Protein Alignment car and STXBP3

DIOPT Version :9

• Sequence 1: NP_001259707.1
• Gene: car / 32947
• FlyBaseID: FBgn0000257
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_009200.2
• Gene: STXBP3 / 6814
• HGNCID: 11446
• Length: 592
• Species: Homo sapiens
• Alignment Length: 652
• Identity: 114/652 - (17%)
• Similarity: 230/652 - (35%)
• Gaps: 174/652 - (26%)

  Fly    33 EGS-KVIVLDETMIGPLDLVTRPKLFADRGIRLLALKPELHLPREVANVVYVMRPRV----ALME 92
            ||. |:::|||.....|....:.....:.||.::....:...|......:|.:.|..    ..:.
Human    29 EGEWKIMLLDEFTTKLLASCCKMTDLLEEGITVVENIYKNREPVRQMKALYFITPTSKSVDCFLH 93

  Fly    93 QLAAHVKAGGRAAAGRQYHILFAP-------RRSCLCVSQLEVSGVLGSFGNIEELAWNYLPLDV 150
            ..|:  |:..:..|...|...|.|       :.||           ..|....:|:..:::|.:.
Human    94 DFAS--KSENKYKAAYIYFTDFCPDNLFNKIKASC-----------SKSIRRCKEINISFIPHES 145

  Fly   151 DLVSMEMPNAF------RDVSVDGDTSSLYQAAVGLVQLQRLYGRIPKIYGKGEFAHRVWEHAKQ 209
            .:.::::|:||      ...:..|..:.:...|..:|.:.......|.:    .:..:..::|.:
Human   146 QVYTLDVPDAFYYCYSPDPGNAKGKDAIMETMADQIVTVCATLDENPGV----RYKSKPLDNASK 206

  Fly   210 LGR------------DERTLYNGDKGVVDQLILLDRSIDLLSPLATQLTYEGLIDEFYGIRQNKL 262
            |.:            ||::|..|.  ...||:::||..|.:|.:..:||::.:..:.
Human   207 LAQLVEKKLEDYYKIDEKSLIKGK--THSQLLIIDRGFDPVSTVLHELTFQAMAYDL-------- 261

  Fly   263 TLPAEN----FPSDGALPGGGGSGPRVEESQSLLGDTEKKTILLHSGEQLYAELRNKHFNEVTKL 323
             ||.||    :.:||                      ::|..:|...:.|:..:|::|...|.:.
Human   262 -LPIENDTYKYKTDG----------------------KEKEAILEEEDDLWVRIRHRHIAVVLEE 303

  Fly   324 LARKAREIHVQMHATSQDKSVQEIKSFVENLLPQLMAQ----KKATSEHTAIAGLLHEQVNAVRF 384
            :.:..:||.....||....|:        :.|.|||.:    :|..::......|..:.:|..:.
Human   304 IPKLMKEISSTKKATEGKTSL--------SALTQLMKKMPHFRKQITKQVVHLNLAEDCMNKFKL 360

  Fly   385 ADDLAAEQEFMVCADIDKPSAYIED--LIACRVELNR------VLRLICMQCHAASGFKEKLLNH 441
            ..:...:.|..:....|.....::|  .:...|.||:      .:|.|.:...:.:|..|:.|:.
Human   361 NIEKLCKTEQDLALGTDAEGQKVKDSMRVLLPVLLNKNHDNCDKIRAILLYIFSINGTTEENLDR 425

  Fly   442 YKRELVHVYGLEVLLTISNLEKSGLLHLQTESRAYSVLRKTLHLTVDDNVEIEP---------KD 497
                           .|.|::      ::.||   .::|...:|    .|.|.|         ||
Human   426 ---------------LIQNVK------IENES---DMIRNWSYL----GVPIVPQSQQGKPLRKD 462

  Fly   498 ISYVHSF----YAPLTARIVEHSLKPLGWQTLKSQINNLPGPTFEDFQAQLVGIGGRHTVTTVSE 558
            .|...:|    :.|....|:|        ..:.:::::...|......|...|.|.
Human   463 RSAEETFQLSRWTPFIKDIME--------DAIDNRLDSKEWPYCSQCPAVWNGSGA--------- 510

  Fly   559 GSLLNVPRV-----------VLVCFVGGCTFAEIAALRFLAAQEDNNVEFLIATTKVVNKHSFLD 612
            .|....||.           ::|..:||.|::|:.. .:..:|...:.|.:|.:|.|:.....||
Human   511 VSARQKPRANYLEDRKNGSKLIVFVIGGITYSEVRC-AYEVSQAHKSCEVIIGSTHVLTPKKLLD 574

  Fly   613 SL 614
            .:
Human   575 DI 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
car	NP_001259707.1	Sec1	36..606	CDD:279352	110/638 (17%)
STXBP3	NP_009200.2	Mediates interaction with DOC2B. /evidence=ECO:0000250	1..255		44/244 (18%)
		Sec1	33..569	CDD:307231	110/639 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810