DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment car and Vps33a

DIOPT Version :9

Sequence 1:	NP_001259707.1	Gene:	car / 32947	FlyBaseID:	FBgn0000257	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_075250.2	Gene:	Vps33a / 65081	RGDID:	620643	Length:	597	Species:	Rattus norvegicus

Alignment Length:	625	Identity:	276/625 - (44%)
Similarity:	383/625 - (61%)	Gaps:	42/625 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFPHLKGHGQRVNLQLLQEAACRELLQQLDRIEGSKVIVLDETMIGPLDLVTR---------PKL 56
            |..|| .:| ||||.:|:||..|||.:.||:..|||.||.||.:.||..|:.:         .|:
  Rat     1 MAAHL-SYG-RVNLNVLREAVRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKM 63

  Fly    57 FADRGIRLLALKPELHLPREVANVVYVMRPRVALMEQLAAHVKAGGRAAAGRQYHILFAPRRSCL 121
            |..:|.||.|        .:|.|:::::|||:.||:.:|.:|.:..|....|.:||||.||||.|
  Rat    64 FTLKGSRLPA--------ADVKNIIFLVRPRLELMDMIAENVLSEDRRGPTRDFHILFVPRRSLL 120

  Fly   122 CVSQLEVSGVLGSFGNIEELAWNYLPLDVDLVSMEMPNAFRDVSVDGDTSSLYQAAVGLVQLQRL 186
            |..:|:..||||||...||.:.:.:|.|.||:|||..:||::..::||.:|||.||.||:.||.|
  Rat   121 CEQRLKDLGVLGSFIYREEYSLDLIPFDGDLLSMESESAFKECYLEGDQTSLYHAAKGLMTLQAL 185

  Fly   187 YGRIPKIYGKGEFAHRVWEHAKQLGRDERTLYNGDKGVVDQLILLDRSIDLLSPLATQLTYEGLI 251
            ||.||:|:||||.|.:|.....::.|:.....|....|.|.|:||||::|||:|||:||||||||
  Rat   186 YGTIPQIFGKGECARQVANMMVRMKREFTGSQNSVFPVFDNLLLLDRNVDLLTPLASQLTYEGLI 250

  Fly   252 DEFYGIRQNKLTLPAENFPSDGALPGGGGSGPRVEESQSLLGDTEKKTILLHSGEQLYAELRNKH 316
            ||.|||:.:.:.||.|.|.......|||...|           ||.|.:.|:|.|:||||:|:|:
  Rat   251 DEIYGIQNSYVKLPPEKFAPKKQGGGGGKDLP-----------TEAKKLQLNSAEELYAEIRDKN 304

  Fly   317 FNEVTKLLARKAREIHVQMHATSQDKSVQEIKSFVENLLPQLMAQKKATSEHTAIAGLLHEQVNA 381
            ||.|..:|::||:.|..........|:|.|||.||.. ||.:.|.:.:.:.||:||.|:.:...:
  Rat   305 FNAVGSVLSKKAKIISAAFEERHNAKTVGEIKQFVSQ-LPHMQAARGSLANHTSIAELIKDVTTS 368

  Fly   382 VRFADDLAAEQEFMVCADIDKPSAYIEDLIACRVELNRVLRLICMQCHAASGFKEKLLNHYKREL 446
            ..|.|.|..|||||...|.||.:.||||.||.:..|.:||||:|:|....||.|:|:|::||||:
  Rat   369 EDFFDKLTVEQEFMSGIDTDKVNNYIEDCIAQKHPLIKVLRLVCLQSVCNSGLKQKVLDYYKREI 433

  Fly   447 VHVYGLEVLLTISNLEKSGLLHLQTESR-AYSVLRKTLHLTVDDNVEIEPKDISYVHSFYAPLTA 510
            :..||.|.:||::||||:|||..||..| .|..:||||.|.:||..|..|.|||||:|.||||:.
  Rat   434 LQTYGYEHILTLNNLEKAGLLKAQTGGRNNYPTIRKTLRLWMDDVNEQNPTDISYVYSGYAPLSV 498

  Fly   511 RIVEHSLKPLGWQTLKSQINNLPGPTFEDFQAQLVGIGGRHTVTTVSEGSLLNVPRVVLVCFVGG 575
            |:.:...:| ||::::..:..||||.||:.|....|:..:.     ..|.    .||.||.|:||
  Rat   499 RLAQLLSRP-GWRSIEEVLRILPGPHFEERQPLPTGLQKKR-----QPGE----NRVTLVFFLGG 553

  Fly   576 CTFAEIAALRFLAAQEDNNVEFLIATTKVVNKHSFLDSLM 615
            .|||||||||||:..||...|::|||||::|..|:|::||
  Rat   554 VTFAEIAALRFLSQLEDGGTEYVIATTKLINGSSWLEALM 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
car	NP_001259707.1	Sec1	36..606	CDD:279352	253/579 (44%)
Vps33a	NP_075250.2	Sec1	34..585	CDD:395791	253/580 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334249
Domainoid	1	1.000	433	1.000	Domainoid score	I561
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11294
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1504
OMA	1	1.010	-	-		QHG53951
OrthoDB	1	1.010	-	-		D406738at2759
OrthoFinder	1	1.000	-	-		FOG0002117
OrthoInspector	1	1.000	-	-		oto96269
orthoMCL	1	0.900	-	-		OOG6_101460
Panther	1	1.100	-	-	LDO	PTHR11679
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1571
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910