 637
• Identity: 133/637 - (20%)
• Similarity: 258/637 - (40%)
• Gaps: 148/637 - (23%)

  Fly    36 KVIVLDETMIGPLDL-VTRPKLFADRGIRLLALKPELHLPREVAN-----------VVYVMRPRV 88
            ||::||:.....:.| .|:.:|          ||.|::|...:.|           :||| :|
Yeast    33 KVLLLDKNTTPTISLCATQSEL----------LKHEIYLVERIENEQREVSRHLRCLVYV-KP-- 84

  Fly    89 ALMEQLAAHVKAGGRAAAGRQYHILFAPRRSCLCVSQLE---VSGVLGSFGNIEELAWNYLPLDV 150
              .|:...|:....|.....:|.|.|:   :.:..||||   .|..|.:...:||:..::..|:.
Yeast    85 --TEETLQHLLRELRNPRYGEYQIFFS---NIVSKSQLERLAESDDLEAVTKVEEIFQDFFILNQ 144

  Fly   151 DLVSMEM-PNAFRDVSVDGDTSSLYQAAVGLVQLQRLYGRIPKIYGKGEFAHRVWEH-AK----Q 209
            ||.|.:: |..|....:......|.:....||.:.......|.|..:|  |.::.|. ||    :
Yeast   145 DLFSFDLQPREFLSNKLVWSEGGLTKCTNSLVSVLLSLKIKPDIRYEG--ASKICERLAKEVSYE 207

  Fly   210 LGRDERTLYNGDKGVVDQ---LILLDRSIDLLSPLATQLTYEGLIDEFYGIRQNKLTLPAENFPS 271
            :|::|||.:  |..|:|.   |::|||:.|.::||....||:.:|:|:.||::|.:.|
Yeast   208 IGKNERTFF--DFPVMDSTPVLLILDRNTDPITPLLQPWTYQSMINEYIGIKRNIVDL------- 263

  Fly   272 DGALPGGGGSGPRVEESQSLLGDTEKKTILLHSGEQ--LYAELRNKHFNEVTKLLARKAREIHVQ 334
                    ...||:::      |.||.|:   |.:|  .:.:....:|.|:...:.:.......:
Yeast   264 --------SKVPRIDK------DLEKVTL---SSKQDAFFRDTMYLNFGELGDKVKQYVTTYKDK 311

  Fly   335 MHATSQDKSVQEIKSFVENLLPQLMAQKKATSEHTAIAGLLHEQVNAVRFADDLAAEQEFMVCAD 399
            ....||..|:::||:|:|. .|:........::|.||.|.|..|:......:....||      :
Yeast   312 TQTNSQINSIEDIKNFIEK-YPEFRKLSGNVAKHMAIVGELDRQLKIKNIWEISEIEQ------N 369

  Fly   400 IDKPSAYIEDLIACRVELNRVLRLICMQCHAASGFKEKLLNHYKRELVHVYGLEVLLTISNLEKS 464
            :....|..||.    .:|.::|:            .|.:..:||.:|..:|.
Yeast   370 LSAHDANEEDF----SDLIKLLQ------------NEAVDKYYKLKLACIYS------------- 405

  Fly   465 GLLHLQTESRAYSVLRKTLHLTVDDNVEIEPKDISYVHSFYAPLTA--RIVEHS------LKPLG 521
              |:.||.|.....|.:.|      :.::.|:|:::.|.|.:..:.  ::.:.:      |..|.
Yeast   406 --LNNQTSSDKIRQLVEIL------SQQLPPEDVNFFHKFKSLFSRQDKMTQSNHDKDDILTELA 462

  Fly   522 WQTLKSQINNLPGPTFEDFQAQLVGIGGRHTVTTVSEGSLL---------------------NVP 565
             :...|::|:........:...:..|..  .:|.:|:.:|.                     ::|
Yeast   463 -RRFNSRMNSKSNTAENVYMQHIPEISS--LLTDLSKNALFRDRFKEIDTQGHRVIGNQQSKDIP 524

  Fly   566 RVVLVCFVGGCTFAEIAALRFLAAQEDNNVEFLIATTKVVNKHSFLDSLMSS 617
            :.|::..:||.|:.|...:.......:|.:..::..|.:::...::||:.|:
Yeast   525 QDVILFVIGGVTYEEARLVHDFNGTMNNRMRVVLGGTSILSTKEYMDSIRSA 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
car	NP_001259707.1	Sec1	36..606	CDD:279352	130/624 (21%)
VPS45	NP_011420.3	SEC1	3..577	CDD:227487	133/637 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810