DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment car and Vps45

DIOPT Version :9

Sequence 1:	NP_001259707.1	Gene:	car / 32947	FlyBaseID:	FBgn0000257	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_742069.1	Gene:	Vps45 / 64516	RGDID:	621267	Length:	570	Species:	Rattus norvegicus

Alignment Length:	642	Identity:	133/642 - (20%)
Similarity:	242/642 - (37%)	Gaps:	128/642 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ACRELLQQL--DRIEGSKVIVLDETMIGPLDLV-TRPKLFADRGIRLLALKPELHL-------PR 75
            |.::.:.::  |...|.||:::|:...|.:.:| |:.::          |:.|::|       .|
  Rat     6 AVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEI----------LQKEVYLFERIDSQNR 60

  Fly    76 EV---ANVVYVMRPRVALMEQLAAHVKAGGRAAAGRQYHILFAPRRSCLCVSQLEVSGVLGSFGN 137
            |:   ...:..:||....::.|...:    |......|.|.|:...|...|..|..:........
  Rat    61 EIMKHLKAICFLRPTKENVDSLIQEL----RRPKYSIYFIYFSNVISKSDVKSLAEADEQEVVAE 121

  Fly   138 IEELAWNYLPLDVDLVSMEMPNAFRDVSVDGDTSSLYQAAVGLVQLQRLYGRIPKIYGK--GEFA 200
            ::|...:|:.::..|.|:.:....:  ..:.|.:.|.:...||..|.....:.|.|..:  .|.|
  Rat   122 VQEFYGDYIAVNPHLFSLNILGCCQ--GRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLSSEAA 184

  Fly   201 HRVWEHAKQLGRDERTLYNGDKGVVDQLIL-LDRSIDLLSPLATQLTYEGLIDEFYGIRQNKLTL 264
            .|:.|..||:...|..|:...:..|..|:| |||..|.::||..|.||:.::.|..||..|::.|
  Rat   185 KRLGECVKQVISKEYELFEFRRTEVPPLLLILDRCDDAITPLLNQWTYQAMVHELLGINNNRIDL 249

  Fly   265 PAENFPSDGALPGGGGSGPRVEESQSLLGDTEKKTILLHSGEQLYAELRNKHFNEVTKLLARKAR 329
                    ..:||              :....::.:|....::.||.....:|.|:...:.....
  Rat   250 --------SRVPG--------------ISKDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLME 292

  Fly   330 EIHVQMHATSQD-KSVQEIKSFVENLLPQLMAQKKATSEHTAIAGLLHEQVNAVRFADDLAAEQE 393
            :...:.....|. :|:.::|:|||| .||........|:|..:.|.|...|:.....:....|||
  Rat   293 DFQKKRPKEQQKLESIADMKAFVEN-YPQFKKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQE 356

  Fly   394 FMVCADIDKPSAYIEDLIACRVELNRVLRLICMQCHAASGFKEKLLNHYKRELVHVYGLEVLLTI 458
             :.|.: |..||           |..|.||:         ...|:.......||.:|.|......
  Rat   357 -LACQN-DHSSA-----------LQNVKRLL---------QNPKVTEFDAVRLVMLYALHYERHS 399

  Fly   459 SNLEKSGLLHLQTESRAYSVLRKTLHLTVD---------------DNVEIEP------KDISYVH 502
            ||.....::.|:::..| ...||.:...|:               |.|.|..      |.:..|:
  Rat   400 SNSLPGLIVDLRSKGVA-EKYRKLVSAVVEYGGKRVRGSDLFSPKDAVAITKQFLKGLKGVENVY 463

  Fly   503 SFYAPLTARIVEHSLKPLGWQTLKSQINNLPGPTFEDFQAQLVGIGGRHTVTTVSEGSLLNVPRV 567
            :.:.|.....::|.:|    ..||..:....||:                       :|.:.|:.
  Rat   464 TQHQPFLHETLDHLIK----GKLKENLYPYLGPS-----------------------TLRDRPQD 501

  Fly   568 VLVCFVGGCTFAEIAALRFLAAQEDNNVEFLIATTKVVNKHSFLDSLMSSXGRRLSR 624
            ::|..:||.|:.| |...:...:....|..::..|.:.|..|||:.:::| ....||
  Rat   502 IIVFVIGGATYEE-ALTVYNLNRTTPGVRIVLGGTTIHNTKSFLEEVLASGLHSRSR 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
car	NP_001259707.1	Sec1	36..606	CDD:279352	123/605 (20%)
Vps45	NP_742069.1	Sec1	23..539	CDD:395791	123/605 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810