Protein Alignment car and vps33

DIOPT Version :9

• Sequence 1: NP_001259707.1
• Gene: car / 32947
• FlyBaseID: FBgn0000257
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_596210.1
• Gene: vps33 / 2539880
• PomBaseID: SPBC1703.15c
• Length: 592
• Species: Schizosaccharomyces pombe
• Alignment Length: 618
• Identity: 169/618 - (27%)
• Similarity: 291/618 - (47%)
• Gaps: 65/618 - (10%)

  Fly    17 LQEAACRELLQQLDRIEGSKVIVLDETMIGPLDLVTRPKLFADRGIRLLALKPELH-----LPRE 76
            ::|.|..:||..:|.:.|.|.::|:..:.|.|..:.......:.||      |:::     :|.:
pombe     5 VKEKATFKLLDLIDSVTGKKSLLLERDLSGILGQIVTTNTLQEHGI------PQVYWFNENIPND 63

  Fly    77 V-ANVVYVMRPRVALMEQLAAHVKAGGRAAAGRQYHILFAPRRSCLCVSQLEVSGVLGSFGNIEE 140
            : ...:|:.||.....:.:|.||:...|.....:..::..|..:.|..:.|:..||   ||.:..
pombe    64 IEKKTIYLCRPTYENAKLVATHVRQFQRDMLRIESTVIVLPTSNILFETVLQEEGV---FGELLV 125

  Fly   141 LAW--NYLPLDVDLVSMEM-PNAFRDVSVDGDTSSLYQAAVGLVQLQRLYGRIPKIYGKGEFAHR 202
            ..|  :.:|||.||:|:|: |....:       |.|.::...|:..:|.:||.|::.|:|.:|.:
pombe   126 TEWPLHAVPLDKDLLSLELGPEKLEE-------SLLQRSTDALIDFERTHGRFPRVSGRGPYAAK 183

  Fly   203 VWEHAKQLGRDERTLYNGD-----KGVVDQLILLDRSIDLLSPLATQLTYEGLIDEFYGIRQNKL 262
            :.|..::..::|.|:..|.     ..:.|.::|:|||:|.::|..|||||.|.:||..||:|..:
pombe   184 MLELLEKTYQEEATINFGKVEGEISALYDSVLLVDRSLDRITPFLTQLTYFGFLDEILGIQQMNV 248

  Fly   263 TLPAENFPSDGALPGGGGSGPRVEESQSLLGDTEKKTILLHSGEQLYAELRNKHFNEVTKLLARK 327
            .||:.....:.|    ..:||.            ||..|..|..|:..|:|:.:||.:...|::.
pombe   249 KLPSSLVNRNEA----SNTGPM------------KKFSLSSSSSQITKEIRDINFNCIGPYLSKI 297

  Fly   328 AREIHVQMHATSQDKSVQEIKSFVENLLPQLMAQKKATSEHTAIAGLLHEQVNAVRFADDLAAEQ 392
            ||::........|.|:|.:|:.||.. |..|.::..:.:.||.:|..|.:......|...|..:.
pombe   298 ARKLSSDFEGRRQAKTVNQIRDFVSK-LGSLQSEHTSLNIHTGLAETLVQHTKNNYFQKLLQLQH 361

  Fly   393 EFMVCADIDKPSAYIEDLIACRVELNRVLRLICMQCHAASGFKEKLLNHYKRELVHVYGLEVLLT 457
            ..:..||.......::::|.....:..|.|::|:.....:|.:.|.::||:||:...||...|||
pombe   362 LLVSHADSFTQFNLLDEIIYAEAPVEEVFRVLCLASITTNGLRRKDIDHYRREITQTYGYYHLLT 426

  Fly   458 ISNLEKSGLLHLQ-------TESRAYSVLRKTLHLTVDDNVEIEPKDISYVHSFYAPLTARIVEH 515
            ...|..:|||.|:       .:|.:||....|..|..|:..|..|:||:|.:|.|.||:..|...
pombe   427 FQALIDAGLLRLRQSTNISLQKSLSYSTWLNTYPLVKDEVDEQNPEDIAYTYSGYGPLSVHIAYD 491

  Fly   516 SLKPLGWQTLKSQINNLPGPTFEDFQAQLVGIGGRHTVTTVSEGSLLNVP--RVVLVCFVGGCTF 578
            .||....:....::.|:||...:.:......:..::..|        |||  |.|||.|:||||:
pombe   492 ILKGRDNEEKILKLQNMPGTYVDKWTLDQEKVMPKNLKT--------NVPGKRRVLVFFIGGCTY 548

  Fly   579 AEIAALRFLAAQEDNNVEFLIATTKVVNKHSFL 611
            .|:||.|.|..:|| ..||...||.:|...|.:
pombe   549 TELAAFRLLQEKED-LYEFTFMTTGMVTGSSLI 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
car	NP_001259707.1	Sec1	36..606	CDD:279352	161/592 (27%)
vps33	NP_596210.1	SEC1	2..591	CDD:227487	169/618 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	203	1.000	Domainoid score	I635
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11294
Inparanoid	1	1.050	214	1.000	Inparanoid score	I934
OMA	1	1.010	-	-		QHG53951
OrthoFinder	1	1.000	-	-		FOG0002117
OrthoInspector	1	1.000	-	-		oto100831
orthoMCL	1	0.900	-	-		OOG6_101460
Panther	1	1.100	-	-	O	PTHR11679
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1650
SonicParanoid	1	1.000	-	-		X1571
TreeFam	1	0.960	-	-
	14	13.860