DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Grip84 and Tubgcp6

DIOPT Version :9

Sequence 1:	NP_728264.1	Gene:	Grip84 / 32946	FlyBaseID:	FBgn0026430	Length:	926	Species:	Drosophila melanogaster
Sequence 2:	NP_001156791.1	Gene:	Tubgcp6 / 328580	MGIID:	2146071	Length:	1769	Species:	Mus musculus

Alignment Length:	972	Identity:	175/972 - (18%)
Similarity:	329/972 - (33%)	Gaps:	304/972 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ALRGVLANLISE---------SQSPLTPESIIREFRATSDRRL----PACDLIKVLVSISEKRPN 57
            |...:.|||..|         |:.|:..:.::..|    |.|:    |..|.::.||...|..|:
Mouse    41 AYNALFANLFQEDTHQRQPDSSKLPVKNKVLMLSF----DLRVGGLGPEADRLEELVEKLEAAPD 101

  Fly    58 --FAEVTKEISHILQNKDPMYALLVFVERYSECKPVSESSSSTSLSAMGLPH----------GNK 110
              |.||...:..::|                             |:..|.|.          .||
Mouse   102 CPFVEVASVLDLLVQ-----------------------------LAGSGPPQVLRRKRDYFFNNK 137

  Fly   111 TSDVN---SAAGSVPTTLAIASTSTILTTSQNVSGSTRLSLTQSQD------FPT----STPVNC 162
            .:..|   |.......::......:.::..:|:...|.....|..:      .||    |...:|
Mouse   138 HAGRNIPYSGYDCYDLSVFEMDVRSFISGEENLCHHTVQEALQVMEAAPGTGLPTVGLFSIGDSC 202

  Fly   163 KKATESDTTPVVFVRRGPMDRNRGAGKDERNDLSVIKE---------RVLNAVSDQSLSGYRSVT 218
            ....|.||...:|   |.:..:|....|.|.||..:.:         :|...|......|::|.:
Mouse   203 GDRFERDTRVSLF---GALVHSRTYDMDVRLDLPPVPDSADFSGLAIKVPQIVDQWEDEGFQSAS 264

  Fly   219 NKT--GNSPKSMPNDL----VTLTDVPDEYRTHLLWE------------YYKVDG----DKVPR- 260
            |.|  ..|..||..||    ..||....:.|   .||            |....|    |:..|
Mouse   265 NLTPDSQSEPSMTPDLDLWEAVLTYEASKRR---CWERIGCPPGHREEPYLTEAGRDAFDRFCRL 326

  Fly   261 --AEIAAM---------PLLSQESMLLDELLHCLTGIRE---SLLVPQKPIISAVGLAKYDTDFD 311
              .|:.|:         |:|.:||.|:.:.|:.|.|:..   ||..|.:..:...|:
Mouse   327 RHGELQALSGGLLQAPKPVLVEESELVKDSLNVLLGVVSATFSLCRPTQAFVVEPGV-------- 383

  Fly   312 IHTHLDRSLTHQVREIL-PLASY--------FMGVQKIIAATDGLGQVMNSLNEALQELTHDFYL 367
               |:..:....:..|| .:|.|        ...:|.::.:....|.|..:....|:.....:..
Mouse   384 ---HVSGASPESISSILSEVAEYGTCYTRLSHFSLQPVVGSLCSRGLVFQAFTSGLRRYLQYYRA 445

  Fly   368 IIVQAEQELRHNRLTLQKLLYYLQPTMWVMHEVWSSLVIIQLSDSRD--------AEVLTYLHER 424
            .::.....|  :.||:..|...|...:..:.|: ..:..:.|:.|.:        .::|:||::
Mouse   446 CVLSTPPTL--SLLTIGFLFKKLGRQLRYLAEL-CGVGTVSLATSGEPRAVFPTGVKLLSYLYQ- 506

  Fly   425 IKRLEG-NKDAQQLIIGLVRKAAKPYMRMLQMWIQKGVIVDRHREFLV-VDNEVI-HRDELPEHY 486
             :.|:. :.:...:::.|::.:.:||.|.:..|:..||..|.:.||:: |::|.: .||:.
Mouse   507 -EALDNCSNEHYPVLLSLLKTSCEPYTRFIHDWVYSGVFRDVYGEFMIQVNHEYLSFRDKF---- 566

  Fly   487 SDDYWERRYTLRDEQ----IPSFLAKYSDKILRTGKYLNVIRQCGKRVMPTQEMNLEFDPTSERH 547
               ||...|.|..::    :|.||...:..:...||.:|:::.|..|      ..|.:.......
Mouse   567 ---YWTHGYVLISKEVEDCVPVFLKHIAHDVYVCGKTINLLKLCCPR------HYLCWSDVPVPR 622

  Fly   548 VSVINDAYYFAARMLLDVLLTEND---LMGHLQSVKRYLLLNQGDFTMQFMDACEDELTKNVDHV 609
            :|||     |:...|.::   |.|   .:|.::.|.|:..:::.:..:: |:..:.||..:....
Mouse   623 ISVI-----FSLEELKEI---EKDCAVYVGRMERVARHSCISKEEKELR-MEIAKQELIVHAREA 678

  Fly   610 LPMTLENLLGLTLRISSARNDPYKDDLHCELLPYDLVTQMSKIMKKEENWQAQPRLDLSGLECFA 674
            ....|.                       ||....:..|:::..:|.|
Mouse   679 ASRVLS-----------------------ELSDRQMAEQIAQDTRKRE----------------- 703

  Fly   675 FTYEVKWPCSLVLNHISISKYQMLFRQLFYCKHVERQLCKIWKENSIARQFEPQAASLYRAAFTL 739
                               ::|.|..|  :.|..||:|.        |||.|......|......
Mouse   704 -------------------QFQRLKEQ--FVKDQERRLA--------ARQEELDDDFSYARELRD 739

  Fly   740 RQRMMNAIQNLEYYMMIEIIEPNWHIFIEKMKTVENVDNVLRLHQDFLDSCLKNCMLTESSHLNR 804
            |::.:.|::.                .:|:......||:..:|..:            .:....:
Mouse   740 REKRLKALEE----------------ELERKARQALVDHYSKLSAE------------AARREQK 776

  Fly   805 SIFKLCKICLKYCEFIQITQRY-FQDAELRSMVRDSADSSESEQESLHCPQIETPLDPTDTF 865
            :::::              ||: .:.|.||.::.|    .:..||.|...:.:.|.:|...|
Mouse   777 ALWRI--------------QRHRLESARLRFLLED----QKCIQEMLRDMEAQQPQEPPSVF 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Grip84	NP_728264.1	Spc97_Spc98	278..795	CDD:282045	92/546 (17%)
Tubgcp6	NP_001156791.1	Spc97_Spc98	355..>611	CDD:282045	54/284 (19%)
		NBP1	<622..>752	CDD:285709	33/223 (15%)
		ARGLU	631..759	CDD:291991	30/216 (14%)
		Ehrlichia_rpt	672..1249	CDD:118064	36/264 (14%)
		DUF4200	689..785	CDD:290574	23/183 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	809..842		3/12 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	859..881
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1284..1360
		Spc97_Spc98	<1403..1667	CDD:282045
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910