Protein Alignment car and SCFD1

DIOPT Version :9

• Sequence 1: NP_001259707.1
• Gene: car / 32947
• FlyBaseID: FBgn0000257
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_057190.2
• Gene: SCFD1 / 23256
• HGNCID: 20726
• Length: 642
• Species: Homo sapiens
• Alignment Length: 720
• Identity: 141/720 - (19%)
• Similarity: 262/720 - (36%)
• Gaps: 212/720 - (29%)

  Fly    18 QEAACRELLQ-QLDRIEGS------KVIVLD---ETMIGPLDLVTRPKLFADRGIRLLALKPELH 72
            |..|.:.:|. .:..|:.|      ||::.|   :.:|.||..|   |...|.||.|..|   ||
Human    19 QTVALKRMLNFNVPHIKNSTGEPVWKVLIYDRFGQDIISPLLSV---KELRDMGITLHLL---LH 77

  Fly    73 LPRE-VANV--VYVMRPRVALMEQLAAHVKAGGRAAAGRQYHILFAPRRSCLCVSQLE------- 127
            ..|: :.:|  ||.:.|....::::...:    |......|::.|.   |.:..|:||
Human    78 SDRDPIPDVPAVYFVMPTEENIDRMCQDL----RNQLYESYYLNFI---SAISRSKLEDIANAAL 135

  Fly   128 VSGVLGSFGNIEELAWNYLPLDVDLVSMEMPN----AFRDVS------------VDGDTSSLYQA 176
            .:..:.....:.:...|::.|:.|:..:...|    ::|.::            :|....||:..
Human   136 AASAVTQVAKVFDQYLNFITLEDDMFVLCNQNKELVSYRAINRPDITDTEMETVMDTIVDSLFCF 200

  Fly   177 AVGLVQLQRLYGRIPKI-YGKGEFAHRVWEHAKQLG-------RDER-TLYNGDKGVVDQ----- 227
            .|.|       |.:|.| ..:|..|..|   |.:|.       ||.| :|:.||.....|
Human   201 FVTL-------GAVPIIRCSRGTAAEMV---AVKLDKKLRENLRDARNSLFTGDTLGAGQFSFQR 255

  Fly   228 --LILLDRSIDLLSPLATQLTYEGLIDEFYGIRQNKLTLP----AENFPSDGALPGGGGSGPRVE 286
              |:|:||:|||.:||....||:.|:.:......|::.|.    .||.|:        |:.|:.:
Human   256 PLLVLVDRNIDLATPLHHTWTYQALVHDVLDFHLNRVNLEESSGVENSPA--------GARPKRK 312

  Fly   287 ESQSLLGDTEKKTILLHSGEQLYAELRNKHFNEVTKLLARKAREIHVQMHATSQDKSVQEIKSFV 351
                     .||:..|...::.:.:.:...|.||.:.:.::......|.....:.||:..::...
Human   313 ---------NKKSYDLTPVDKFWQKHKGSPFPEVAESVQQELESYRAQEDEVKRLKSIMGLEGED 368

  Fly   352 E-----------------NLLPQLMAQKKATSEHTAIAGLLHEQVNAVRFADDLAAEQEFMVCAD 399
            |                 :.||:|:.:|:....||.:|..:.|.:.|.:.......|::.|....
Human   369 EGAISMLSDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKARKLDVYFEYEEKIMSKTT 433

  Fly   400 IDKPSAYIEDLIACRVELNRVLRLICMQCHAASGFKEKLLNHYKRELVHVYGLEVLLTISNLEKS 464
            :||.   :.|:|:                ...:|..|..:..:   |::....:...:.::||:
Human   434 LDKS---LLDIIS----------------DPDAGTPEDKMRLF---LIYYISTQQAPSEADLEQ- 475

  Fly   465 GLLHLQTESRAYSVLRKTLHLTVDDNVEIEPKDISYVHSF-----YAPLTARIVEHSLKPLGWQT 524
                          .:|.|   .|....:.|  :.|:..:     .|...|.....:.||:|..:
Human   476 --------------YKKAL---TDAGCNLNP--LQYIKQWKAFTKMASAPASYGSTTTKPMGLLS 521

  Fly   525 ------------------LKSQINNLP-------------GPTFEDFQAQLVGIGGRHTVTTVSE 558
                              ||.|  |||             .|..:|:         |:....:..
Human   522 RVMNTGSQFVMEGVKNLVLKQQ--NLPVTRILDNLMEMKSNPETDDY---------RYFDPKMLR 575

  Fly   559 GSLLNVPR------VVLVCFVGGCTFAEIAAL-RFLAAQEDNNVEFLIATTKVVNKHSFLDSLMS 616
            |:..:|||      ..:|..|||..:.|...| .::..::..::  |...:::.|...|:..| |
Human   576 GNDSSVPRNKNPFQEAIVFVVGGGNYIEYQNLVDYIKGKQGKHI--LYGCSELFNATQFIKQL-S 637

  Fly   617 SXGRR 621
            ..|::
Human   638 QLGQK 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
car	NP_001259707.1	Sec1	36..606	CDD:279352	131/678 (19%)
SCFD1	NP_057190.2	Sec1	44..629	CDD:307231	131/679 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810