DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment car and acacb

DIOPT Version :9

Sequence 1:	NP_001259707.1	Gene:	car / 32947	FlyBaseID:	FBgn0000257	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	XP_031751932.1	Gene:	acacb / 100192373	XenbaseID:	XB-GENE-960130	Length:	2427	Species:	Xenopus tropicalis

Alignment Length:	545	Identity:	96/545 - (17%)
Similarity:	178/545 - (32%)	Gaps:	173/545 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 EMPNAFRDVSVDGDTSSLYQAAVGLVQ---------LQRLYGRIPKIYGKGEFAHR--------- 202
            :.|:.||.|..:...|.::  .:.|.|         |...||....::|:.....|
Frog   433 DFPSLFRQVQTEAPGSPIF--VMKLAQHARHLEVQILADQYGHAVSLFGRDCSIQRRHQKIIEEA 495

  Fly   203 --------VWEHAKQLG-RDERTLYNGDKGVVDQLILLDRSIDLLSPLATQLTYEGLIDEFYGIR 258
                    |:|:.:|.. |..:.:.....|.|:.|...|.|...|. |..:|..|....|..
Frog   496 PATVATPSVFEYMEQCAVRLAKMVGYVSAGTVEYLYSEDGSFHFLE-LNPRLQVEHPCTEMI--- 556

  Fly   259 QNKLTLPAENFPSDGALPGGGGSGPRVEESQSLLGDTE--KKTILLHS--------GEQLYAELR 313
             ..:.|||........:|     ..|:::.:.|.|:|.  ...|...:        |..:.|.:.
Frog   557 -CDVNLPAAQLQISMGVP-----LYRIKDIRVLYGETPWGDSPICFENPVNAPNPRGHVIAARIT 615

  Fly   314 NKHFNEVTKLLARKAREIHVQMHATSQDKSVQEIKSFVENLLPQLMAQKKATSEHTAIAGLLHEQ 378
            :::.:|..|..:...:|::.        :|.:.:..:..                .|.||.|||
Frog   616 SENPDEGFKPSSGTVQELNF--------RSSKNVWGYFS----------------VAAAGGLHE- 655

  Fly   379 VNAVRFAD-------------------------------DLAAEQEFMVCA---------DIDKP 403
                 |||                               |.....|:::..         :||
Frog   656 -----FADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLIKLLETESFQNNEID-- 713

  Fly   404 SAYIEDLIACRVELNR---VLRLICMQCHAASGFKEKLLNHY-----------KRELVHVYGLEV 454
            :.:::.|||.:|:..:   :|.::|...:.|....:..:|.:           ...|:::..:|:
Frog   714 TGWLDHLIAEKVQAEKPDTMLGVVCGALNVADALFQTCMNEFLHCLERGQVLPAASLLNIVDVEL 778

  Fly   455 LLTISNLEKSGLLHLQTESRAYSVLRKTLHLTVDDNVEIEPKD----ISYVHSFYAPLTARIVEH 515
               ||...|..|...:.....|.::....|:.:|.:   ...|    :||..:.|.......|:.
Frog   779 ---ISERVKYKLKVARQSLTTYVIILNNSHIEIDVH---RLSDGGLLLSYDGNSYTTYMKEEVDR 837

  Fly   516 SLKPLGWQTLKSQINNLP----GPTFEDFQAQLVGIGGRHTVTTVSEGSLLNVPRVVLVCFVGGC 576
            ....:|.:|...:..|.|    .|:           .|:....||.:||.:|         .|.|
Frog   838 YRITIGNKTCVFEKENDPTVLRSPS-----------TGKLLQYTVEDGSHVN---------AGEC 882

  Fly   577 TFAEIAALRF---LAAQEDNNVEFL 598
             ||||..::.   |..||...:.::
Frog   883 -FAEIEVMKMVMALTVQEPGQIHYV 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
car	NP_001259707.1	Sec1	36..606	CDD:279352	96/545 (18%)
acacb	XP_031751932.1	AccC	221..724	CDD:223516	57/334 (17%)
		AccB	775..916	CDD:223585	33/159 (21%)
		Biotin_lipoyl	856..922	CDD:395290	16/72 (22%)
		ACC_central	923..1657	CDD:400565
		Carboxyl_trans	1749..2297	CDD:395825
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002117
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1571
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.900