DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Grip84 and Tubgcp2

DIOPT Version :9

Sequence 1:	NP_728264.1	Gene:	Grip84 / 32946	FlyBaseID:	FBgn0026430	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_001272936.1	Gene:	Tubgcp2 / 74237	MGIID:	1921487	Length:	905	Species:	Mus musculus

Alignment Length:	965	Identity:	294/965 - (30%)
Similarity:	491/965 - (50%)	Gaps:	165/965 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLANLISESQSPLTPESI--------IREFRATSDRRLPACDLIKVLVSISEKRPNFAEVTKEIS 66
            |..:|:.::::|....::        |.||..|.:..|...|.:|     |:...|...:...:|
Mouse    27 VYIDLLQKNRTPYVTTTVSAHSAKVKIAEFSRTPEDFLKKYDELK-----SKNTRNLDPLVYLLS 86

  Fly    67 HILQNKDPMYALLVFVERYSECKPVSESSSSTSLSAMGLPHGNKTSDVNSAAGSVPTTLAIASTS 131
            .:.::|:    .|.|:::.::.:....:|::||               |:.:.|:|...:..||.
Mouse    87 KLTEDKE----TLQFLQQNAKERAELAASAATS---------------NTTSFSIPVAASKMSTQ 132

  Fly   132 TILTTSQNV-SGSTRLSLTQSQDFPTSTPVNCKKATESDTTPVVFVRRGPMDRNRGAGKDERNDL 195
            .:....:.: |.||..:|.||                             ::..|...:|::|
Mouse   133 ELEELRKQLGSVSTGSTLQQS-----------------------------LELTRKMLRDKQN-- 166

  Fly   196 SVIKERVLNAVSDQSLSGYRSVTNKTGNSPKSMPNDLVTLTDVPDEYRTHLLWEYYK-------- 252
                                     ..||.:.:|              ....|.|.:
Mouse   167 -------------------------KKNSGQPLP--------------VFPAWVYERPTLAGDFL 192

  Fly   253 ----VDGDKVPRAEIAAMPLLSQESMLLDELLHCLTGIRESLLVPQKPIISAVGLAKYDTDFDIH 313
                :..|.|  ..|..:||.||||.::::||:.|.|: :...:..:|:     ..:.:..|.:.
Mouse   193 IGSGLSSDTV--LPIGTLPLASQESAVVEDLLYVLVGV-DGRYITAQPL-----AGRQNRTFLVD 249

  Fly   314 THLDRSLTHQVREILPLASYFMGVQKIIAATDGL--GQVMNSLNEALQELTHDFYLIIVQAEQEL 376
            .:||.|:...|..|||:|:.:..|.:.|......  |||.::|..|::.|..::.:::.|.||..
Mouse   250 PNLDLSIRELVNRILPVAASYSTVTRFIEEKSSFEYGQVNHALAAAMRTLVKEYLILVTQLEQLH 314

  Fly   377 RHNRLTLQKLLYYLQPTMWVMHEVWSSLVIIQLSDSRDAEVLTYLHERIKRLEGNKDAQQLIIGL 441
            |...|:||||.:|:||.|..:..:.|....:...:......|:.||:|.....|:..||:|.:.|
Mouse   315 RQGLLSLQKLWFYIQPAMRTIDILASLATSVDKGECVGGSTLSLLHDRSFNYTGDSQAQELCLYL 379

  Fly   442 VRKAAKPYMRMLQMWIQKGVIVDRHREFLVVDNEVIHRDELPEHYSDDYWERRYTLRDEQIPSFL 506
            .:.|:.||..:|:.||.:|:|.|.:.||:|.::| :.::::.|.|:|.||::|||:..:||||||
Mouse   380 TKAASAPYFEILEKWIYRGIIHDPYSEFMVEEHE-LRKEKIQEDYNDKYWDQRYTVLPQQIPSFL 443

  Fly   507 AKYSDKILRTGKYLNVIRQCGKRVMPTQEMNLEFDPTSERHVSVINDAYYFAARMLLDVLLTEND 571
            .|.:.|||.|||||||:|:||..|.......:.:......:|..|..|:.:|:::|||.|:.|.:
Mouse   444 QKVAGKILSTGKYLNVVRECGHDVTCPVAKEIIYTLKERAYVEQIEKAFNYASKVLLDFLMEEKE 508

  Fly   572 LMGHLQSVKRYLLLNQGDFTMQFMDACEDELTKNVDHVLPMTLENLLGLTLRISSARNDPYKDDL 636
            |:.||:|:|||.|::||||.:.|||..|:||.|.|:.::...||.||.|.||:|:|..||:||||
Mouse   509 LVAHLRSIKRYFLMDQGDFFVHFMDLTEEELRKPVEDIILTRLEALLELALRMSTANTDPFKDDL 573

  Fly   637 HCELLPYDLVTQMSKIMKKEENWQ-----AQP-RLDLSGLECFAFTYEVKWPCSLVLNHISISKY 695
            ..||:|:||:||:.:::..|...:     |.| .|.|||||.|:|.|.||||.||::|..::::|
Mouse   574 KIELMPHDLITQLLRVLAIETKQEKAMTHADPTELTLSGLEAFSFDYMVKWPLSLIINRKALTRY 638

  Fly   696 QMLFRQLFYCKHVERQLCKIWKENSIARQFEPQAASLYRAAFTLRQRMMNAIQNLEYYMMIEIIE 760
            |||||.:|||||||||||.:|..|..|:|....:|..:..||||||||:|.:||::||||.|::|
Mouse   639 QMLFRHMFYCKHVERQLCSVWISNKTAKQHALHSAKWFAGAFTLRQRMLNFVQNIQYYMMFEVME 703

  Fly   761 PNWHIFIEKMKTVENVDNVLRLHQDFLDSCLKNCMLTESSHLNRSIFKLCKICLKYCEFIQ-ITQ 824
            |.|||..:.:|:..|:|:||..|..|||:|||:|||| :..|.:...||..:|:.:...:| .||
Mouse   704 PTWHILEKNLKSASNIDDVLGHHTSFLDNCLKDCMLT-NPELLKVFSKLMSVCVMFTNCMQKFTQ 767

  Fly   825 RYFQDAELRSMVRDSAD----SSESEQ---------------ESLHCPQIETPLDPTDTFSERVR 870
            ....|:||..:..|...    .:|:|:               |.:..||:.:..:.|      :.
Mouse   768 SMKLDSELGRLTLDQGSVQGPPTETERIEDRPRKELTRKHLSEHVDAPQLASGFEAT------IN 826

  Fly   871 RFDLEFTQLLISFLKQINSMAKKNTADC---FMNLVHRINFNAFYTDQMDKMCVE 922
            .||..|:..|:..|.:::..   :|:||   ..:::.|::||.||.::::::..|
Mouse   827 NFDKNFSAHLLDLLARLSVY---STSDCEHGMASVISRLDFNGFYAERLERLSAE 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip84	NP_728264.1	Spc97_Spc98	278..795	CDD:282045	212/524 (40%)
Tubgcp2	NP_001272936.1	Spc97_Spc98	220..738	CDD:282045	212/524 (40%)
Tubgcp2	NP_001272936.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	877..905		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834100
Domainoid	1	1.000	278	1.000	Domainoid score	I1703
eggNOG	1	0.900	-	-		E1_KOG2001
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55980
Inparanoid	1	1.050	466	1.000	Inparanoid score	I1526
Isobase	1	0.950	-	0	Normalized mean entropy	S5476
OMA	1	1.010	-	-		QHG56391
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005184
OrthoInspector	1	1.000	-	-		oto93342
orthoMCL	1	0.900	-	-		OOG6_101900
Panther	1	1.100	-	-	LDO	PTHR19302
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R53
SonicParanoid	1	1.000	-	-		X4216
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740